失眠患者的抑制控制功能受损及其脑机制
The Impairment and Brain Mechanism on Inhibitory Control Function of Insomnia Disorder
DOI: 10.12677/AP.2017.73042, PDF, HTML, XML,  被引量 下载: 2,508  浏览: 3,137  国家自然科学基金支持
作者: 赵文瑞, 喻 婧, 雷 旭：西南大学心理学部，重庆；认知与人格教育部重点实验室，重庆
关键词: 失眠；注意控制；反应抑制；认知抑制；脑机制；Insomnia； Attention Control； Response Inhibition； Cognitive Inhibition； Brain Mechanism
摘要: 失眠的发生和维持与抑制控制功能受损息息相关。失眠患者抑制控制受损表现在注意控制、反应抑制和认知抑制三方面，其中注意控制受损得到多数研究的证实。认知抑制和反应抑制是否受损尚存争议，但失眠患者存在前额叶、海马、丘脑等脑区静息态结构和功能的受损以及任务态下前额叶的激活不足，都提示失眠患者可能有认知抑制和反应抑制能力的受损。右侧额中回结构和功能的受损可能是这三种抑制控制功能受损的共同脑机制。未来的研究应对失眠患者抑制控制功能受损进行干预，推进其认知抑制的研究，揭示失眠持续时间、严重程度和抑制控制功能的关系，力图深入探讨失眠患者抑制控制功能受损的原因及干预方法。
Abstract: The impairment of inhibitory control plays an important role in the development and mainten-ance of insomnia. The injury on inhibitory control of insomnia disorder included attention control, response inhibition, and cognitive inhibition, but most researches focused on the injury of attention control. The damage of cognitive inhibition and response inhibition is remaining controversial. However, the damage of structure and function in prefrontal cortex, hippocampus, and thalamus in resting state, and prefrontal hypoactivation in task may point out the impairment. The common mechanisms of the three injury inhibitory control functions may be derived from right middle frontal gyri. Future researches need focus on the intervention on impaired inhibitory control, promote the research of cognitive inhibition in patients with insomnia, and investigate the relationship between inhibitory control, insomnia duration and its severity. Thus we can fully explore the causes of the impaired inhibitory control and find its corresponding intervention methods.
文章引用：赵文瑞, 喻婧, 雷旭 (2017). 失眠患者的抑制控制功能受损及其脑机制. 心理学进展, 7(3), 328-340. https://doi.org/10.12677/AP.2017.73042

参考文献

[1] 汪玉林, 雷旭(2015). 基于Think/No-think范式的动机性遗忘研究: 行为与脑机制. 心理科学, (5), 1058-1066.
[2] 王曼, 陶嵘, 胡姝婧, 朱旭(2011). 注意偏向训练: 起源, 效果与机制. 心理科学进展, 3, 390-397.
[3] Altena, E., Van Der Werf, Y. D., Sanz-Arigita, E. J., Voorn, T. A., Rombouts, S. A. R. B., Kuijer, J. P. A., & Van Someren, E. J. W. (2008). Prefrontal Hypoactivation and Recovery in Insomnia. Sleep, 31, 1271-1276.
[4] Altena, E., Vrenken, H., Van Der Werf, Y. D., van den Heuvel, O. A., & Van Someren, E. J. W. (2010). Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study. Biological Psychiatry, 67, 182-185.
[5] American Academy of Sleep Medicine (2014). International Classification of Sleep Disorders (3rd ed.). Darien, IL: American Academy of Sleep Medicine.
