治疗和未治疗的轻度子宫颈上皮内瘤变的临床转归：Meta分析

Clinical Outcomes of Treated and Untreated Mild Cervical Intraepithelial Neo-plasia: Meta Analysis

摘要: 综合评价轻度宫颈上皮内瘤变(CIN I)经治疗和未治疗的临床转归。方法：以关键词CIN I + 随访(follow up)进行计算机检索维普中文科技期刊数据库、维普期刊资源整合服务平台、万方中华医学会数字化期刊、CNKI中国学术期刊网络出版总库、PUBMED (MEDLINE数据库)，纳入研究CIN I在临床转归的文献，RevMan 5.3版软件处理分析。结果：符合要求的文献共纳入16篇，CIN I共计2325例，平均随访13.7个月。治疗组共1297例，其中消退960例(消退率为74.0%)，持续或进展337例(持续及进展率为26.0%)；未治疗组共1028例，其中自然消退602例(消退率为59.0%)，持续或进展426例(持续进展率为41.0%)。Meta分析结果显示，经治疗的CIN I消退率比值是非治疗组的4.69倍，持续及进展率比值是0.21倍。结论：CIN I经治疗后消退的效果明显，对CIN I积极治疗可以有效防治CIN进展为宫颈癌。

Abstract: To evaluate the clinical outcomes of the treated and untreated mild cervical intraepithelial neo-plasia (cervical intraepithelial neoplasia grade I, CIN I). Methods: Using keywords (CIN I + follow up), CQVIP, WanFang, CNKI and PubMed database were computer retrieved. The references about the clinical outcomes of CIN I were included. RevMan Version 5.3 Software Processing Analysis. Results: 16 articles were included in the standard. CIN I totaled 2325 cases, with an average follow-up of 13.7 months. 1297 cases belonged to the treatment group, in which 960 cases were faded (faded rate was 74%), and 337 cases were sustained or progressed (sustained to progression rate was 26%); The untreated group 1028 cases, in which 602 cases were faded (faded rate was 59%), and 426 cases were sustained or progressed (sustained to progression rate was 41%). Meta analysis showed that the faded rate of CIN I was 4.69 times, and the ratio of sustained to progression was 0.21 times, as in the non-treatment group. Conclusion: The faded effect of the treatment for CIN I might be significantly obvious. The active treatment of CIN I can effectively prevent CIN I from the progression to cervical cancer.