影响醛固酮水平升高的相关因素研究进展
Research Progress on Related Factors Affecting Elevated Aldosterone Levels
DOI: 10.12677/ACM.2023.13122750, PDF,   
作者: 阿达莱提·麦提图尔荪：新疆医科大学研究生院，新疆 乌鲁木齐；李南方*：新疆维吾尔自治区人民医院高血压中心，新疆 乌鲁木齐
关键词: 醛固酮；肥胖；吸烟；饮酒；血脂；血糖；抑郁；焦虑；Aldosterone； Obesity； Smoking； Alcohol Consumption； Blood Lipids； Blood Sugar； Depression； Anxiety
摘要: 醛固酮是肾素–血管紧张素–醛固酮系统(RAAS)的一员，是参与调节水、电解质和血压稳态的主要盐皮质激素。醛固酮合成和分泌的调节主要受到促肾上腺皮质激素、循环钾浓度和血管紧张素II等刺激物的影响。近年来，大量研究已表明醛固酮作为体内的重要激素之一，醛固酮的过度分泌或调节失调在高血压、糖尿病、肥胖、肾病及心血管疾病的发生和发展中起重要作用。因此，早期认识醛固酮水平升高的相关因素及控制醛固酮水平可能是醛固酮介导的一系列疾病的预防和控制的一个环节。然而，醛固酮水平升高的影响或调节因素中，有些因素尚不够清楚或存在争议。在这篇综述中我们将总结影响醛固酮水平升高的相关因素。
Abstract: Aldosterone is a member of the renin-angiotensin-aldosterone system (RAAS) and is the major mineralocorticoid involved in the regulation of water, electrolytes and blood pressure homeostasis. The regulation of aldosterone synthesis and secretion is mainly influenced by stimulants such as corticotropin, circulating potassium concentrations, and angiotensin II. In recent years, a lot of studies have shown that aldosterone is one of the important hormones in the body, and the exces-sive secretion or dysregulation of aldosterone plays an important role in the occurrence and devel-opment of hypertension, diabetes, obesity, kidney disease and cardiovascular diseases. Therefore, an early understanding of the factors associated with elevated aldosterone levels and the control of aldosterone levels may be a link in the prevention and control of a range of aldosterone-mediated diseases. However, some of the effects or regulators of aldosterone levels are not clear enough or controversial. In this review, we will summarize the influencing factors and regulators of elevated aldosterone levels.
文章引用：阿达莱提·麦提图尔荪, 李南方. 影响醛固酮水平升高的相关因素研究进展[J]. 临床医学进展, 2023, 13(12): 19532-19540. https://doi.org/10.12677/ACM.2023.13122750

参考文献

[1] Laragh, J.H. and Sealey, J.E. (2011) The Plasma Renin Test Reveals the Contribution of Body Sodium-Volume Content (V) and Renin Angiotensin (R) Vasoconstriction to Long-Term Blood Pressure. American Journal of Hypertension, 24, 1164-1180. [Google Scholar] [CrossRef] [PubMed]
[2] Hattangady, N.G., Olala, L.O., Bollag, W.B., et al. (2012) Acute and Chronic Regulation of Aldosterone Production. Molecular and Cellular Endocrinology, 350, 151-162. [Google Scholar] [CrossRef] [PubMed]
[3] Sowers, J.R., Whaley-Connell, A. and Epstein, M. (2009) Narrative Review: The Emerging Clinical Implications of the Role of Aldosterone in the Metabolic Syndrome and Resistant Hyper-tension. Annals of Internal Medicine, 150, 776-783. [Google Scholar] [CrossRef] [PubMed]
[4] Sztechman, D., Czarzasta, K., Cud-noch-Jedrzejewska, A., Szczepanska-Sadowska, E. and Zera, T. (2018) Aldosterone and Mineralocorticoid Receptors in Regulation of the Cardiovascular System and Pathological Remodelling of the Heart and Arteries. Journal of Physiology and Pharmacology, 69, 829-845.
