热疗联合放化疗治疗乳腺癌皮肤复发病例2例临床病理观察

Clinical Observation of 2 Cases of Recurrent Breast Cancer Treated by Hyperthermia Combined with Radiotherapy and Chemotherapy

摘要: 背景：热疗目前广泛应用于辅助传统的放化疗手段治疗某些恶性肿瘤，尤其是对一些单纯依靠放化疗不敏感的肿瘤患者。辅助的热疗常可提高肿瘤病人对传统放化疗的敏感性。病例报告：我们报告两例乳腺癌根治术后复发患者，于腋窝部位皮下浅表软组织内发现转移灶，单纯应用放化疗治疗复发转移病灶效果不明显。随后，我们联合应用放化疗辅助热疗手段，转移瘤灶显著缩小，病理学活检提示肿瘤细胞坏死明显。患者生活质量得到改善。结论：热疗可以有效地提高某些肿瘤患者传统放化疗的敏感性，为某些对放化疗不敏感的肿瘤患者提供新的治疗途径。

Abstract: Background: Hyperthermia is widely used in the treatment of some malignant tumors, especially for the tumor patients who are not sensitive to radiotherapy and chemotherapy. The sensitivity of tumor patients to conventional radiotherapy and chemotherapy can be improved by the aid of hyperthermia. Case Report: We reported two cases of recurrent breast cancer after radical mas-tectomy, found in the subcutaneous superficial soft tissue in the axillary region, and the effect of chemotherapy on the recurrence and metastasis was not obvious. Subsequently, we combined with the application of radiotherapy and chemotherapy; the tumor cells were significantly reduced, and the pathological biopsy showed obvious necrosis of tumor cells. Patients’ quality of life has been improved. Conclusion: Hyperthermia can effectively improve the sensitivity of conventional radiotherapy and chemotherapy in some tumors, and provide new therapeutic approach for the treatment of cancer patients with no sensitiveness.