超声加速下2-苯基咪唑啉的高效合成
Rapid and Efficient Synthesis of 2-Phenyl Imidazolines under Ultrasonic Acceleration
摘要:
目的:快速高效且温和地合成2-苯基咪唑啉衍生物。方法:苯甲醛及取代苯甲醛为反应底物,和乙二胺在NBS的催化下,以超声合成各类2-苯基咪唑啉。结果:以二氯甲烷15毫升为反应溶剂,超声条件为25 min,反应结束直接过滤即得产物,产率为78.1%~99%。结论:该方法可以迅速温和地制备该类小分子化合物。
Abstract:
Objective: To synthesize 2-phenylimidazoline derivatives rapidly and efficiently. Methods: Ben-zaldehyde and substituted benzaldehydes were used as the reaction substrate, and ethylenedia-mine was used as the catalyst to synthesize 2-phenylimidazolines by ultrasound. Results: 15 ml dichloromethane as the reaction solvent, reaction under ultrasonic conditions for 25 min, after the termination of the reaction directly filtered product, the yield was 78.1% - 99%. Conclusion: This method can rapidly and mildly prepare such small molecular compounds.
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