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化学与材料
有机化学研究
Vol. 2 No. 2 (June 2014)
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新型手性N, N, N', N'', N''', N'''-六-[2-(1-羟丁基)]三乙四胺六乙酰胺的合成及其在不对称氢硅化反应中的应用
Synthesis of Novel Chiral Triethylenetetramine-N, N, N', N'', N''', N'''-hexa-[2-(1-hydroxybutanyl)]acetoamide and Their Application in Asymmetric Hydrosilylation
DOI:
10.12677/JOCR.2014.22002
,
PDF
,
HTML
,
,
被引量
下载: 2,937
浏览: 9,143
作者:
李伟杰
:韩山师范学院化学系,潮州
关键词:
三乙四胺六乙酸
;
N
;
N
;
N'
;
N''
;
N'''
;
N'''-六-[2-(1-羟丁基)]三乙四胺六乙酰胺
;
合成
;
不对称氢硅化
;
Triethylenetetramine-N
;
N
;
N'
;
N''
;
N'''
;
N'''-hexaacetic Acid
;
Triethylenetetramine-N
;
N
;
N'
;
N''
;
N'''
;
N'''-hexa-[2-(1-hydroxybutanyl)]acetoamide
;
Synthesis
;
Asymmetric Hydrosilylation
摘要:
在N
2
保护下,三乙四胺六乙酸分别与(R)- 或(S)-2-氨基-1-丁醇在145℃下反应16 h,合成了新的手性化合物(R)-(+)-或(S)-(-)-N, N, N', N'', N''', N'''-六-[2-(1-羟丁基)]三乙四胺六乙酰胺,产率分别为69.5%和71.3%。运用上述手性化合物与[Rh(COD)Cl]
2
作手性催化剂,探讨了其在苯乙酮的不对称氢硅化反应中的催化活性,结果显示其具有较明显的催化活性,但反应的对映选择性较低(仅为37%ee)。
Abstract:
Triethylenetetramine-N, N, N', N'', N''', N'''-hexaacetic acid reacted with (R)- or (S)-2-amino-1-butanol for 16 h at 145˚C under the protection of nitrogen atmosphere, and gave novel chiral compounds (R)-(+)- or (S)-(-)-triethylenetetramine-N, N, N', N'', N''', N'''-hexa-[2-(1-hydroxybutanyl)] acetoamide in the yields of 69.5% and 71.3%, respectively. With the above chiral compounds and [Rh(COD)Cl]
2
as chiral catalysts, the asymmetric hydrosilylation of acetophenone was investigated. The experimental results showed that they had remarkable catalytic activities, but the enantioselectivities of the reaction were low (only 37%ee).
文章引用:
李伟杰. 新型手性N, N, N', N'', N''', N'''-六-[2-(1-羟丁基)]三乙四胺六乙酰胺的合成及其在 不对称氢硅化反应中的应用[J]. 有机化学研究, 2014, 2(2): 13-17.
http://dx.doi.org/10.12677/JOCR.2014.22002
参考文献
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]
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]
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