传统中药片剂——四物片的表面张力测定

Determine the Surface Tension of Chinese Herbal Tablet—Siwu Tablet

摘要:

目的：薄膜包衣技术会出现裂片等情况，这影响包衣片的外观，更重要是会影响薄膜的均匀性，从而影响包衣片活性物质的释放。因此需要一种能够反映片剂包衣质量的参数。研究表明，片剂的表面张力对薄膜与片芯之间的粘附性有重要的影响。本文主要通过Zisman外推法测定中药片——四物片的表面张力。方法：通过测定一系列测定液在片芯表面的接触角，采用Zisman外推法得到片芯的表面参数—表面张力。结果：测得四物片芯的表面张力为70 dyne/cm3。结论：四物片具有高表面能、亲水性强及双极性的特性，Zisman外推法能够准确测定中药片剂的表面张力。

Abstract: Objective: Lobes problem could encounter by film coating technology, which will affect the appearance of the coated tablets and, most importantly, will affect the uniformity of the film-coated tablets and the release of the active materials. Therefore, a parameter which could represent the quality of the tablet coating is needed. Research shows that the surface tension is an essential factor to the adhesion between the film and the tablet core. The study investigated the surface energy characteristics of Siwu tablet. The surface free energy of tablet core was measured by Zisman critical surface tension method. Method: After measuring the contact angle of a series of pure liquid on the surface of the core by contact angle instrument, the surface tension of Siwu tablets was determined by Zisman critical surface tension method. Result: Surface tension of Siwu tablet core was about 70 dyne/cm3. Conclusion: Siwu tablet is a high surface energy and hydrophilicity substance and has the bipolar characteristics. This study also indicates that the Zisman critical surface tension method could accurately measure and calculate the surface tension of solid.