积雪草酸及其衍生物抗肿瘤活性的研究进展
Advances in Studies on Antitumor Activities of Asiatic Acid and Its Derivatives
DOI: 10.12677/HJMCe.2016.42002, PDF, HTML, XML, 下载: 2,005  浏览: 5,243  国家自然科学基金支持
作者: 孟艳秋, 宁梓廷, 杨 丽娜*, 于婷婷, 张伟晨, 潘洪双:沈阳化工大学制药工程教研室,辽宁 沈阳
关键词: 积雪草酸衍生物抗肿瘤Asiatic acid Derivatives Antitumor
摘要: 积雪草酸是一种乌苏烷型五环三萜酸,主要来源于伞形科植物积雪草,具有广泛的药理活性,其抗肿瘤活性尤为显著。本文对积雪草酸及其衍生物的抗肿瘤活性的研究进展进行综述并进行展望。
Abstract: Asiatic acid is a type of pentacyclic triterpene acid from Centella asiatica. It has been found that Asiatic acid has many kinds of pharmacological effects, especially its antitumor activity. In this paper, the research progress of antitumor activity of asiatic acid and its derivatives has been re-viewed and forecasted.
文章引用:孟艳秋, 宁梓廷, 杨丽娜, 于婷婷, 张伟晨, 潘洪双. 积雪草酸及其衍生物抗肿瘤活性的研究进展[J]. 药物化学, 2016, 4(2): 11-17. http://dx.doi.org/10.12677/HJMCe.2016.42002

参考文献

[1] 孟艳秋, 王楠, 张良锋. 积雪草酸生物活性的研究进展[J]. 化学通报, 2013, 76(8): 721-724.
[2] 林丽敏, 赵云, 彭璐, 等. 积雪草酸对高脂血症金黄地鼠的血脂调节及肝脏保护作用研究[J]. 中国生化药物杂志, 2014, 34(4): 12.
[3] 孟艳秋, 张良锋, 张译, 等. 积雪草酸衍生物的合成及抗肿瘤活性研究[J]. 化学通报, 2015, 78(4): 358-363.
[4] 崔福贵. 积雪草酸衍生物在制备防治心、血管疾病的药物中的用途[P]. 中国专利, CN1582946A. 2005-02-23.
[5] Maya, K.H., MinHee, K.K., David, A., et al. (2009) Immune-Based Therapy for Alzheimer’s Disease Is Associated with Elevated Levels of IL-10 in the Brain. Alzheimers and Dementia, 5, 328. http://dx.doi.org/10.1016/j.jalz.2009.04.545
[6] 熊御云, 丁银慧, 李芸子, 等. 积雪草酸抗帕金森样神经损伤的线粒体机制[C]. 全国老年性痴呆与相关疾病学术会议, 2013.
[7] 刘华清, 许青云, 王天麟. 积雪草酸的研究进展[J]. 中国野生植物资源, 2014, 33(4): 30-33.
[8] Cho, C.W., Choi, D.S., Cardone, M.H., et al. (2006) Glioblastoma Cell Death Induced by Asiatic Acid. Cell Biology and Toxicology, 22, 393-408. http://dx.doi.org/10.1007/s10565-006-0104-2
[9] 冯旭, 郭飞飞, 赵龙, 等. 积雪草酸药理作用及其结构修饰的研究进展[J]. 中草药, 2014, 45(7): 1037-1042.
[10] Li, Y., Yang, F., Yuan, M.X., Jiang, L.J., Yuan, L., Zhang, X.W., et al. (2015) Synthesis and Evaluation of Asiatic Acid Derivatives as Anti-Fibrotic Agents: Structure/Activity Studies. Steroids, 96, 44-49. http://dx.doi.org/10.1016/j.steroids.2014.11.001
[11] Tang, X.L., Yang, X.Y., Jung, H.J., et al. (2009) Asiatic Acid Induces Colon Cancer Cell Growth Inhibition and Apoptosis through Mitochondrial Death Cascade. Biological & Pharmaceutical Bulletin, 32, 1399-1405. http://dx.doi.org/10.1248/bpb.32.1399
[12] 周军, 高静, 方春钱. 积雪草酸对肝癌细胞增殖作用的影响[J]. 江苏大学学报(医学版), 2009, 19(6): 475-479.
[13] 谭家驹, 汤丽霞, 杨光, 等. 积雪草酸在制备药物方面的用途[P]. 中国专利, CN1943579A. 2007-04-11.
[14] 汤丽霞, 杨光, 谭家驹. 积雪草酸抑制HSC2-T6细胞I型胶原蛋白表达[J]. 第四军医大学学报, 2007, 28(13): 1178-1180.
[15] Hsu, Y.L., Kuo, P.L. and Lin, L.T. (2005) Asiatic Acid, a Triterpene, Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast Cancer Cells. Journal of Pharmacology and Experimental Therapeutic, 313, 333-344. http://dx.doi.org/10.1124/jpet.104.078808
[16] Jew, S.S., Park, H.G. and Kim, H.D. (1998) Preparation of Asiatic Acid Derivatives Having Modified A-Ring as Anticancer and Liver-Protecting Agents. WO: 98/23575.
[17] 孙宏斌, 张丽颖, 柳军. 熊果烷型五环三萜氨基酸衍生物制备方法及其医药用途[P]. 中国专利, CN101337984A. 2009-01-07.
[18] 孟艳秋, 赵敏杰, 张译, 刘立伟, 刘冬莹. 积雪草酸C2、C3、C23、C28衍生物的合成及其体外抗肿瘤活性研究[J]. 现代药物与临床, 2015, 30(4): 355-361.
[19] 赵龙铉, 田明珠, 金礼吉, 等. 积雪草酸衍生物的合成与表征及体外抗癌活性的研究[J]. 有机化学, 2011, 31(5): 646-652.
[20] 陈海生. 有机酸铂盐及其制备方法和在制备抗癌药物中的应用[P]. 中国专利, CN101289467A. 2008-10-22.
[21] 张蓉仙, 朱禹, 郭文洁, 等. 线粒体靶向的积雪草酸稀土配合物的合成及抗肿瘤活性[J]. 化学试剂, 2009, 31(12): 961-963.
[22] 姚其正, 李晶晶, 李耐三. 具有抗肿瘤作用的13-正-辛基小蘗碱新衍生物[P]. 中国专利, CN101012227A. 2007-08-08.
[23] 林娜, 高静, 方春钱. 积雪草酸与化疗药物联用抗肿瘤效应的初步研究[J]. 江苏大学学报(医学版), 2008, 18(6): 494-497.