[5] Catena, C., Colussi, G. and Sechi, L.A. (2013) Aldosterone, Organ Damage and Dietary Salt. Clinical and Experimental Pharmacology and Physiology, 40, 922-928. [Google Scholar] [CrossRef] [PubMed]
[6] Gan, L., Li, N.F., Mulalibieke, H., et al. (2022) Higher Plasma Al-dosterone Is Associated with Increased Risk of Cardiovascular Events in Hypertensive Patients with Suspected OSA: UROSAH Data. Frontiers in Endocrinology (Lausanne), 13, Article ID: 1017177. [Google Scholar] [CrossRef] [PubMed]
[7] Tomaschitz, A., Pilz, S., Ritz, E., Meinitzer, A., Boehm, B.O. and Marz, W. (2010) Plasmaaldosterone Levels Are Associated with Increased Cardiovascular Mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. European Heart Journal, 31, 1237-1247. [Google Scholar] [CrossRef] [PubMed]
[8] Joseph, J.J., Echouffo-Tcheugui, J.B., Kalyani, R.R., Yeh, H.C., Bertoni, A.G., Effoe, V.S., et al. (2017) Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality among Af-rican Americans: The Jackson Heart Study. JACC: Heart Failure, 5, 642-651. [Google Scholar] [CrossRef] [PubMed]
[9] Briet, M. and Schiffrin, E.L. (2013) Vascular Actions of Aldoste-rone. Journal of Vascular Research, 50, 89-99. [Google Scholar] [CrossRef] [PubMed]
[10] Fiebeler, A., Muller, D.N., Shagdarsuren, E. and Luft, F.C. (2007) Aldos-terone, Mineralocorticoid Receptors, and Vascular Inflammation. Current Opinion in Nephrology and Hypertension, 16, 134-142. [Google Scholar] [CrossRef] 
[11] Blasi, E.R., Rocha, R., Rudolph, A.E., Blomme, E.A.G., Polly, M.L. and McMahon, E.G. (2003) Aldosterone/Salt Induces Renal Inflammation and Fibrosis in Hypertensive Rats. Kidney International, 63, 1791-1800. [Google Scholar] [CrossRef] [PubMed]
[12] Del Vecchio, L., Procaccio, M., Vigano, S. and Cusi, D. (2007) Mechanisms of Disease: The Role of Aldosterone in Kidney Damage and Clinical Benefits of Its Blockade. Na-ture Clinical Practice Nephrology, 3, 42-49. [Google Scholar] [CrossRef] [PubMed]
[13] Bauersachs, J., Jaisser, F. and Toto, R. (2015) Mineralocorticoid Recep-tor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases. Hypertension, 65, 257-263. [Google Scholar] [CrossRef] 
[14] Cosimato, C., Agoritsas, T. and Mavrakanas, T.A. (2021) Mineralocorticoid Receptor Antagonists in Patients with Chronic Kidney Disease. Pharmacology & Therapeutics, 219, Article ID: 107701. [Google Scholar] [CrossRef] [PubMed]
[15] Kesireddy, V., Tan, Y., Kline, D., Brock, G., Odei, J.B., Kluwe, B., Effoe, V.S., et al. (2019) The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients, 11, Article No. 955. [Google Scholar] [CrossRef] [PubMed]
[16] Emanuele, E., Geroldi, D., Minoretti, P., et al. (2005) Increased Plasma Aldosterone in Patients with Clinical Depression. Archives of Medical Research, 36, 544-548. [Google Scholar] [CrossRef] [PubMed]
[17] Kerstens, M.N., Kobold, A.C., Volmer, M., Koerts, J., Sluiter, W.J. and Dullaart, R.P. (2011) Reference Values for Aldosterone-Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium Consumption. Clinical Chemistry, 57, 1607-1611. [Google Scholar] [CrossRef] [PubMed]
[18] Nanba, K., Vaidya, A., Williams, G.H., et al. (2017) Age-Related Autonomous Aldosteronism. Circulation, 136, 347-355. [Google Scholar] [CrossRef] 
[19] Kathiresan, S., Larson, M.G., Benjamin, E.J., et al. (2005) Clinical and Genetic Correlates of Serum Aldosterone in the Community: The Framingham Heart Study. Ameri-can Journal of Hypertension, 18, 657-665. [Google Scholar] [CrossRef] [PubMed]
[20] Faulkner, J.L., Harwood, D., Kennard, S., et al. (2021) Die-tary Sodium Restriction Sex Specifically Impairs Endothelial Function via Mineralocorticoid Receptor-Dependent Reduc-tion in NO Bioavailability in Balb/C Mice. The American Journal of Physiology-Heart and Circulatory Physiology, 320, H211-H220. [Google Scholar] [CrossRef] [PubMed]
[21] Faulkner, J.L., Lluch, E., Kennard, S., et al. (2020) Selective De-letion of Endothelial Mineralocorticoid Receptor Protects from Vascular Dysfunction in Sodium-Restricted Female Mice. Biology of Sex Differences, 11, Article No. 64. [Google Scholar] [CrossRef] [PubMed]
[22] Caroccia, B., Seccia, T.M., Campos, A.G., Gioco, F., Kup-pusamy, M., Ceolotto, G., et al. (2014) GPER-1 and Estrogen Receptor-Beta Ligands Modulate Aldosterone Synthesis. Endocrinology, 155, 4296-4304. [Google Scholar] [CrossRef] [PubMed]
[23] Roger, V.L., Go, A.S., Lloyd-Jones, D.M., et al. (2012) Heart Disease and Stroke Statistics-2012 Update: A Report from the American Heart Association. Circulation, 125, e2-e220.
