基本情况

刘接卿，副教授，华侨大学生物医学学院药学系主任，理学博士，硕士研究生导师。


研究领域

天然资源尤其是中草药中新颖活性成分的提取分离和结构鉴定、从天然产物中寻找药物先导和候选结构、具有重要生物活性天然产物的结构修饰和作用机制研究、天然产物活性分子的分子探针合成及作用靶标研究。

 

教育背景

2006年9月至2009年7月，首都师范大学生命科学院，遗传学博士；

2003年9月至2006年7月，吉林大学药学院，药物化学硕士；

1999年9月至2003年7月，吉林大学药学院，药学学士。

 

工作经历

2015年1月至今，华侨大学生物医学学院，副教授；

2013年1月至2014年12月，中国科学院昆明植物研究所，副研究员；

2012年1月-2012年12月，中国科学院昆明植物研究所，助理研究员；

2009年8月至2011年12月，中国科学院昆明植物研究所，博士后，合作导师邱明华研究员。

 

科研项目

在科研方面一直致力于中草药活性物质基础和相关活性作用机理研究，到目前为止已分离鉴定和活性筛选了500余个化合物，取得了多项天然药物研究成果：从小桐子中筛选出了具有抗肿瘤活性的候选化合物；从闽产灵芝中发现抗过敏活性的芳香杂萜类分子；从“维生素C之王”针叶樱桃中发现具有抑制AChE活性的新颖结构等。基本阐明抑制前列腺癌增殖和转移的候选药物CurA的分子作用机制和靶标确证工作，正进行临床前药学其他方面的研究工作；已发现对乳腺癌具有良好抑制作用的天然先导化合物分子JQ222，正进行构效关系和作用机制研究。已在天然产物化学和食品化学领域如Organic Letters, Phytochemistry, Planta Medica, Tetrahedron, Journal of Agricultural and Food Chemistry, Food Chemistry等国际杂志上发表和参与发表SCI论文30余篇。

 

荣誉奖励
2014年01月入选第十六批云南省中青年学术和技术带头人后备人才；

2014年11月入选龙岩市首批创新人才。

 

