[1]
|
中华人民共和国国家卫生健康委员会医政医管局. 原发性肝癌诊疗规范(2019年版) [J]. 中华消化病与影像杂志(电子版), 2020, 10(1): 22-48.
|
[2]
|
Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660
|
[3]
|
ARC (2021) Latest Global Cancer Data: Cancer Burden Rises to 19.3 Mil-lion New Cases and 10.0 Million Cancer Deaths in 2020. https://gco.iarc.fr/today/data/factsheets/populations/160-china-fact-sheets
|
[4]
|
Allemani, C., Weir, H.K., Carreira, H., et al. (2015) Global Surveillance of Cancer Survival 1995-2009: Analysis of Individual Data for 25676887 Patients from 279 Population-Based Registries in 67 Countries (CONCORD-2). The Lancet, 385, 977-1010. https://doi.org/10.1016/S0140-6736(14)62038-9
|
[5]
|
Gerbes, A., Zoulim, F., Tilg, H., et al. (2018) Gut Roundtable Meeting Paper: Selected Recent Advances in Hepatocellular Carcinoma. Gut, 67, 380-388. https://doi.org/10.1136/gutjnl-2017-315068
|
[6]
|
Eso, Y. and Marusawa, H. (2018) Novel Approaches for Molec-ular Targeted Therapy against Hepatocellular Carcinoma. Hepatology Research, 48, 597-607. https://doi.org/10.1111/hepr.13181
|
[7]
|
Prasad, V., Kaestner, V. and Mailankody, S. (2018) Cancer Drugs Ap-proved Based on Biomarkers and Not Tumor Type-FDA Approval of Pembrolizumab for Mismatch Repair-Deficient Solid Cancers. JAMA Oncology, 4, 157-158.
https://doi.org/10.1001/jamaoncol.2017.4182
|
[8]
|
Qin, S., Ren, Z., Meng, Z., et al. (2020) Camrelizumab in Pa-tients with Previously Treated Advanced Hepatocellular Carcinoma: A Multicentre, Open-Label, Parallel-Group, Ran-domised, Phase 2 Trial. The Lancet Oncology, 21, 571-580.
https://doi.org/10.1016/S1470-2045(20)30011-5
|
[9]
|
Xing, P., Zhang, F., Wang, G., et al. (2019) Incidence Rates of Immune-Related Adverse Events and Their Correlation with Response in Advanced Solid Tumours Treated with NIVO or NIVO+IPI: A Systematic Review and Meta-Analysis. The Journal for ImmunoTherapy of Cancer, 7, Article No. 341. https://doi.org/10.1186/s40425-019-0779-6
|
[10]
|
Duffy, A.G., Ulahannan, S.V., Makorova-Rusher, O., et al. (2017) Tremelimumab in Combination with Ablation in Patients with Advanced Hepatocellular Carcinoma. Journal of Hepatology, 66, 545-551.
https://doi.org/10.1016/j.jhep.2016.10.029
|
[11]
|
Finn, R.S., Qin, S., Ikeda, M., et al. (2020) Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma. The New England Journal of Medicine, 382, 1894-1905. https://doi.org/10.1056/NEJMoa1915745
|
[12]
|
Ren, Z., Xu, J., Bai, Y., et al. (2021) Sintilimab plus a Bevacizumab Biosimilar (IBI305) versus Sorafenib in Unresectable Hepatocellular Carcinoma (ORIENT-32): A Randomised, Open-Label, Phase 2-3 Study. The Lancet Oncology, 22, 977-990. https://doi.org/10.1016/S1470-2045(21)00252-7
|
[13]
|
Shigeta, K., Datta, M., Hato, T., et al. (2020) Dual Pro-grammed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normali-zation and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma. Hepatology, 71, 1247-1261. https://doi.org/10.1002/hep.30889
|
[14]
|
Finn, R.S., Ikeda, M., Zhu, A.X., et al. (2020) Phase Ib Study of Len-vatinib plus Pembrolizumab in Patients with Unresectable Hepatocellular Carcinoma. Journal of Clinical Oncology, 38, 2960-2970.
https://doi.org/10.1200/JCO.20.00808
|
[15]
|
Xu, J., Shen, J., Gu, S., et al. (2021) Camrelizumab in Combination with Apatinib in Patients with Advanced Hepatocellular Carcinoma (RESCUE): A Nonrandomized, Open-Label, Phase II Trial. Clinical Cancer Research, 27, 1003-1011.
https://doi.org/10.1158/1078-0432.CCR-20-2571
|
[16]
|
Kudo, M., Finn, R.S., Qin, S., et al. (2018) Lenvatinib ver-sus Sorafenib in Firstline Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Randomised Phase 3 Non-Inferiority Trial. The Lancet, 391, 1163-1173.