[24] Clark, B.A., Elahi, D. and Epstein, F.H. (1990) The Influence of Gender, Age, and the Menstrual Cycle on Plasma Atrial Natriuretic Peptide. The Journal of Clinical Endocrinology & Metabolism, 70, 349-352. [Google Scholar] [CrossRef] [PubMed]
[25] Kidambi, S., Kotchen, J.M., Grim, C.E., Raff, H., Mao, J., Singh, R.J. and Kotchen, T.A. (2007) Association of Adrenal Steroids with Hypertension and the Metabolic Syndrome in Blacks. Hypertension, 49, 704-711. [Google Scholar] [CrossRef] 
[26] Bochud, M., Nussberger, J., Bovet, P., Maillard, M.R., Elston, R.C., Paccaud, F., Shamlaye, C. and Burnier, M. (2006) Plasma Aldosterone Is Independently Associated with the Metabolic Syndrome. Hypertension, 48, 239-245. [Google Scholar] [CrossRef] 
[27] Matsubara, M., Maruoka, S. and Katayose, S. (2002) Inverse Relationship between Plasma Adiponectin and Leptinconcentrations in Normal-Weight and Obese Women. Eu-ropean Journal of Endocrinology, 147, 173-180. [Google Scholar] [CrossRef] [PubMed]
[28] Ghandehari, H., Le, V., Kamal-Bahl, S., Bassin, S.L. and Wong, N.D. (2009) Abdominal Obesity and the Spectrum of Global Cardiometabolic Risks in US Adults. International Journal of Obesity (London), 33, 239-248. [Google Scholar] [CrossRef] [PubMed]
[29] Briones, A.M., Nguyen Dinh Cat, A., Callera, G.E., Yogi, A., Burger, D., He, Y., et al. (2012) Adipocytes Produce Aldosterone through Calcineurin-Dependent Signaling Pathways: Implications in Diabetes Mellitus-Associated Obesity and Vascular Dysfunction. Hypertension, 59, 1069-1078. [Google Scholar] [CrossRef] 
[30] Ehrhart-Bornstein, M., Lamounier-Zepter, V., Schraven, A., et al. (2003) Human Adipocytes Secrete Mineralocorticoid-Releasing Factors. Proceedings of the National Academy of Sciences of the United States of America, 100, 14211- 14216. [Google Scholar] [CrossRef] [PubMed]
[31] Huby, A.-C., Antonova, G., Groenendyk, J., Gomez-Sanchez, C.E., Bollag, W.B., Filosa, J.A. and De Chantemèle, E.J.B. (2015) Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis. Circulation, 132, 2134-2145. [Google Scholar] [CrossRef] 
[32] Engeli, S., Bohnke, J., Gorzelniak, K., Janke, J., Schling, P., Bader, M., Luft, F.C., Sharma, A.M. and Bohnke, J. (2005) Weight Loss and the Ren-in-Angiotensin-Aldosterone System. Hypertension, 45, 356-362. [Google Scholar] [CrossRef] 
[33] Baer, L. and Radichevich, I. (1995) Cigarette Smoking in Hypertensive Patients Blood Pressure and Endocrine Responses. The American Journal of Medicine, 78, 564-568. [Google Scholar] [CrossRef] [PubMed]
[34] Laustiola, K.E., Lassila, R. and Nurmi, A.-K. (1988) Enhanced Activation of the Renin-Angiotensin-Aldosterone System in Chronic Cigarette Smokers: A Study of Monozygotic Twin Pairs Discordant for Smoking. Clinical Pharmacology & Therapeutics, 44, 426-430. [Google Scholar] [CrossRef] [PubMed]
[35] Delgado, G.E., Siekmeier, R., Krämer, B.K., Grübler, M.R., Tomaschitz, A., März, W. and Kleber, M.E. (2016) The Renin-Angiotensin-Aldosterone System in Smokers and Non-Smokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. In: Pokorski, M., Ed., Pulmonary Infection and Inflam-mation, Springer, Berlin, 75-82. [Google Scholar] [CrossRef] [PubMed]
[36] Saijonmaa, O., Nyman, T. and Fyhrquist, F. (2005) Regulation of An-giotensin-Converting Enzyme Production by Nicotine in Human Endothelial Cells. The American Journal of Physiolo-gy-Heart and Circulatory Physiology, 289, H2000- H2004. [Google Scholar] [CrossRef] [PubMed]