[6] Anderson, M. C., & Green, C. (2001). Suppressing Unwanted Memories Byexecutive Control. Nature, 410, 366-369.
https://doi.org/10.1038/35066572
[7] Anderson, M. C., Ochsner, K. N., Kuhl, B., Cooper, J., Robertson, E., Gabrieli, S. W., Glover, G. H., & Gabrieli, J. D. E. (2004). Neural Systems Underlying the Suppression of Unwanted Memories. Science, 303, 232-235.
https://doi.org/10.1126/science.1089504
[8] Aron, A. R., & Poldrack, R. A. (2006). Cortical and Subcortical Contributions to Stop Signal Response Inhibition: Role of the Subthalamic Nucleus. The Journal of Neuroscience, 26, 2424-2433.
https://doi.org/10.1523/JNEUROSCI.4682-05.2006
[9] Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004). Inhibition and the Right Inferior Frontal Cortex. Trends in Cognitive Sciences, 8, 170-177.
[10] Baglioni, C., Lombardo, C., Bux, E., Hansen S., Salveta C., Biello S., Violani, C., & Espie, C. A. (2010). Psychophysiological Reactivity to Sleep-Related Emotional Stimuli in Primary Insomnia. Behaviour Research and Theraphy, 48, 467-475.
[11] Baglioni, C., Spiegelhaider, K., Regen, W., Feige, B., Nissen, C., Lombardo, C., Violani, C., Hennig, J., & Riemann, D. (2014). Insomnia Disorder Is Associated with Increased Amygdala Reactivity to Insomnia-Related Stimuli. Sleep, 37, 1907-1917.
https://doi.org/10.5665/sleep.4240
[12] Barclay, N. L., & Ellis, J. G. (2013). Sleep-Related Attentional Bias in Poor versus Good Sleepers Is Independent of Affective Valence. Journal of Sleep Research, 22, 414-421.
https://doi.org/10.1111/jsr.12035
[13] Bonnet, M. H., & Arand, D. L. (2010). Hyperarousal and Insomnia: State of the Science. Sleep Medicine Reviews, 14, 9-15.
[14] Booth, J. R., Burman, D. D., Meyer, J. R., Gitelman, D. R., Parrish, T. B., & Mesulam, M. M. (2004). Development of Brain Mechanisms for Processing Orthographic and Phonologic Representations. Journal of Cognitive Neuroscience, 16, 1234-1249.
https://doi.org/10.1162/0898929041920496
[15] Browning, M., Holmes, E. A., & Harmer, C. J. (2010). The Modification of Attentional Bias to Emotional Information: A Review of the Techniques, Mechanisms, and Relevance to Emotional Disorders. Cognitive, Affective, & Behavioral Neuroscience, 10, 8-20.
https://doi.org/10.3758/CABN.10.1.8
[16] Brydges, C. R., Clunies-Ross, K., Clohessy, M., Lo, Z. L., Nguyen, A., Rousset, C., Whitelaw, P., Yeap, Y. J., & Fox, A. M. (2012). Dissociable Components of Cognitive Control: An Event-Related Potential (ERP) Study of Response Inhibition and Interference Suppression. PLoS ONE, 7, e34482.
https://doi.org/10.1371/journal.pone.0034482
[17] Carney, C. E., Harris, A. L., Moss, T. G., & Edinger, J. D. (2010). Distinguishing Rumination from Worry in Clinical Insomnia. Behaviour Research and Therapy, 48, 540-546.
[18] Castaneda, A. E., Tuulio-Henriksson, A., Marttunen, M., Suvisaari, J., & Lönnqvist, J. (2008). A Review on Cognitive Impairments in Depressive and Anxiety Disorders with a Focus on Young Adults. Journal of Affective Disorders, 106, 1-27.
[19] Cisler, J. M., & KosterE. H. W. (2010). Mechanisms of Attentional Biases towards Threat in Anxiety Disorders: An Integrative Review. Clinical Psychology Review, 30, 203-216.
[20] Cohen, N., Mor, N., Henik, A. et al. (2015). Linking Executive Control and Emotional Response a Training Procedure to Reduce Rumination. Clinical Psychological Science, 3, 15-25.
https://doi.org/10.1177/2167702614530114
[21] Covassin, N., de Zambotti, M., Sarlo M., De Min Tona, G., Sarasso, S., & Steqaqno, L. (2011). Cognitive Performance and Cardiovascular Markers of Hyperarousal in Primary Insomnia. International Journal of Psychophysiology, 80, 79-86.
