双相障碍的心理理论研究
Theory of Mind in Bipolar Disorder
DOI: 10.12677/AP.2017.711164, PDF, HTML, XML, 下载: 1,781  浏览: 5,104 
作者: 曾 晶：深圳大学，广东 深圳；刘铁榜：深圳市康宁医院，广东 深圳
关键词: 双相障碍；心理理论；内表型；神经认知功能；社会功能；Bipolar Disorder； Theory of Mind； Endophenotype； Neurocognitive； Social Function
摘要: 对双相障碍的心理理论损害是否为内表型的探讨有利于寻找病因及适当的治疗方法。文章在简要梳理相关定义、研究范式和有关理论的基础上，重点介绍了双相障碍心理理论的研究现状和相关影响因素。目前研究表明双相障碍发作期患者存在心理理论的损害，随后从疾病进程和家系研究两方面探讨其作为内表型的可能性，并探究神经认知功能、社会功能和心理理论的关系。未来研究需提高心理理论任务效度，进行首发、超高危人群和纵向研究，探究其神经解剖机制，从干预和治疗的角度出发拓宽研究领域。
Abstract: The study of theory of mind in bipolar disorder is helpful to find the cause and appropriate treatment. On the basis of introducing the relevant definition, research paradigm and theories, we aim to review the theory of mind in BD and its relevant factors. Currently research shows that the deficits in theory of mind exit in acute patients with BD. Then, we explored the possibility of theory of mind as a potential candidate endophenotype for BD from the disease process and first degree relative research, and the relationship among neurocognitive function, social function and theory of mind. The future research should improve the validity of paradigm, and there is a need for first-episode studies and longitudinal studies comparing the developmental course of ToM and other social cognition abilities in individuals at risk for BP, and also needs to widen research fields from the views of intervening and curing.
文章引用：曾晶, 刘铁榜 (2017). 双相障碍的心理理论研究. 心理学进展, 7(11), 1319-1328. https://doi.org/10.12677/AP.2017.711164

参考文献

[1] 陈学全, 汪凯, 董毅(2012). 精神分裂症社会认知功能研究进展. 中国神经精神疾病杂志, 38(8), 502-505.
[2] 陈楚侨, 杨斌让, 王亚(2008). 内表型方法在精神疾病研究中的应用. 心理科学进展, 16(3), 378-391.
[3] 陀柠瑜, 刘铁榜, 杨海晨, 荣晗, 张建, 沈其杰(2013). 双相障碍患者社会认知功能的比较研究. 中华精神科杂志, 46(6), 330-332.
[4] 朱玥, 马燕桃, 于欣(2012). 双相障碍神经认知研究进展. 国际精神病学杂志, (1), 23-27.
[5] Bora, E., & Özerdem, A. (2017). Social Cognition in First-Degree Relatives of Patients with Bipolar Disorder: A Meta-Analysis. European Neuropsychopharmacology the Journal of the European College of Neuropsychopharmacology, 27, 297-300. https://doi.org/10.1016/j.euroneuro.2017.02.009
[6] Bora, E., Bartholomeusz, C., & Pantelis, C. (2016a). Meta-Analysis of Theory of Mind (ToM) Impairment in Bipolar Disorder. Psychological Medicine, 46, 253-264. https://doi.org/10.1017/S0033291715001993
[7] Bora, E., & Pantelis, C. (2016b). Social Cognition in Schizophrenia in Comparison to Bipolar Disorder : A Meta-Analysis. Schizophrenia Research, 175, 72-78. https://doi.org/10.1016/j.schres.2016.04.018
[8] Bora, E., & Berk, M. (2015). Theory of Mind in Major Depressive Disorder: A Meta-Analysis. Journal of Affective Disorders, 191, 49. https://doi.org/10.1016/j.jad.2015.11.023
[9] Bora, E., Yücel, M., & Pantelis, C. (2010). Neurocognitive Markers of Psychosis in Bipolar Disorder : A Meta-Analytic Study. Journal of Affective Disorders, 127, 1-9. https://doi.org/10.1016/j.jad.2010.02.117
[10] Bora, E., Yucel, M., & Pantelis, C. (2009). Cognitive Endophenotypes of Bipolar Disorder: A Meta-Analysis of Neuropsychological Deficits in Euthymic Patients and Their First-Degree Relatives. Journal of Affective Disorders, 113, 1-20. https://doi.org/10.1016/j.jad.2008.06.009