[37] Ljungberg, L.U. and Persson, K. (2008) Effect of Nicotine and Nicotine Metabolites on Angiotensin-Converting Enzyme in Human Endothelial Cells. Endothelium, 15, 239-245. [Google Scholar] [CrossRef] [PubMed]
[38] Toering, T.J., Gant, C.M., Visser, F.W., van der Graaf, A.M., Laverman, G.D., Jan Danser, A.H., Faas, M.M., Navis, G. and Lely, A.T. (2017) Gender Differences in Renin Angio-tensin Aldosterone System Affect Extra Cellular Volume in Healthy Subjects. American Journal of Physiology-Renal Physiology, 314, F873-F878. [Google Scholar] [CrossRef] [PubMed]
[39] Shukri, M.Z., Tan, J.W., Manosroi, W., Pojoga, L.H., Rivera, A., Williams, J.S., Seely, E.W., Adler, G.K., Jaffe, I.Z., Karas, R.H., et al. (2018) Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension, 71, 1083-1090. [Google Scholar] [CrossRef] 
[40] Sobrino, P., Ojeda, M.L., Nogales, F., et al. (2019) Binge Drinking Affects Kidney Function, Osmotic Balance, Aldosterone Levels, and Arterial Pressure in Ado-lescent Rats: The Potential Hypotensive Effect of Selenium Mediated by Improvements in Oxidative Balance. Hyperten-sion Research, 42, 1495-1506. [Google Scholar] [CrossRef] [PubMed]
[41] Aoun, E.G., Jimenez, V.A., Vendruscolo, L.F., et al. (2018) A Relationship between the Aldosterone-Mineralocorticoid Receptor Pathway and Alcohol Drinking: Preliminary Transla-tional Findings across Rats, Monkeys and Humans. Molecular Psychiatry, 23, 1466-1473. [Google Scholar] [CrossRef] [PubMed]
[42] Lékó András, H., McGinn, M.A. and Farokhnia, M. (2022) The Mineral-ocorticoid Receptor: An Emerging Pharmacotherapeutic Target for Alcohol Use Disorder? ACS Chemical Neuroscience, 13, 1832-1834. [Google Scholar] [CrossRef] [PubMed]
[43] Collier, S.R., Sandberg, K., Moody, A.M., Frechette, V., Cur-ry, C.D., Ji, H., Gowdar, R., Chaudhuri, D. and Meucci, M. (2015) Reduction of Plasma Aldosterone and Arterial Stiff-ness in Obese Pre- and Stage 1 Hypertensive Subjects after Aerobic Exercise. Journal of Human Hypertension, 29, 53-57. [Google Scholar] [CrossRef] [PubMed]
[44] Jones, J.M., Dowling, T.C., Park, J.-J., Phares, D.A., Park, J.-Y., Obisesan, T.O., Brown, M.D., Anderson, C.M.H. and Thwaites, D.T. (2007) Differential Aerobic Exercise-Induced Changes in Plasma Aldosterone between African Americans and Caucasians. Experimental Physiology, 92, 871-879. [Google Scholar] [CrossRef] [PubMed]
[45] Goessler, K., Polito, M. and Cornelissen, V.A. (2016) Effect of Exercise Training on the Renin-Angiotensin-Aldosterone System in Healthy Individuals: A Systematic Review and Meta-Analysis. Hypertension Research, 39, 119-126. [Google Scholar] [CrossRef] [PubMed]
[46] Carroll, J.F., Convertino, V.A., Wood, C.E., Greves, J.E., Lowenthel, D.T. and Pollock, M.L. (1995) Effect of Training on Blood Volume and Plasma Hormone Concentrations in the Elderly. Medicine & Science in Sports & Exercise, 27, 79-84. [Google Scholar] [CrossRef] 
[47] Waldman, B.M., Augustyniak, R.A., Chen, H. and Ros-si, N.F. (2017) Effects of Voluntary Exercise on Blood Pressure, Angiotensin II, Aldosterone, and Renal Function in Two-Kidney, One-Klip Hypertensive Rats. Integrated Blood Pressure Control, 10, 41-51. [Google Scholar] [CrossRef] 
