摘要:
全世界约有3.5亿人感染乙型肝炎病毒(Hepatitis B virus, HBV)，其中中国有约1.2亿人。应用HBV生物标志物检测，对于HBV的诊断、防治至关重要。目前我国针对HBV的检测方法非常多，这些检测方法基于不同的HBV生物标志物和不同的检测原理，其在临床上的应用以及检测效果也有所不同，因此了解HBV生物标志物及其检测方法的最新进展就显得更为重要。本文逐一介绍了HBV的理化特征、结构、生物标志物以及检测方法的研究进展，以供HBV的临床检测参考。
Hepatitis B is one of the most common infectious diseases around the world. About 350 million people are infected with hepatitis B virus totally in the world, and 120 million people are infected in China. It is very important to apply biomarker detection for diagnosis, prevention and treatment of HBV. At present, there are many detection methods of HBV based on different biomarkers and principles, and they have different clinic application and detection effects, so the progress of the HBV biomarkers and detection methods is more and more important. This article introduced the physical and chemical characteristics, structure, biomarkers of HBV and the research progress of analytical methods, in order to provide the reference for the clinical detection of HBV.