[22] Dai, X.-J., Peng, D.-C., Gong, H.-H., Wan, A.-L., Nie, X., Li, H.-J., & Wang, Y.-X.J. (2014). Altered Intrinsic Regional Brain Spontaneous Activity and Subjective Sleep Quality in Patients with Chronic Primary Insomnia: A Resting-State fMRI Study. Neuropsychiatric Disease and Treatment, 10, 2163-2175.
https://doi.org/10.2147/NDT.S69681
[23] Depue, B. E., Curran, T., & Banich, M. T. (2007). Prefrontal Regions Orchestrate Suppression of Emotional Memories via a Two-Phase Process. Science, 317, 215-219.
https://doi.org/10.1126/science.1139560
[24] Depue, B. E., Orr, J. M., Smolker, H. R., Naaz, F., & Banich, M. T. (2016). The Organization of Right Prefrontal Networks Reveals Common Mechanisms of Inhibitory Regulation across Cognitive, Emotional, and Motor Processes. Cerebral Cortex, 26, 1634-1646.
https://doi.org/10.1093/cercor/bhu324
[25] Diamond, A. (2013). Executive Functions. Annual Review of Psychology, 64, 135-168.
https://doi.org/10.1146/annurev-psych-113011-143750
[26] Duann, J.-R., Ide, J. S., Luo, X., & Li, C. R. (2009). Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Pre-Supplementary Motor Area in Stop Signal Inhibition. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 29, 10171-10179.
https://doi.org/10.1523/JNEUROSCI.1300-09.2009
[27] Edinger, J. D., & Means, M. K. (2005). Cognitive-Behavioral Therapy for Primary Insomnia. Clinical Psychology Review, 25, 539-558.
[28] Espie, C. A., Broomfield, N. M., MacMahon, K. M. A., Macphee, L. M., & Taylor, L. M. (2006). The Attention-Intention-Effort Pathway in the Development of Psychophysiologic Insomnia: A Theoretical Review. Sleep Medicine Reviews, 10, 215-245.
[29] Eysenck, M. W., Derakshan, N., Santos, R., & Calvo, M. G. (2007). Anxiety and Cognitive Performance: Attentional Control Theory. Emotion, 7, 336-353.
https://doi.org/10.1037/1528-3542.7.2.336
[30] Ferreira, O. D. L., & de Almondes, K. M. (2014). The Executive Functions in Primary Insomniacs: Literature Review. Perspectivas en Psicología, 11, 1-9.
[31] Fortier-Brochu, É., Beaulieu-Bonneau, S., Ivers, H., & Morin, C. M. (2012). Insomnia and Daytime Cognitive Performance: A Meta-Analysis. Sleep Medicine Reviews, 16, 83-94.
[32] Hakamata, Y., Lissek, S., Bar-Haim, Y., Britton, J. C., Fox, N., Leibenluft, E., Ernst, M., & Pine, D. S. (2010). Attention Bias Modification Treatment: A Meta-Analysis towards the Establishment of Novel Treatment for Anxiety. Biological Psychiatry, 68, 982-990.
[33] Harris, K., Spiegelhalder, K., Espie, C. A., MacMahon, K. M. A., Woods, H. C., & Kyle, S. D. (2015). Sleep-Related Attentional Bias in Insomnia: A State-of-the-Science Review. Clinical Psychology Review, 42, 16-27.
[34] Harvey, A. G. (2002). A Cognitive Model of Insomnia. Behaviour Research Therapy, 40, 869-893.