论文发表

  1. Liu, J.-Q.; Yang, Y.-F.; J.-J; Li, X.-Y; Li,Z.-R; Zhou, L.; Qiu, M.-H*. Cytotoxic diterpenoids from Jatropha curcas cv. Nigroviensrugosus CY Yang roots. Phytochemistry, 117, 462‒468, 2015
  2. Liu, J.-Q.; Deng, Y.-Y.; Li, Y.; Li, T.-Z.; Han, Q.; Qiu, M.-H.*, Three New Tetranorditerpenes from Aerial Parts of Acerola Cherry (Malpighia emarginata). Molecules, 19 (2), 2629-36, 2014
  3. Li X.-Y, Yang Y.-F, Peng X.-R, Li M.-M, Li L.-Q, Deng X, Qin H.-B*, Liu J.-Q*, Qiu M.-H*. One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B. Organic Letters, 12(8),2196-2199, 2014
  4. Liu, J.-Q.; Yang, Y.-F.; Li, X.-Y.; Liu, E.-Q.; Li, Z.-R.; Zhou, L.; Li, Y.; Qiu, M.-H.*,Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas.Phytochemistry (Elsevier), 96, 265-272, 2013
  5. Liu, J.-Q.; Peng, X.-R.; Zhang, W.-M.; Shi, L.; Li, X.-Y.; Chen, J.-C.; Qiu, M.-H.*,Swietemahalactone, a rearranged phragmalin-type limonoid with anti-bacterial effect, fromSwietenia mahagoni. RSC Advances, 3, (15), 4890-4893, 2013
  6. Liu, J.-Q.; Peng, X.-R.; Li, X.-Y.; Li, T.-Z.; Zhang, W.-M.; Shi, L.; Han, J.; Qiu,M.-H.*,Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree(Malpighia emarginata). Organic Letters, 15, (7), 1580-1583, 2013
  7. Liu, J.-Q.; Yang, Y.-F.; Wang, C.-F.; Li, Y.; Qiu, M.-H.*, Three new diterpenes fromJatropha curcas. Tetrahedron, 68, (4), 972-976, 2012
  8. Liu, J.-Q.; Wang, C.-F.; Li, Y.; Luo, H.-R.; Qiu, M.-H.*, Isolation and bioactivityevaluation of terpenoids from the medicinal fungus Ganoderma sinense. Planta Medica,78, (4), 368-376, 2012
  9. Liu, J.-Q.; Wang, C.-F.; Li, Y.; Chen, J.-C.; Zhou, L.; Qiu, M.-H.*, Limonoids fromthe leaves of Toona ciliata var. yunnanensis. Phytochemistry (Elsevier), 76, 141-149, 2012
  10. Liu, J.-Q.; Wang, C.-F.; Chen, J.-C.; Qiu, M.-H.*, Limonoids from the leaves ofSwieteniamacrophylla. Natural Product Research, 26, (20), 1887-1891, 2012
  11. Liu, J.-Q.; Wang, C.-F.; Peng, X.-R.; Qiu, M.-H.*, New alkaloids from the fruitingbodies of Ganoderma sinense. Natural Products and Bioprospecting, 1, (2), 93-96, 2011
  12. Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Chen, J.-C.; Li, Y.; Qiu, M.-H.*, One newpregnane glycoside from the seeds of cultivated Brucea javanica. Archives of PharmacalResearch, 34, (8), 1297-1300, 2011
  13. Liu, J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H.*, One new cucurbitane triterpenoid from the fruits of Momordica charantia. European Journal of Chemistry, 1, (4), 294-296, 2010
  14. Liu, J.-Q.; Wang, C.-F.; Chen, J.-C.; Tu, S.-H.; Gu, H.-F.; Hu, W.-X.; Qiu, M.-H.*, Six New Triterpenoid Glycosides from Gynostemma pentaphyllum. Helvetica Chimica Acta 92, (12), 2737-2745, 2009
  15. Liu, J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H., New cucurbitane triterpenoids and steroidal glycoside from Momordica charantia. Molecules 14, (12), 4804-4813, 2009
  16. Peng, X.-R.; Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Shu, Y.; Zhou, L.; Qiu, M.-H.*, Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear. Journal of Natural Products,77(4), 737-743, 2014
  17. Peng, X.-R.; Liu, J.-Q.; Xia, J.-J.; Wang, C.-F.; Li, X.-Y.; Deng, Y.; Bao, N.-M.; Zhang, Z.-R.; Qiu, M.-H.*, Lanostane triterpenoids from Ganoderma hainanense J. D. Zhao. Phytochemistry,114, 137-245, 2014
  18. Peng, X..-R.; Liu, J.-Q.; Wang, C.-F.; Han, Z.-H.; Shu, Y.; Li, X.-Y.; Zhou, L.; Qiu, M.-H.*, Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear. Food chemistry, 171, 251-257, 2015