[48] Lee, D.-C., Pate, R.R., Lavie, C.J., Sui, X., Church, T.S. and Blair, S.N. (2014) Leisure-Time Running Reduces All- Cause and Cardiovascular Mortality Risk. Journal of the American College of Cardiology, 64, 472-481. [Google Scholar] [CrossRef] [PubMed]
[49] Eckel, R.H., Jakicic, J.M., Ard, J.D., de Jesus, J.M., Houston Mil-ler, N., Hubbard, V.S., Lee, I.-M., et al. (2013) AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascu-lar Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guide-lines. Circulation, 129, S76-S99. [Google Scholar] [CrossRef] [PubMed]
[50] Pandey, A., Garg, S., Khunger, M., Darden, D., Ayers, C., Kumbhani, D.J., Mayo, H.G., de Lemos, J.A. and Berry, J.D. (2015) Dose-Response Relationship between Physical Activity and Risk of Heart Failure: A Meta-Analysis. Circulation, 132, 1786-1794. [Google Scholar] [CrossRef] 
[51] Bell, E.J., Lutsey, P.L., Windham, B.G. and Fol-som, A.R. (2013) Physical Activity and Cardiovascular Disease in African Americans in Atherosclerosis Risk in Com-munities. Medicine & Science in Sports & Exercise, 45, 901-907. [Google Scholar] [CrossRef] 
[52] Huan, Y., DeLoach, S., Keith, S.W., Goodfriend, T.L. and Falkner, B. (2012) Aldosterone and Aldosterone: Renin Ratio Associations with Insulin Resistance and Blood Pressure in African Americans. Journal of the American Society of Hypertension, 6, 56-65. [Google Scholar] [CrossRef] [PubMed]
[53] Saha, S., Graessler, J., Kopprasch, S. and Bornstein, S.R. (2012) Very-Low-Density Lipoprotein Mediates Transcriptional Regulation of Aldosterone Synthase in Human Adrenocortical Cells through Multiple Signaling Pathways. Cell and Tissue Research, 348, 71-80. [Google Scholar] [CrossRef] [PubMed]
[54] Xing, Y., Cohen, A., Rothblat, G., Sankaranarayanan, S., Weibel, G., Royer, L., Francone, O.L. and Rainey, W.E. (2011) Aldosterone Production in Human Adrenocortical Cells Is Stim-ulated by High-Density Lipoprotein 2 (HDL2) through Increased Expression of Aldosterone Synthase (CYP11B2). En-docrinology, 152, 751-763. [Google Scholar] [CrossRef] [PubMed]
[55] Baudrand, R., Pojoga, L.H., Vaidya, A., Garza, A.E., Vöhringer, P.A., Jeunemaitre, X., Hopkins, P.N., Yao, T.M., Williams, J., Adler, G.K., et al. (2015) Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects. Circulation, 132, 1825-1833. [Google Scholar] [CrossRef] 
[56] Joseph, J.J., Echouffo-Tcheugui, J.B., Kalyani, R.R., Yeh, H.-C., Bertoni, A.G., Effoe, V.S., Casanova, R., Sims, M., Correa, A., Wu, W.-C., et al. (2016) Aldosterone, Renin, and Diabetes Mellitus in African Americans: The Jackson Heart Study. The Journal of Clinical Endocrinology & Metabolism, 101, 1770-1778. [Google Scholar] [CrossRef] [PubMed]
[57] Corry, D.B. and Tuck, M.L. (2003) The Effect of Aldosterone on Glu-cose Metabolism. Hypertension Research, 5, 106-109. [Google Scholar] [CrossRef] [PubMed]
[58] Underwood, P.C. and Adler, G.K. (2013) The Renin Angiotensin Aldosterone System and Insulin Resistance in Humans. Current Hypertension Reports, 15, 59-70. [Google Scholar] [CrossRef] [PubMed]
[59] Guo, C., Ricchiuti, V., Lian, B.Q., Yao, T.M., Coutinho, P., Romero, J.R., Li, J., Williams, G.H. and Adler, J.K. (2008) Mineralocorticoid Receptor Blockade Reverses Obesi-ty-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines. Circulation, 7, 2253-2261. [Google Scholar] [CrossRef] 