[11] Bora, E., Eryavuz, A., Kayahan, B., Sungu, G., & Veznedaroglu, B. (2006). Social Functioning, Theory of Mind and Neurocognition in Outpatients with Schizophrenia; Mental State Decoding May Be a Better Predictor of Social Functioning than Mental State Reasoning. Psychiatry Research, 145, 95-103. https://doi.org/10.1016/j.psychres.2005.11.003
[12] Bora, E., Vahip, S., Gonul, A. S., Akdeniz, F., Alkan, M., Ogut, M., & Eryavuz, A. (2005). Evidence for Theory of Mind Deficits in Euthymic Patients with Bipolar Disorder. Acta Psychiatrica Scandinavica, 112, 110-116. https://doi.org/10.1111/j.1600-0447.2005.00570.x
[13] Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The “Reading the Mind in the Eyes” Test Revised Version: A Study with Normal Adults, and Adults with Asperger Syndrome or High-Functioning Autism. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 42, 241-251. https://doi.org/10.1111/1469-7610.00715
[14] Baron-Cohen, S., O’riordan, M., Stone, V., Jones, R., & Plaisted, K. (1999). Recognition of Faux Pas by Normally Developing Children and Children with Asperger Syndrome or High-Functioning Autism. Journal of Autism and Developmental Disorders, 29, 407-418. https://doi.org/10.1023/A:1023035012436
[15] Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the Autistic Child Have a “Theory of Mind?” Cognition, 21, 37-46. https://doi.org/10.1016/0010-0277(85)90022-8
[16] Caletti, E., Paoli, R. A., Fiorentini, A., Cigliobianco, M., Zugno, E., Serati, M., & Altamura, A. C. (2013). Neuropsychology, Social Cognition and Global Functioning among Bipolar, Schizophrenic Patients and Healthy Controls: Preliminary Data. Frontiers in Human Neuroscience, 7, 661. https://doi.org/10.3389/fnhum.2013.00661
[17] Corcoran, R., Mercer, G., & Frith, C. D. (1995). Schizophrenia, Symptomatology and Social Inference: Investigating “Theory of Mind” in People with Schizophrenia. Schizophrenia Research, 17, 5-13. https://doi.org/10.1016/0920-9964(95)00024-G
[18] Dickinson, D., Ramsey, M. E., & Gold, J. M. (2007). Overlooking the Obvious: A Meta-Analytic Comparison of Digit Symbol Coding Tasks and Other Cognitive Measures in Schizophrenia. Archives of General Psychiatry, 64, 532-542. https://doi.org/10.1001/archpsyc.64.5.532
[19] Duval, C., Bejanin, A., Piolino, P., Laisney, M., de La Sayette, V., Belliard, S. et al. (2012). Theory of Mind Impairments in Patients with Semantic Dementia. Brain: A Journal of Neurology, 135, 228-241. https://doi.org/10.1093/brain/awr309
[20] Fett, A. K., Viechtbauer, W., Dominguez, M. D., Penn, D. L., Van, O. J., & Krabbendam, L. (2011). The Relationship between Neurocognition and Social Cognition with Functional Outcomes in Schizophrenia: A Meta-Analysis. Neuroscience & Biobehavioral Reviews, 35, 573-588. https://doi.org/10.1016/j.neubiorev.2010.07.001
[21] Fisch, G. S. (2013). Autism and Epistemology IV: Does Autism Need a Theory of Mind? American Journal of Medical Genetics Part A, 161, 2464. https://doi.org/10.1002/ajmg.a.36135
[22] Frith, C. (1994). Theory of Mind in Schizophrenia. Brain Damage, Behaviour and Cognition Series. The Neuropsychology of Schizophrenia, 147-161.