  19. Zhao, G.-T.; Liu, J.-Q.; Deng, Y.-Y.; Li, H.-Z.; Chen, J.-C.; Zhang, Z.-R.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-Type Triterpenoids from the Stems and Leaves of Momordica charantia. Fitoterapia, 96, 79-82, 2014
  20. Shu, Y.; Liu, J.-Q.; Peng, X.-R.; Wan, L.-S.; Zhou, L.; Zhang, T.; Qiu, M.-H.*, Characterization of diterpenoid glucosides in roasted Puer coffee bean. Journal of Agricultural and Food Chemistry, 62 (12), 2631–2637, 2014
  21. Hu, K.; Liu, J.-Q.; Li, X.-N.; Chen, J.-C.; Zhang, W.-M.; Li, Y.; Li, L.-Q.; Guo,L.-L.; Ma, W.-G.; Qiu, M.-H.*, Chukfuransins A-D, Four new phragmalin limonoids with-furan ring involved in skeleton reconstruction from Chukrasia tabularis. OrganicLetters, 15, (15), 3902-3905, 2013
  22. Peng, X.-R.; Liu, J.-Q.; Han, Z.-H.; Yuan, X.-X.; Luo, H.-R.; Qiu, M.-H.*,Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity inHepG2 cells. Food Chemistry, 141, (2), 920-926, 2013
  23. Wang, H.-W.; Liu, J.-Q.; Chen, J.-X.; Yang, Y.-F.; Yan, Y.-X.; Li, Z.-R.; Qiu,M.-H.*, New triterpenoids from the kernels of Azadirachta indica. Natural Products andBioprospecting, 3, (1), 33-37, 2013
  24. Yang, Y. F.; Liu, J. Q.; Li, X. Y.; Liu, E. Q.; Li, Z. R.; Qiu, M. H.*, New terpenoidsfrom the roots of Jatropha curcas. Chinese Science Bulletin, 58, (10), 1115-1119, 2013
  25. Yang, Y.-F.; Liu, J.-Q.; Li, Z.-R.; Li, Y.; Qiu, M.-H.*, New eudesmenoic acidmethyl esters from the seed oil of Jatropha curcas. Fitoterapia, 89, 278-284, 2013
  26. Yang, Y.-F.; Liu, J.-Q.; Shi, L.; Li, Z.-R.; Qiu, M.-H.*, New jatropholane-typediterpenes fromJatropha curcas cv. Multiflorum CY Yang. Natural Products andBioprospecting, 3, (3), 99-102, 2013
  27. Peng, X. R.; Liu, J. Q.; Wan, L. S.; Li, X. N.; Yan, Y. X.; Qiu, M. H.*, Four new polycyclic meroterpenoids from Ganoderma cochlear. Organic letters, 16, (20), 5262-5265, 2014
  28. Yan, Yu-Xin; Liu, Jie-Qing; Wang, Hong-Wei; Chen, Jin-Xiong; Chen, Jian-Chao; Chen, Li; Zhou, Lin; Qiu, Ming-Hua; Identification and Antifeedant Activities of Limonoids from Azadirachta indica; Chemistry & Biodiversity (2015), 12(7), 1040-1046
  29. Peng, XingRong; Liu, JieQing; Wang, CuiFang; Han, ZhongHui; Shu, Yi; Li, XuYang; Zhou, Lin; Qiu, MingHua; Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear; Food Chemistry (2015), 171, 251-257
  30. Yan, Yu-Xin; Liu, Jie-Qing; Chen, Jin-Xiong; Chen, Jian-Chao; Qiu, Ming-Hua; Three new limonoids from Azadirachta indica; Journal of Asian Natural Products Research (2015), 17(1), 14-19
  31. Chen Jian-Chao; Liu Jie-Qing; Zhou Lin; Qiu Ming-Hua; Lau Clara Bik-San; Chan Judy Yuet-Wa; Fung Kwok-Pui; Leung Ping-Chung; Xie Ming-Jin; The antigluconeogenic activity of cucurbitacins from Momordica charantia; Planta medica (2015), 81(4), 327-332
  32. Jiang, S.-Y.; Liu, J.-Q.; Xia, J.-J.; Yan, Y.-X.; Qiu, M.-H.*, Five newtetranortriterpenoids from the seeds of Toona ciliata. Helvetica Chimica Acta, 95, (2),301-307, 2012
  33. Peng, X.-R.; Liu, J.-Q.; Xia, J.-J.; Yang, Y.-H.; Qiu, M.-H.*, Two new triterpenoidsfrom Ganoderma cochlear. Zhongcaoyao, 43, (6), 1045-1049, 2012
  34. Wang, C.-F.; Liu, J.-Q.; Yan, Y.-X.; Chen, J.-C.; Lu, Y.; Guo, Y.-H.; Qiu, M.-H.*, Three new triterpenoids containing four-membered ring from the fruiting body of Ganoderma sinense. Organic Letters, 12, (8), 1656-1659, 2010
  35. Cheng, B.-H.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-type triterpenoids from Momordica charantia. Helvetica Chimica Acta, 96, (6), 1111-1120, 2013
  36. Xu, W.-X.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Wang, Y.-F.; Qiu, M.-H.*, Three newphysalins from Physalis alkekengi var. franchetii. Natural Products and Bioprospecting,3, (3), 103-106, 2013