CD4⁺CD25⁺调节性T细胞与自身免疫性疾病研究进展

Current Research in CD4⁺CD25⁺ Regulatory T Cells and Autoimmune Diseases

摘要: CD4⁺CD25⁺调节性T细胞是一类参与体内免疫反应和自身免疫反应的细胞亚群，具有免疫调节或免疫抑制功能。越来越多的实验研究表明，CD4⁺CD25⁺调节性T细胞具有维持外周免疫耐受的重要作用，这种T细胞的数量减少或功能缺失与自身免疫性疾病的发生具有相关性。它可以通过细胞接触依赖机制和抑制性细胞因子依赖机制主动抑制自身免疫中的T细胞活化，维持自身免疫耐受，防止自身免疫病的发生。

Abstract: CD4⁺CD25⁺ Regulatory T cells are involved in immune response and immune response in the body’s cells, and have the function of immune adjustment or immunosuppression. Accumulated experiments have proved that CD4⁺CD25⁺ regulatory T cells play an important role in the main-tenance of peripheral immune tolerance, and the decrease or the afunction of them has a correla-tion with the occurrence of autoimmune disease. It can actively suppress the activation of T cells in autoimmunity by cell contact dependent mechanism and inhibitory cytokines, maintain the immune tolerance, and prevent the occurrence of autoimmune disease.