[35] Jacobs, G. D., Pace-Schott, E. F., Stickgold, R., & Otto, M. W. (2004) Cognitive Behavior Therapy and Pharmacotherapy for Insomnia: A Randomized Controlled Trial and Direct Comparison. Archives Internal Medicine, 164, 1888-1896.
https://doi.org/10.1001/archinte.164.17.1888
[36] Jain, S., Shapiro S. L., Swanick, S., Roesch, S. C., Mills, P. J., Bell, L., &Schwartz, G. E. (2007). A Randomized Controlled Trial of Mindfulness Meditation versus Relaxation Training: Effects on Distress, Positive States of Mind, Rumination, and Distraction. Annals of Behavioral Medicine, 33, 11-21.
https://doi.org/10.1207/s15324796abm3301_2
[37] Jansson-Fröjmark, M., Bermås, M., & Kjellén, A. (2013). Attentional Bias in Insomnia: The Dot-Probe Task with Pictorial Stimuli Depicting Daytime Fatigue/Malaise. Cognitive Therapy and Research, 37, 534-546.
https://doi.org/10.1007/s10608-012-9486-z
[38] Joo, E. Y., Noh, H. J., Kim, J.-S., Koo, D. L., Kim, D., Hwang, K. J., Kim J. Y., Kim S.T., Kim, M. R., & Hong, S. B. (2013). Brain Gray Matter Deficits in Patients with Chronic Primary Insomnia. Sleep, 36, 999-1007.
https://doi.org/10.5665/sleep.2796
[39] Joormann, J. (2006). Differential Effects of Rumination and Dysphoria on the Inhibition of Irrelevant Emotional Material: Evidence from a Negative Priming Task. Cognitive Therapy and Research, 30, 149-160.
https://doi.org/10.1007/s10608-006-9035-8
[40] Kane, M. J., & EngleR. W. (2002). The role of Prefrontal Cortex in Working-Memory Capacity, Executive Attention, and General Fluid Intelligence: An Individual-Differences Perspective. Psychonomic Bulletin & Review, 9, 637-671.
https://doi.org/10.3758/BF03196323
[41] Koster, E. H., Lisnyder, E. D., Derakshan, Z., & Raedt, R. D. (2011). Understanding Depressive Rumination from a Cognitive Science Perspective: The Impaired Disengagement Hypothesis. Clinical Psychology Review, 31, 138-145.
[42] Li, C.-S.R., Yan, P., Sinha, R., & Lee, T.-W. (2008). Sub-Cortical Processes of Motor Response Inhibition during a Stop Signal Task. Neuroimage, 41, 1352-1363.
[43] Li, Y., Wang, E., Zhang, H., Dou, S., Liu, L., Tong, L., Lei Y., Wang, M., Xu, J., Shi, D., & Zhang, Q. (2014). Functional Connectivity Changes between Parietal and Prefrontal Cortices in Primary Insomnia Patients: Evidence from Resting-State fMRI. European Journal of Medical Research, 19, 1-7.
[44] Logan, G. D., & Cowan, W. B. (1984). On the Ability to Inhibit Thought and Action: A Theory of an Act of Control. Psychological Review, 91, 295-327.
https://doi.org/10.1037/0033-295X.91.3.295
[45] Lundh, L.-G., Froding, A., Gyllenhammar, L., Broman, J.-E., & Hetta, J. (1997). Cognitive Bias and Memory Performance in Patients with Persistent Insomnia. Cognitive Behaviour Therapy, 26, 27-35.
https://doi.org/10.1080/16506079708412033
[46] MacMahon, K. M., Broomfield, N.M., & Espie, C. A. (2006). Attention Bias for Sleep-Related Stimuli in Primary Insomnia and Delayed Sleep Phase Syndrome Using the Dot-Probe Task. Sleep, 29, 1420.
