氯甲基吡啶衍生物的工业化生产方法

Industrial Production Methods of Chloromethylpyridine Derivatives

摘要: 针对现有技术存在的问题，本文提供一种生产成本相对较低、对环境友好、对废物进行最大限度的循环利用的氯甲基吡啶衍生物的工业化生产方法。该生产工艺主要分为N-氧化、硝化、亲核取代、重排水解和氯甲基化五个工段。

Abstract: In view of the problems existing in the prior technology, this paper provides an industrial produc-tion method of chloromethylpyridine derivatives. The synthetic product of this method is relatively low in cost, friendly to environment, and can make the best use of waste. The production process is divided into five sections: N-oxidation, nitration, nucleophilic substitution, rearrangement hydrolysis and chloromethylation.