玛咖分散片的处方工艺研究

Formulation and Quality Investigation of Maca Dispersible Tablets

摘要: 本研究制备了玛咖分散片并考察其处方工艺和质量，分别以崩解时限、可压性和分散均匀性为指标因素，选择适宜的崩解剂、稀释剂、黏合剂、润滑剂；以崩解时限为指标，以正交设计法确定最佳处方，并进行处方工艺优化和制剂稳定性考察，考察根据处方制成的分散片的质量符合中国药典要求，玛咖分散片的处方工艺成熟稳定、可控性好，分散性好。

Abstract: Maca dispersible tablet was prepared in this study. The paper explored its formulation and quality. Factor investigation was performed by using disintegration time, compressibility and dispersion uniformity as indices in order to choose suitable disintegrant, diluents, binder and lubricants. The best formulation was optimized by using the orthogonal design method which took the disintegration time as an index. The quality of the dispersible tablets meets Chinese Pharmacopoeia 2010 criteria. The formulation of Maca dispersible tablet technology is mature, stable, easily controllable and has good disintegration.