脑卒中肌张力增高与多巴胺神经递质水平关系的研究

Study on the Relationship between the Increased Muscle Tone of Stroke and the Level of Dopamine Neurotransmitter

摘要: 目的：探究分析脑卒中患者出现肌张力障碍后，体内多巴胺递质水平的变化以及两者之间的相关性。方法：选取2015年1月至2016年1月期间在我院收治的脑卒中后肌张力障碍在II级以上患者59例作为观察组，59例脑卒中后肌张力在II级以下患者作为对照组，并对两组患者进行康复治疗。使用头颅磁共振波谱分析对研究对象神经递质多巴胺(DA)、乙酰胆碱(Cho)以及脑部代谢产物如N-乙酰天门冬氨酸(NAA)、乳酸(Lac)等指标进行检测，分析观察其指标变化水平。结果：观察组DA的含量与对照组相比显著升高，Cho、NAA的峰值显著降低，Lac的含量显著升高，且两组之间的差异有统计学意义(P < 0.05)。结论：肌张力障碍患者脑部的神经递质水平和代谢产物存在失衡，提示其与肌张力障碍有一定的相关性，可为临床脑卒中患者的治疗及预后提供重要的临床研究基础。

Abstract: Objective: To explore and analyze the changes of dopamine level after stroke patients presenting dystonia and the correlation between them. Methods: 59 stroke patients with dystonia of level II or above who were treated in our hospital from January 2015 to January 2016 were included in observation group, and 59 stroke patients with dystonia below level II were included in control group, and both of the two groups of patients were treated for rehabilitation. Head magnetic resonance-spectroscopy was used to examine the neurotransmitters like dopamine (DA) and acetylcholine (Cho) and the brain metabolites like N-acetyl aspartic acid (NAA), lactic acid (Lac) and the changes of these indicators were observed and analyzed. Results: Compared to the control group, the content of DA in the observation group was significantly increased, and the peak values of Cho and NAA were significantly decreased and the content of Lac was significantly increased; there was statistical significance in the difference between the two groups (P < 0.05). Conclusion: The levels of neurotransmitter and brain metabolites of dystonia patients were imbalanced, which suggested that there was certain correlation with dystonia, providing an important basis for clinical research on the treatment and prognosis of stroke patients.