[47] Marchetti, L. M., Biello, S. M., Broomfield, N. M., Macmahon, K. M., & Espie C.A. (2006). Who Is Pre-Occupied with Sleep? A Comparison of Attention Bias in People with Psychophysiological Insomnia, Delayed Sleep Phase Syndrome and Good Sleepers Using the Induced Change Blindness Paradigm. Journal of Sleep Research, 15, 212-221.
https://doi.org/10.1111/j.1365-2869.2006.00510.x
[48] Miller, E. K., & Cohen, J. D. (2001). An Integrative Theory of Prefrontal Cortex Function. Annual Review of Neuroscience, 24, 167-202.
https://doi.org/10.1146/annurev.neuro.24.1.167
[49] Neylan, T. C., Mueller, S. G., Wang, Z., Metzler, T. J., Lenoci, M., Marmar, C. R., Weiner, M. W., & Schuff, N. (2010). Insomnia Severity Is Associated with a Decreased Volume of the CA3/Dentate Gyrus Hippocampal Subfield. Biological Psychiatry, 68, 494-496.
[50] Nigg, J. T. (2000). On Inhibition/Disinhibition Indevelopmental Psychopathology: Views from Cognitive and Personality Psychology and a Working Inhibition Taxonomy. Psychological Bulletin, 126, 220-246.
https://doi.org/10.1037/0033-2909.126.2.220
[51] Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004). Functional Neuroimaging Evidence for Hyperarousal in Insomnia. American Journal of Psychiatry, 161, 2126-2128.
https://doi.org/10.1176/appi.ajp.161.11.2126
[52] Noh, H. J., Joo, E. Y., Kim, S. T., Yoon, S. M., Koo, D. L., Kim, D., Lee, G.-H., & Hong, S. B. (2012). The Relationship between Hippocampal Volume and Cognition in Patients with Chronic Primary Insomnia. Journal of Clinical Neurology, 8, 130-138.
https://doi.org/10.3988/jcn.2012.8.2.130
[53] Nota, J. A., & Coles, M. E. (2015). Duration and Timing of Sleep Are Associated with Repetitive Negative Thinking. Cognitive Therapy and Research, 39, 253-261.
https://doi.org/10.1007/s10608-014-9651-7
[54] Orff, H. J., Drummond, S. P. A., Nowakowski, S., & Perlis, M. L. (2007). Discrepancy between Subjective Symptomatology and Objective Neuropsychological Performance in Insomnia. Sleep, 30, 1205-1211.
[55] Riemann, D., Spiegelhalder, K., Fiege, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010). The Hyperarousal Model of Insomnia: A Review of the Concept and Its Evidence. Sleep Medicine Reviews, 14, 19-31.
[56] Riemann, D., Voderholzer, U., Spiegelhalder, K., Hornyak, M., Buysse, D. J., Nissen, C., Hennig, J., Perils, M., van Elst, L. T., & Feige, B. (2007). Chronic Insomnia and MRI-Measured Hippocampal Volumes: A Pilot Study. Sleep, 30, 955-658.
[57] Sagaspe, P., Philip, P., & Schwartz, S. (2007). Inhibitory Motor Control in Apneic and Insomniac Patients: A Stop Task Study. Journal of Sleep Research, 16, 381-387.
https://doi.org/10.1111/j.1365-2869.2007.00607.x
[58] Shekleton, J. A., Rogers, N. L., & Rajaratnam, S. M. W. (2010). Searching for the Daytime Impairments of Primary Insomnia. Sleep Medicine Reviews, 14, 47-60.
[59] Smith, E. E., & Jonides, J. (1999). Storage and Executive Processes in the Frontal Lobes. Science, 283, 1657-1661.
https://doi.org/10.1126/science.283.5408.1657
[60] Snyder, H. R. (2013). Major Depressive Disorder Is Associated with Broad Impairments on Neuropsychological Measures of Executive Function: A Meta-Analysis and Review. Psychological Bulletin, 139, 81-132.
https://doi.org/10.1037/a0028727
[61] Spiegelhalder, K., Espie, C., Nissen, C., & Riemann, D. (2008). Sleep-Related Attentional Bias in Patients with Primary Insomnia Compared with Sleep Experts and Healthy Controls. Journal of Sleep Research, 17, 191-196.
https://doi.org/10.1111/j.1365-2869.2008.00641.x
[62] Spiegelhalder, K., Kyle, S. D., Feige, B., Prem, M., Nissen, C., Espie, C. A., & Riemann, D. (2010). The Impact of Sleep-Related Attentional Bias on Polysomnographically Measured Sleep in Primary Insomnia. Sleep, 33, 107-112.
