摘要:
结肠肉瘤样癌(sarcomatoid carcinoma，SC)是一种具有上皮及肉瘤样成分的双相分化的极少见恶性肿瘤，往往生长迅速，易出现复发转移和药物抵抗，预后差，中位生存期一般不超过6个月。确诊需要病理检查和免疫组化，并与癌肉瘤、肉瘤样间皮瘤、间质瘤等鉴别。本文报道一例发生于升结肠的肉瘤样癌带瘤生存已达44个月，出现腹腔和肝脏转移，先后接受两次手术和多程化疗。目前报道的肉瘤样癌仅有2例生存时间超过本病例，因此本例的诊断、临床特点和治疗值得深入探讨。
Abstract:
Sarcomatoid carcinoma of colon is an extremely rare biphasic tumor characterized by a combination of malignant epithelial and sarcomatoid cells. The known characteristics are rapid growth, high rate of recurrence and metastasis, drugs resistance and poor prognosis with median survival less than 6 months. Precise diagnosis warranted histological examination, immunohistochemistry study and exclusion of other diseases, such as carcinosarcoma, sarcomatous mesothelioma and stromal tumor. Herein we report a case of patient who had a sarcomatoid carcinoma of ascending colon and still been alive for 44 months with liver and peritoneal metastasis after two subsequent operations and multiple cycles of chemotherapy. By far, only two patients with colon sarcomatoid carcinoma were reported to survive longer than this case, which deserved to be researched in details on diagnosis, clinical characteristics, therapy and outcome.