植物雌激素防治激素依赖性肿瘤研究进展

Research Progress on Prevention and Cure for Hormone-Dependent Neoplasm by Phytoestrogens

摘要: 探究植物雌激素防治激素依赖性肿瘤的文献发现：植物雌激素是来源于植物的杂环多酚类天然化合物，包括黄酮类、木脂素类、香豆素类、二苯乙烯类、醌类、三萜类、甾醇类、真菌雌激素类等。其雌激素活性较雌二醇低，有雌激素或抗雌激素双向调节作用，对激素相关性疾病具有广泛防治作用。实验与临床研究显示：植物雌激素对乳腺癌、卵巢癌、子宫内膜癌、前列腺癌(包括良性前列腺增生)、结肠癌等激素依赖性肿瘤有防治作用。其机制为直接参与机体的内分泌调节、抗氧化、抑制肿瘤血管新生、抑制肿瘤转移、抑制癌基因表达、促进抑癌基因表达、诱导肿瘤细胞凋亡、抑制肿瘤生长与增殖等。含植物雌激素的中药很多，植物雌激素防治激素依赖性肿瘤应用前景广阔。 Through exploring literatures about prevention and cure for hormone-dependent neoplasm by phytoestrogens we found that: Phytoestrogens are plant-derived polyphenolic natural heterocyclic compounds including flavones, lignans, coumarins, stilbenes, quinones, triterpenoids, sterols, mycoestrogen and so on. Phytoestrogens have both estrogenic and anti-estrogenic activity, with a two-way regulation ability and extensive preventive and therapeutic effects on hormone-related diseases. Experimental and clinical studies have shown that phytoestrogens can prevent and treat hormone-dependent neoplasms such as breast cancer, ovarian cancer, endometrial cancer, prostate cancer (including benign prostatic hyperplasia), colon cancer and so forth. Its anti-tumor mechanisms are: directly involving in the body’s endocrine regulation, anti-oxidizing, inhibiting tumor angiogenesis and metastasis, repressing oncogene expression, promoting anti-oncogene expression, inducing tumor cell apoptosis, inhibiting tumor growth and proliferation and so on. There are many Chinese materia medica containing phytoestrogens, which are promising chemoprevention and treatment for hormone-dependent neoplasms.