[23] Gitlin, M. J., Swendsen, J., Heller, T. L., & Hammen, C. (1995). Relapse and Impairment in Bipolar Disorder. American Journal of Psychiatry, 152, 1635-1640. https://doi.org/10.1176/ajp.152.11.1635
[24] Golan, O., Baron-Cohen, S., & Golan, J. J. H. Y. (2006). The “Reading the Mind in Films” Task: Complex Emotion Recognition in Adults with and without Autism Spectrum Conditions. Social Neuroscience, 1, 111. https://doi.org/10.1080/17470910600980986
[25] Golan, O., Baron-Cohen, S., Hill, J. J., & Rutherford, M. D. (2007). The ‘Reading the Mind in the Voice’ Test-Revised: A Study of Complex Emotion Recognition in Adults with and without Autism Spectrum Conditions. Journal of Autism & Developmental Disorders, 37, 1096-1106. https://doi.org/10.1007/s10803-006-0252-5
[26] Gottesman, I. I., & Gould, T. D. (2003). The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions. American Journal of Psychiatry, 160, 636-645. https://doi.org/10.1176/appi.ajp.160.4.636
[27] Haag, S., Haffner, P., Quinlivan, E., Brüne, M., & Stamm, T. (2016). No Differences in Visual Theory of Mind Abilities between Euthymic Bipolar Patients and Healthy Controls. International Journal of Bipolar Disorders, 4, 20. https://doi.org/10.1186/s40345-016-0061-5
[28] Hamilton, M. (1967). Development of a Rating Scale for Primary Depressive Illness. British Journal of Clinical Psychology, 6, 278-296. https://doi.org/10.1111/j.2044-8260.1967.tb00530.x
[29] Hardy-Baylé, M. C. (1994). Organisation de l'action, phénomènes de conscience et représentation mentale de l'action chez des schizophrènes. Actualités psychiatriques, 24, 9-18.
[30] Harrington, L., Siegert, R. J., & McClure, J. (2005). Theory of Mind in Schizophrenia: A Critical Review. Cognitive Neuropsychiatry, 10, 249-286. https://doi.org/10.1080/13546800444000056
[31] Harvey, P. D., & Penn, D. (2010). Social Cognition: The Key Factor Predicting Social Outcome in People with Schizophrenia? Psychia-try-Interpersonal & Biological Processes, 7, 41.
[32] Hawken, E. R., Harkness, K. L., Lazowski, L. K., Summers, D., Khoja, N., Gregory, J. G., & Milev, R. (2016). The Manic Phase of Bipolar Disorder Significantly Impairs Theory of Mind Decoding. Psychiatry Research, 239, 275-280. https://doi.org/10.1016/j.psychres.2016.03.043
[33] Ioannidi, N., Konstantakopoulos, G., Sakkas, D., & Oulis, P. (2015). The Relationship of Theory of Mind with Symptoms and Cognitive Impairment in Bipolar Disorder: A Prospective Study. Psychiatrike = Psychiatriki, 26, 17-27.
