盐酸文拉法辛的合成
Synthesis of Venlafaxine Hydrochloride
DOI: 10.12677/SSC.2013.11001, PDF, HTML,    科研立项经费支持
作者: 朱园园*, 古双喜*：武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室；李婷婷*：中国科学院武汉水生生物研究所
关键词: 盐酸文拉法辛；合成；抗抑郁药；茴香醇；Venlafaxine Hydrochloride; Synthesis; Antidepressant; Anisic Alcohol
摘要: 以廉价易得的茴香醇为原料，经7步反应以56.7%的总收率合成得到盐酸文拉法辛。该路线简捷高效，反应条件温和，后处理操作简单，适合工业化生产。  Venlafaxine hydrochloride was synthesized via 7-step reactions in the total yield of 56.7% from anisic alcohol. The synthetic route is concise and efficient, and suitable for industrialization due to its mild reaction conditions and simple post-treatment.

 

文章引用：朱园园, 李婷婷, 古双喜. 盐酸文拉法辛的合成[J]. 合成化学研究, 2013, 1(1): 1-3. http://dx.doi.org/10.12677/SSC.2013.11001

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