ACM  >> Vol. 5 No. 2 (June 2015)

    中药过敏反应文献分析与认知情况问卷调查
    The Literature Analysis and Questionnaire Survey of Cognitive Situation about Chinese Medicine Allergic Reaction

  • 全文下载: PDF(377KB) HTML   XML   PP.64-71   DOI: 10.12677/ACM.2015.52012  
  • 下载量: 806  浏览量: 3,087   科研立项经费支持

作者:  

樊 孟,陈玉琼,刘晓波,张菊艳,邹 琴,张 萃:广东药院病原生物学与免疫学系,广东 广州;
李川海:重庆市人口和计划生育科学技术研究院,重庆;
龚节合,黄 斌:重庆市黔江区妇幼保健院,重庆;
王世芳:重庆市黔江区卫生局,重庆

关键词:
中药注射剂超敏反应类过敏问卷调查Traditional Chinese Medicine Injection Hypersensitivity Anaphylactoid Questionnaire Survey

摘要:

目的:增强人们对中药知识及使用的认知程度,合理使用,减少中药的不良反应。方法:首先通过检索中国知网数据库中常用中药注射剂中引起过敏反应报告较多的病例,对患者一般情况及过敏反应类型等进行统计并整理结果;其次对广州市在住居民进行中药过敏反应认知情况问卷调查,并对有效问卷相关内容进行统计分析。结果:在检索到的中药注射剂所致过敏病例1352例中,I型超敏反应占94.75%;男性和成人分别占54.22%和74.56%。在问卷调查中共回收有效问卷268份,对使用中药初次过敏的认识仅为10.77%,55.38%的人数为不清楚;对中药使用较多的女性占64.62%;使用中药原因认为有效及副作用少的分别占42.93%、51.52%。结论:临床药物过敏类型中不可忽视I型或与I型类似的类过敏反应的反生;提高人们对中药的认知程度,中药是国宝,但要注意选择适合的剂型,正确、合理使用,保证用药的安全性。

Objective: To enhance people’s cognition for traditional Chinese medicine knowledge and use, reasonable use, reduce the adverse reaction of traditional Chinese medicine. Methods: First, re-trieve traditional Chinese medicine injections which are commonly used and caused lots of allergic reactions cases in the report by the China National Knowledge Infrastructure, statistic data about the patient’s general situation and allergic reaction type and so on, and sort result; second, investigate Guangzhou residents perceptions of Chinese medicine allergic reaction, and make a careful analysis of related contents in the valid questionnaires. Results: Retrieve 1352 allergic cases were caused by traditional Chinese medicine injection, the effective rates of type I immune hypersensitivity reactions, males and adults were 94.75%, 54.22% and 74.56% respectively. In 268 effective questionnaires, the effective rates were 10.77% for the first time allergy which was caused by using traditional Chinese medicine, 55.38% residents were not clear; women which often used traditional Chinese medicine made up 64.62%; it accounted for 42.93%, 51.52% respectively because traditional Chinese medicine were effective and less side effects to use it. Conclusion: In the allergy type of clinical drug, type I allergic reaction or anaphylactoid can not be neglected. Improve people’s cognition of the traditional Chinese medicine, traditional Chinese medicine is a national treasure, but it should pay attention to choose the suitable dosage forms, correct and reasonable use, guarantee the safety of medication.

文章引用:
樊孟, 陈玉琼, 刘晓波, 张菊艳, 邹琴, 张萃, 李川海, 龚节合, 黄斌, 王世芳. 中药过敏反应文献分析与认知情况问卷调查[J]. 临床医学进展, 2015, 5(2): 64-71. http://dx.doi.org/10.12677/ACM.2015.52012

参考文献

[1] 黄秀纯, 吴雪荣 (2013) 中成药不良反应的文献与问卷调查分析及预防对策. 中国药业, 22, 78-80.
[2] 李黎明, 金若敏, 李小月 (2012) 中药注射剂类过敏反应实验研究进展. 中药药理与临床, 28, 187-190.
[3] 谢毓晋 (1980) 类过敏反应. 武汉医学杂志, 4, 155-160.
[4] 陈秀强 (2001) 临床输液反应的因素. 中国医院药学杂志, 21, 33-35.
[5] 李佳, 黄芝瑛 (2010) 注射用辅料类过敏反应的非临床评价方法. 药物评价研究, 33, 9-12.
[6] 康健 (2013) 59例复方丹参注射液致过敏反应的文献分析. 中国药物警戒, 10, 744-748.
[7] 冯艳霜 (2002) 187例中药致过敏反应文献分析. 药物不良反应杂志, 4, 81-83.
[8] 韩尧 (2013) 滥用中药危害不容忽视. 首都医药, 5, 10-11.
[9] Johannes, R. and Heidrun, B. (1997) Anaphylaxis and anaphylactoid reactions. Clinical Reviews in Al-lergy and Immunology, 17, 387-399.