不同剂量枯草杆菌二联活菌颗粒治疗轮状病毒性肠炎效果评价

Evaluation of Effect of the Treatment to Rotavirus Enteritis with Different Dose Medilac-Vita

摘要: 目的：评估不同剂量枯草杆菌二联活菌颗粒治疗轮状病毒性肠炎的临床效果。方法：选择240例轮状病毒性肠炎患儿随机分成大剂量组(120例)和小剂量组(120例)。两组予补液，口服消旋卡多曲颗粒。小剂量组加服枯草杆菌二联活菌颗粒<1岁，每次0.5 g，1~2岁每次1 g，2次/d；大剂量组加服枯草杆菌二联活菌颗粒<1岁，每次1 g，1~2岁每次2 g，2次/d。疗程3~7 d。比较两组临床效果。结果：大剂量组和小剂量组临床显效率(79.17% vs 60.00%)、总有效率(99.17% vs 89.17%)比较差异有统计学意义；治疗3 d后日均大便分别(1.31 ± 0.66)次、(1.62 ± 0.88)次(t = 3.087, P = 0.002)，腹泻平均持续时间分别(2.89 ± 1.16) d、(3.43 ± 1.14) d (t = 3.637, P= 0.000)。结论：大剂量枯草杆菌二联活菌颗粒治疗轮状病毒性肠炎可显著提高疗效，减少大便次数，缩短腹泻持续时间，具有较高的临床应用价值。

Abstract: Objective: To evaluate the efficacy of different dose medilac-vita in treatment of children with ro-tavirus enteritis. Methods: 240 cases were randomly divided into low dose group with 120 cases and high dose group with 120 cases. Both groups were treated with complement fluid, racecadotril and different dose medilac-vita (low dose group: under 1 year old 0.5 g, 1 - 2 years old 1 g, 2 times a day; high dose group: under 1 year old 1 g, 1 - 2 years old 2 g, 2 times a day). All the treatments lasted for 3 - 7 days. The clinical efficacy of both groups was observed. Results: The high dose group’s total effective rate was 99.17% and control group’s was 89.17%. And there was also a statistic difference in curative rate (79.17% vs 60.00%). On the 4th day, the patients in the high dose group passed (1.31 ± 0.66) stools/day versus (1.62 ± 0.88) stools/day in the low dose group (t = 3.087, P = 0. 002). The mean diarrhea duration was (2.89 ± 1.16) days in the high dose group and (3.43 ± 1.14) days in the low dose group (t = 3.637, P = 0.000). Conclusions: The high dose me-dilac-vita can improve the remarkable effective rate in children with rotavirus enteritis, reduce stool frequency and decrease the duration of diarrhea; it is worthy of application.