普洱茶调节apoE基因敲除小鼠血脂水平的研究

The Regulation of Pu-erh Tea onBlood Lipids in apoE-Gene Knocked Mice

摘要: 为了验证普洱茶对apoE基因敲除小鼠动脉粥样硬化的作用；本研究选取了40只4周龄雄性apoE基因敲除小鼠，按照体重随机分成降脂药组、模型组、生茶组、熟茶组4组外加10只正常对照组。用普洱茶汤进行干预性试验90天后，空腹12小时，摘眼球采血，采用全自动生化仪测血清中的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等血脂指标；试验结果显示：普洱茶(生、熟)均可显著控制小鼠体重增长(P < 0.05)；普洱生茶可显著降低小鼠血清中TG、LDL-C的含量，升高HDL-C的含量(P < 0.05)，可显著降低AI系数；因此可判定，普洱茶对apoE基因敲除小鼠的抗动脉粥样硬化有一定的调节作用。 This study aimed to investigate the effects of Pu-erh tea on blood lipids in apoE-knockout mice. So we selected 4-week-old male apoE-gene knocked mice, and they were randomly divided into four groups: atherosclerosis group, fermenting Pu-erh Tea group, fermented Pu-erh Tea group and drug group. The all mice were used as the control. All mice were fed with normal chow diet. After 90 days, Vessels blood was collected for serum lipid, using automatic biochemical analyzed measuring serum the total clesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and other hyperlipidemia indicators. The result is that Pu-erh Health (cooked) tea cansignificantly increase control of body weight (P < 0.05); reduce the high fat mice serum TG, LDL-C content, increased HDL-C in (P < 0.05); And cooked Pu-erh tea can significantly reduce the high fat rat serum TC, TG, LDL-C in (P < 0.05). These results suggested that Pu-erh tea may play a role in anti-atherosclerosis in apoE-knockout mice.