https://doi.org/10.1016/S0140-6736(18)30207-1
|
[17]
|
Kelley, R.K., Sangro, B., Harris, W.P., et al. (2020) Efficacy, Tolerability, and Biologic Activity of a Novel Regimen of Tremelimumab (T) in Combination with Durvalumab (D) for Patients (pts) with Advanced Hepatocellular Carcinoma (aHCC). Journal of Clinical Oncology, 38, 4508-4508. https://doi.org/10.1200/JCO.2020.38.15_suppl.4508
|
[18]
|
Qin, S., Bai, Y., Lim, H.Y., et al. (2013) Randomized, Multicenter, Open-Label Study of Oxaliplatin plus Fluorouracil/Leucovorin versus Doxorubicin as Palliative Chemo-therapy in Patients with Advanced Hepatocellular Carcinoma from Asia. Journal of Clinical Oncology, 31, 3501-3508. https://doi.org/10.1200/JCO.2012.44.5643
|
[19]
|
Qin, S., Cheng, Y., Liang, J., et al. (2014) Efficacy and Safety of the FOLFOX4 Regimen versus Doxorubicin in Chinese Patients with Advanced Hepatocellular Carcinoma: A Subgroup Analysis of the EACH Study. Oncologist, 19, 1169-1178. https://doi.org/10.1634/theoncologist.2014-0190
|
[20]
|
Qin, S., Chen, Z., Liu, Y., et al. (2019) A Phase II Study of Anti-PD-1 Antibody Camrelizumab plus FOLFOX4 or GEMOX Systemic Chemotherapy as First-Line Therapy for Advanced Hepatocellular Carcinoma or Biliary Tract Cancer. Journal of Clinical Oncology, 37, 4074. https://doi.org/10.1200/JCO.2019.37.15_suppl.4074
|
[21]
|
Yu, L.X. and Schwabe, R.F. (2017) The Gut Microbi-ome and Liver Cancer: Mechanisms and Clinical Translation. Nature Reviews Gastroenterology & Hepatology, 14, 527-539. https://doi.org/10.1038/nrgastro.2017.72
|
[22]
|
Zhu, L., Baker, S.S., Gill, C., Liu, W., Alkhouri, R., Baker, R.D. and Gill, S.R. (2013) Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis (NASH) Patients: A Connection between Endogenous Alcohol and NASH. Hepatology, 57, 601-609. https://doi.org/10.1002/hep.26093
|
[23]
|
Chen, Y., Yang, F., Lu, H., Wang, B., Chen, Y., Lei, D., Wang, Y., Zhu, B. and Li, L. (2011) Characterization of Fecal Microbial Communities in Patients with Liver Cirrhosis. Hepatology, 54, 562-572. https://doi.org/10.1002/hep.24423
|
[24]
|
辛海荣, 李喜, 孙瑞芳, 等. 原发性肝癌患者内毒素与肠道菌群变化的相关性研究[J]. 中华普通外科杂志, 2019, 34(8): 686-688.
|
[25]
|
高艳颖, 向慧玲, 梁静, 韩涛, 张旭. 肠道菌群失衡在肝癌发生发展中的影响机制及益生菌对肝癌的预防作用[J]. 临床肝胆病杂志, 2022, 38(3): 699-702.
|
[26]
|
Zheng, Y., Wang, T., Tu, X., et al. (2019) Gut Microbiome Affects the Response to Anti-PD-1 Immuno-therapy in Patients with Hepatocellular Carcinoma. The Journal for ImmunoTherapy of Cancer, 7, Article No. 193.
https://doi.org/10.1186/s40425-019-0650-9
|
[27]
|
Routy, B., Le Chatelier, E., Derosa, L., et al. (2018) Gut Micro-biome Influences Efficacy of PD-1-Based Immunotherapy against Epithelial Tumors. Science, 359, 91-97. https://doi.org/10.1126/science.aan3706
|
[28]
|
Delaune, V., Orci, L.A., Lacotte, S., et al. (2018) Fecal Microbiota Transplantation: A Promising Strategy in Preventing the Progression of Non-Alcoholic Steatohepatitis and Improving the Anti-Cancer Immune Response. Expert Opinion on Biological Therapy, 18, 1061-1071. https://doi.org/10.1080/14712598.2018.1518424
|
[29]
|
Smits, L.P., Bouter, K.E.C., De Vos, W.M., et al. (2013) Therapeutic Potential of Fecal Microbiota Transplantation. Gastroenterology, 145, 946-953. https://doi.org/10.1053/j.gastro.2013.08.058
|
[30]
|
Spakowicz, D., Hoyd, R., Muniak, M., Husain, M., Bassett, J.S., Wang, L., et al. (2020) Inferring the Role of the Microbiome on Survival in Patients Treated with Immune Checkpoint Inhibitors: Causal Modeling, Timing, and Classes of Concomitant Medications. BMC Cancer, 20, Article No. 383. https://doi.org/10.1186/s12885-020-06882-6
|
[31]
|
Fessas, P., Naeem, M., Pinter, M., et al. (2021) Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma. Liver Cancer, 10, 583-592. https://doi.org/10.1159/000519108
|
[32]
|
Han, J.J., Zhang, S.Y., Xu, Y., et al. (2020) Beneficial Effect of Antibiotics and Microbial Metabolites on Expanded Vδ2Vγ9 T Cells in Hepatocellular Carcinoma Immunotherapy. Fron-tiers in Immunology, 11, Article No. 1380.
https://doi.org/10.3389/fimmu.2020.01380
|