[60] Ishii, M., Atarashi, K., Ikeda, T., Hirata, Y., Igari, T., Uehara, Y., et al. (1983) Role of the Aldosterone System in the Salt-Sensitivity of Patients with Benign Essential Hy-pertension. Japanese Heart Journal, 24, 79-90. [Google Scholar] [CrossRef] [PubMed]
[61] Kawarazaki, W. and Fujita, T. (2013) Aberrant Rac1-Mineralocorticoid Re-ceptor Pathways in Salt-Sensitive Hypertension. Clinical and Experimental Pharmacology and Physiology, 40, 929-936. [Google Scholar] [CrossRef] [PubMed]
[62] Barrett, P.Q., Bollag, W.B., Isales, C.M., McCarthy, R.T. and Ras-mussen, H. (1989) Role of Calcium in Angiotensin II-Mediated Aldosterone Secretion. Endocrine Reviews, 10, 1-22. [Google Scholar] [CrossRef] [PubMed]
[63] Ganguly, A. and Davis, J.S. (1994) Role of Calcium and Other Media-tors in Aldosterone Secretion from the Adrenal Glomerulosa Cells. Pharmacological Reviews, 46, 417-447.
[64] Capponi, A.M., Lew, P.D., Jornot, L. and Vallotton, M.B. (1984) Correlation between Cytosolic Free Ca2+ and Aldosterone Production in Bovine Adrenal Glomerulosa Cells. Evidence for a Difference in the Mode of Action of Angiotensin II and Potassium. Journal of Biological Chemistry, 259, 8863-8869. [Google Scholar] [CrossRef] 
[65] Hunyady, L., Baukal, A.J., Bor, M., Ely, J.A. and Catt, K.J. (1990) Regulation of 1,2-Diacylglycerol Production by Angiotensin-II in Bovine Adrenal Glomerulosa Cells. Endocri-nology, 126, 1001-1008. [Google Scholar] [CrossRef] [PubMed]
[66] Kojima, I., Kojima, K. and Rasmussen, H. (1985) Intracellular Cal-cium and Adenosine 3’,5’-Cyclic Monophosphate as Mediators of Potassium-Induced Aldosterone Secretion. Biochemi-cal Journal, 228, 69-76. [Google Scholar] [CrossRef] [PubMed]
[67] Häfner, S., Baumert, J., Emeny, R.T., et al. (2012) To Live Alone and to Be Depressed, an Alarming Combination for the Renin-Angiotensin-Aldosterone-System (RAAS). Psychoneuroendocri-nology, 37, 230-237. [Google Scholar] [CrossRef] [PubMed]
[68] Segeda, V., Izakova, L., Hlavacova, N., Bednarova, A. and Jezova, D. (2017) Aldosterone Concentrations in Saliva Reflect the Duration and Severity of Depressive Episode in a Sex Dependent Manner. Journal of Psychiatric Research, 91, 164-168. [Google Scholar] [CrossRef] [PubMed]
[69] Murck, H., Schlageter, L., Schneider, A., et al. (2020) The Potential Pathophysiological Role of Aldosterone and the Mineralocorticoid Receptor in Anxiety and Depres-sion—Lessons from Primary Aldosteronism. Journal of Psychiatric Research, 130, 82-88. [Google Scholar] [CrossRef] [PubMed]
[70] Hlavacova, N., Wes, P.D., Ondrejcakova, M., et al. (2012) Subchronic Treatment with Aldosterone Induces Depression-Like Behaviours and Gene Expression Changes Relevant to Major Depressive Disorder. International Journal of Neuropsychopharmacology, 15, 247-265. [Google Scholar] [CrossRef] 
[71] Hlavacova, N. and Jezova, D. (2008) Chronic Treatment with the Mineralocorticoid Hormone Aldosterone Results in Increased Anxiety-Like Behavior. Hormones and Behavior, 54, 90-97. [Google Scholar] [CrossRef] [PubMed]
[72] Bay-Richter, C., Hallberg, L., Ventorp, F., Janelidze, S. and Brundin, L. (2012) Aldosterone Synergizes with Peripheral Inflammation to Induce Brain IL-1beta Expression and Depressive-Like Effects. Cytokine, 60, 749-754. [Google Scholar] [CrossRef] [PubMed]

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