[34] Kerr, N. (2003). Theory of Mind Deficits in Bipolar Affective Disorder. Journal of Affective Disorders, 73, 253-259. https://doi.org/10.1016/S0165-0327(02)00008-3
[35] Konstantakopoulos, G., Ploumpidis, D., Oulis, P., Patrikelis, P., Nikitopoulou, S., Papadimitriou, G. N. et al. (2013). The Relationship between Insight and Theory of Mind in Schizophrenia. Schizophrenia Research, 152, 217-222. https://doi.org/10.1016/j.schres.2013.11.022
[36] Lahera, G., Montes, J. M., Benito, A., Valdivia, M., Medina, E., Mirapeix, I., & Sáiz-Ruiz, J. (2008). Theory of Mind Deficit in Bipolar Disorder: Is It Related to a Previous History of Psychotic Symptoms? Psychiatry Research, 161, 309-317. https://doi.org/10.1016/j.psychres.2007.08.009
[37] Lahera, G., Ruiz-Murugarren, S., Iglesias, P., Ruiz-Bennasar, C., Herreria, E., Montes, J. M., & Fernandez-Liria, A. (2012). Social Cognition and Global Functioning in Bipolar Disorder. The Journal of Nervous and Mental Disease, 200, 135-141. https://doi.org/10.1097/NMD.0b013e3182438eae
[38] Lee, J., Altshuler, L., Glahn, D. C., Miklowitz, D. J., Ochsner, K., & Green, M. F. (2013). Social and Nonsocial Cognition in Bipolar Disorder and Schizophrenia: Relative Levels of Impairment. American Journal of Psychiatry, 170, 334-341. https://doi.org/10.1176/appi.ajp.2012.12040490
[39] Maróthi, R., & Kéri, S. (2014). Intuitive Physics and Intuitive Psychology (“Theory of Mind”) in Offspring of Mothers with Psychoses. PeerJ, 2, e330. https://doi.org/10.7717/peerj.330
[40] Martino, D. J., Strejilevich, S. A., Fassi, G., Marengo, E., & Igoa, A. (2011). Theory of Mind and Facial Emotion Recognition in Euthymic Bipolar I and Bipolar II Disorders. Psychiatry Research, 189, 379-384. https://doi.org/10.1016/j.psychres.2011.04.033
[41] McGlade, N., Behan, C., Hayden, J., O’Donoghue, T., Peel, R., Haq, F., & Donohoe, G. (2008). Mental State Decoding Mental State Reasoning as a Mediator between Cognitive and Social Function in Psychosis. British Journal of Psychiatry, 193, 77-78. https://doi.org/10.1192/bjp.bp.107.044198
[42] Olley, A. L., Malhi, G. S., Bachelor, J., Cahill, C. M., Mitchell, P. B., & Berk, M. (2005). Executive Functioning and Theory of Mind in Euthymic Bipolar Disorder. Bipolar Disorders, 7, 43-52. https://doi.org/10.1111/j.1399-5618.2005.00254.x
[43] Perner, J., & Wimmer, H. (1985). John Thinks That Mary Thinks: Attribution of Second-Order Beliefs by 5 - 10 Year Old Children. Journal of Experimental Child Psychology, 39, 437-471. https://doi.org/10.1016/0022-0965(85)90051-7
[44] Premack, D., & Woodruff, G. (1978). Does the Chimpanzee Have a Theory of Mind? Behavioral and Brain Sciences, 1, 515-526. https://doi.org/10.1017/S0140525X00076512
[45] Purcell, A. L., Phillips, M., & Gruber, J. (2013). In Your Eyes : Does Theory of Mind Predict Impaired Life Functioning in Bipolar Disorder ? Journal of Affective Disorders, 151, 1113-1119. https://doi.org/10.1016/j.jad.2013.06.051
[46] Purcell, S. M., Wray, N. R., Stone, J. L., Visscher, P. M., O’Donovan, M. C., Sullivan, P. F. et al. (2009). Common Polygenic Variation Contributes to Risk of Schizophrenia and Bipolar Disorder. Nature, 460, 748-752. https://doi.org/10.1038/nature08185
[47] Reynolds, M. T., Van Rheenen, T. E., & Rossell, S. L. (2014). Theory of Mind in First Degree Relatives of Individuals with Bipolar Disorder. Psychiatry Research, 219, 400-402. https://doi.org/10.1016/j.psychres.2014.05.041