[63] Spiegelhalder, K., Regen, W., Baglioni, C., Riemann, D., & Winkelman, J. W. (2013). Neuroimaging Studies in Insomnia. Current Psychiatry Reports, 15, 1-6.
https://doi.org/10.1007/s11920-013-0405-0
[64] Takano, K., lijima, Y., & Tanno, Y. (2012). Repetitive Thought and Self-Reported Sleep Disturbance. Behavior Therapy, 43, 779-789.
[65] Tavor, I., Jones, O. P., Mars, R. B., Smith, S. M., Behrens, T. E., & Jbabdi, S. (2016). Task-Free MRI Predicts Individual Differences in Brain Activity during Task Performance. Science, 352, 216-220.
https://doi.org/10.1126/science.aad8127
[66] Taylor, L. M., Espie, C. A., & White, C. A. (2003). Attentional Bias in People with Acute versus Persistent Insomnia Secondary to Cancer. Behavioral Sleep Medicine, 1, 200-212.
https://doi.org/10.1207/S15402010BSM0104_3
[67] Thomsen, D. K., Mehlsen, M. Y., Christensen, S., & Zachariae, R. (2003). Rumination—Relationship with Negative Mood and Sleep Quality. Personality and Individual Differences, 34, 1293-1301.
[68] Verweij, I. M., Romeijn, N., Smit, D. J., Piantoni, G., Van Someren, E. J., & van der Werf, Y. D. (2014). Sleep Deprivation Leads to a Loss of Functional Connectivity in Frontal Brain Regions. BMC Neuroscience, 15, 88.
https://doi.org/10.1186/1471-2202-15-88
[69] Whitmer, A. J., & Banich, M. T. (2007). Inhibition versus Switching Deficits in Different Forms of Rumination. Psychological Science, 18, 546-553.
https://doi.org/10.1111/j.1467-9280.2007.01936.x
[70] Wiecki, T. V., & Frank, M. J. (2013). A Computational Model of Inhibitory Control in Frontal Cortex and Basal Ganglia. Psychological Review, 120, 329.
https://doi.org/10.1037/a0031542
[71] Woods, H., Marchetti, L. M., Biello, S. M., & Espie, C. A. (2009). The Clock as a Focus of Selective Attention in Those with Primary Insomnia: An Experimental Study Using a Modified Posner Paradigm. Behaviour Research Therapy, 47, 231-236.
[72] Xin, F., & Lei, X. (2015). Competition between Frontoparietal Control and Default Networks Supports Social Working Memory and Empathy. Social Cognitive and Affective Neuroscience, 10, 1144-1152.
https://doi.org/10.1093/scan/nsu160
[73] Yang, W., Zhang J. X., Ding, Z., & Xiao, L. (2016). Attention Bias Modification Treatment for Adolescents with Major Depression: A Randomized Controlled Trial. Journal of the American Academy of Child & Adolescent Psychiatry, 55, 208-218.e202.
[74] Zou, Q., Ross, T. J., Gu, H., Geng, X., Zuo, X.-N., Hong, L. E., Gao, J.-H., Stein, E. A., Zang, Y.-F., & Yang, Y. (2013). Intrinsic Resting-State Activity Predicts Working Memory Brain Activation and Behavioral Performance. Human Brain Mapping, 34, 3204-3215.
https://doi.org/10.1002/hbm.22136