基本情况

罗元明,博士,研究员级高级工程师,中国科学院微生物研究所公共技术服务中心副主任,微生物资源前期开发国家重点实验室蛋白质组学研究平台负责人;2014年中国科学院“现有关键技术人才计划”获得者;中国科学院评审专家(工程技术类)。

 

研究领域

糖蛋白质组学、修饰组学及生物医药产业化工艺研发。主持及参与了12项省部级及以上课题。依托蛋白质组学研究平台,开发了多项生物医药及生物材料等领域的产业化工艺及质量控制技术体系,如疫苗研制、工业酶筛选、抗肿瘤药物研制等。

 

教育背景

2001年至2004年 博士,中国协和医科大学

1998年至2001年 硕士,吉林大学

1992年至1996年 学士,重庆师范大学

 

论文发表

  1. Wang J, Zhou H, Lu H, Du T, Luo Y, Wilson IB, Jin C. Kexin-like endoprotease KexB is required for N-glycan processing, morphogenesis and virulence in Aspergillus fumigatus. Fungal Genet Biol. 2015, 76: 57-69
  2. Lu H, Lü Y, Ren J, Wang Z, Wang Q, Luo Y, Han J, Xiang H, Du Y, Jin C. Identification of the S-layer glycoproteins and their covalently linked glycans in the halophilic archaeon Haloarcula hispanica. Glycobiology. 2015
  3. Liu L. J., Stockdreher Y, Koch T, Sun S. T., Fan Z, Josten M, Sahl H. G., Wang Q., Luo Y. M., Liu S. J., Dahl C, Jiang C. Y. Thiosulfate transfer mediated by DsrE/TusA homologs from acidothermophilic sulfur-oxidizing archaeon Metallosphaera cuprina. J Biol Chem, 2014, 289(39): 26949-26959
  4. Chen Z, Feng D, Zhang B, Wang Q, Luo Y, Dong X. Proteomic insights into the temperature responses of a cold-adaptive archaeon Methanolobus psychrophilus R15. Extremophiles, 2015, 19: 249-259
  5. Wang S, Chen S, Wang J, Xu P, Luo Y, Nie Z, Du W. Interface Solution Isoelectric Focusing with in situ MALDI-TOF Mass Spectrometry. Electrophoresis, 2014, 35(17): 2528-2533
  6. Liu H, Luo Y, Han J, Wu J, Wu Z, Feng D, Cai S, Li M, Liu J, Zhou J, Xiang H. Proteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations. J Proteome Res, 2013, 12(3): 1300-1315
  7. Sun L, Chen L, Sun L, Pan J, Yu L, Han L, Yang Z, Luo Y, Ran Y. Functional screen for secreted proteins by monoclonal antibody library and identification of Mac-2 binding protein as a potential therapeutic target and biomarker for lung cancer. Mol Cell Proteomics, 2013, 12(2): 395-406
  8. Guo X, Jiang C, Luo Y, Zhang Y, Poetschd A, Liu S. Proteomic and molecular investigations revealed that Acidithiobacillus caldus adopts multiple strategies for adaptation to NaCl stress. Chin Sci Bull, 2014, 59(3): 301-309
  9. Chu Y, Zhang Z, Wang Q, Luo Y, Huang L. Identification and characterization of a highly conserved crenarchaeal protein lysine methyltransferase with broad substrate specificity. J Bacteriol, 2012, 194(24): 6917-6926
  10. Yu T, Xu X, Peng Y, Luo Y, Yang K. Cell wall proteome of Clostridium thermocellum and detection of glycoproteins. Microbiol Res,2012, 167: 364-371
  11. Fan K, Zhang X, Liu H, Han H, Luo Y, Wang Q, Geng M, Yang K. Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells. J Antibiot, 2012, 65(9): 449-452
  12. Sun Q, Liu X, Wang Q, Luo Y, Wang X. Protein expression pattern identifies morphological variability of ascomatal hairs in the two species of genus Chaetomium. Acta Microbiologica Sinica, 2012, 52(10): 1203-1209
  13. Wang F. X., Ma Y. Y., Yang C. L., Zhao P. M., Yao Y, Jian G. L., Luo Y. M., Xia G. X. Proteomic analysis of the sea-island cotton roots infected by wilt pathogen verticillium dahlia. Proteomics, 2011, 11, 4296-4309
  14. Yu T, Luo Y, Yang K. Rapid characterization of N-linked glycosylation site using non-specific protease digestion of gel-separated glycoproteins and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry. Eur J Mass Spectrom, 2011, 17(6): 573-579
  15. Yin H, Xiang S, Zheng J, Fan K, Yu T, Yang X, Peng Y, Wang H, Feng D, Luo Y, Bai H, Yang K. argR mutation induced holomycin production and complex metabolic changes in Streptomyces clavuligerus NP1. Appl Environ Microbiol, 2012, 78(9): 3431-3441
  16. Peng Y, Luo Y, Yu T, Xu X, Fan K, Zhao Y, Yang K. A Blue Native-PAGE analysis of protein complexes in Clostridium thermocellum. BMC Microbiol, 2011, 11(1): 22
  17. Li J, Cai S, Luo Y, Dong X. Three feruloyl esterases in Cellulosilyticum ruminocola H1 act synergistically to hydrolyze esterified polysaccharides. Appl Environ Microbiol, 2011, 77: 6141-6147
  18. Wang X, Zhao Z, Luo Y, Chen G, Li Z. Gel-based proteomics analysis of the heterogeneity of 20S proteasomes from four human pancreatic cancer cell lines. Proteomics Clin Appl, 2011, 5: 484-492
  19. Mao S, Luo Y, Bao G, Zhang Y, Li Y. Ma Y. Comparative analysis on the membrane proteome of Clostridium acetobutylicum wild type strain and its butanol-tolerant mutant. Mol Biosyst, 2011, 7: 1660-1677
  20. Wu W, Dai H, Bao L, Ren B, Lu J, Luo Y, Guo L, Zhang L, Liu H. Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp. J Nat Prod. 2011,74:1303-1308
  21. Zhao P. M., Wang L. L., Han L. B., Wang J, Yao Y, Wang H. Y., Du X. M., Luo Y. M., Xia G. X. Proteomic identification of differentially expressed proteins in the Ligon lintless mutant of upland cotton(Gossypium hirsutum L.). J Proteome Res, 2010, 9(2): 1076-1087
  22. Mao S, Luo Y, Zhang T, Li J, Zhang Y, Ma Y, Li Y. Proteome reference map and comparative proteome analysis between a wild type Clostridium acetobutylicum DSM 1731 and its mutant with enhanced butanol tolerance and butanol yield. J Proteome Res, 2010, 9(6): 3046-3061
  23. Ouyang H, Luo Y, Zhang L, Li Y, Jin C. Proteome analysis of Aspergillus fumigatus total membrane proteins identifies proteins associated with the glycoconjugates and cell wall biosynthesis using 2D LC-MS/MS. Mol Biotechnol, 2010, 44(3): 177-189