[48] Rossell, S. L., & Van Rheenen, T. E. (2013). Theory of Mind Performance Using a Story Comprehension Task in Bipolar Mania Compared to Schizophrenia and Healthy Controls. Cognitive Neuropsychiatry, 18, 409-421. https://doi.org/10.1080/13546805.2012.725820
[49] Samamé, C., Martino, D. J., & Strejilevich, S. A. (2012). Social Cognition in Euthymic Bipolar Disorder: Systematic Review and Meta-Analytic Approach. Acta Psychiatrica Scandinavica, 125, 266-280. https://doi.org/10.1111/j.1600-0447.2011.01808.x
[50] Samamé, C., Martino, D. J., & Strejilevich, S. A. (2015). An Individual Task Meta-Analysis of Social Cognition in Euthymic Bipolar Disorders. Journal of Affective Disorders, 173, 146-153. https://doi.org/10.1016/j.jad.2014.10.055
[51] Thaler, N. S., Allen, D. N., Sutton, G. P., Vertinski, M., & Ringdahl, E. N. (2013). Differential Impairment of Social Cognition Factors in Bipolar Disorder with and without Psychotic Features and Schizophrenia. Journal of Psychiatric Research, 47, 2004-2010. https://doi.org/10.1016/j.jpsychires.2013.09.010
[52] Tohen, M., Waternaux, C. M., & Tsuang, M. T. (1990). Outcome in Mania. A 4-Year Prospective Follow-Up of 75 Patients Utilizing Survival Analysis. Archives of General Psychiatry, 47, 1106-1111. https://doi.org/10.1001/archpsyc.1990.01810240026005
[53] Van Rheenen, T. E., & Rossell, S. L. (2013). Picture Sequencing Task Performance Indicates Theory of Mind Deficit in Bipolar Disorder. Journal of Affective Disorders, 151, 1132-1134. https://doi.org/10.1016/j.jad.2013.07.009
[54] Wang, Y. G., Roberts, D. L., Liang, Y., Shi, J. F., & Wang, K. (2015). Theory-of-Mind Understanding and Theory-of-Mind Use in Unaffected First-Degree Relatives of Schizophrenia and Bipolar Disorder. Psychiatry Research, 230, 735-737. https://doi.org/10.1016/j.psychres.2015.10.026
[55] Wiener, D., Andrzejewska, M., Bodnar, A., & Rybakowski, J. (2011). Disturbances of the Theory of Mind and Empathy in Schizophrenia and Bipolar Affective Illness. Neuropsychiatriai Neuropsychologia, 6, 85-92.
[56] Willert, A., Mohnke, S., Erk, S., Schnell, K., Romanczuk-Seiferth, N., Quinlivan, E. et al. (2016). Alterations in Neural Theory of Mind Processing in Euthymic Patients with Bipolar Disorder and Unaffected Relatives. Bipolar Disorders, 17, 880-891. https://doi.org/10.1111/bdi.12352
[57] Wolf, F., Brune, M., & Assion, H.-J. (2010). Theory of Mind and Neurocognitive Functioning in Patients with Bipolar Disorder. Bipolar Disorders, 12, 657-666. https://doi.org/10.1111/j.1399-5618.2010.00854.x
[58] Yeh, Z. T., Tsai, M. C., Tsai, M. D., Lo, C. Y., & Wang, K. C. (2017). The Relationship between Theory of Mind and the Executive Functions: Evidence from Patients with Frontal Lobe Damage. Applied Neuropsychology. Adult, 24, 342. https://doi.org/10.1080/23279095.2016.1185425
[59] Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978). A Rating Scale for Mania: Reliability, Validity and Sensitivity. British Journal of Psychiatry the Journal of Mental Science, 133, 429-435. https://doi.org/10.1192/bjp.133.5.429
[60] Yucel, M. O., Devrimcizgven, H., Sakarya, A., Baskak, B., Zel Kizil, E. T., Sakarya, D., & Haran, S. (2016). The Relationship of Verbal Working Memory and Theory of Mind in First Degree Relatives of Patients with Schizophrenia and Bipolar Disorder. Turkish Journal of Psychiatry, 27, 1-6.