ERK5信号通路研究现状
Review of the ERK5 Signaling Pathway Research
DOI: 10.12677/WJCR.2014.44008, PDF, HTML, 下载: 3,015  浏览: 17,490  科研立项经费支持
作者: 罗 松, 苏胜发, 欧阳伟炜, 卢 冰：贵阳医学院肿瘤学教研室，贵阳
关键词: ERK5；信号通路；MAPK；ERK5； Signaling Pathways； MAPK
摘要: 细胞外信号调节激酶5(extracellular signal regulated kinase, ERK5)是丝裂原活化蛋白激酶(mitogen activated protein kinase, MAPK)系统中的重要组成部分，也是MAPK信号转导通路中较新的一条通路，近几年备受人们关注。它可以被各种刺激因素激活，对细胞生存、增殖和分化有着重要作用，与血管发育、增殖等功能密切相关。本文从ERK5的来历、结构、性质、特点以及与肿瘤和非肿瘤疾病的关系，并对它以后的研究方向进行综述。
Abstract: Extracellular signal regulated kinase 5 (ERK5) is an important part of mitogen activated protein kinase (MAPK) system, and also is a new signal transduction pathway of MAPK signaling system, which has attracted much attention in recent years. ERK5 can be activated by many stimulating factors and plays an important role in cell survival, proliferation and differentiation. Furthermore, ERK5 is closely related to vascular development and proliferation, and other critical functions. This paper focuses on the origin, structure, property, physiological features of ERK5, and the relation-ship between ERK5 and tumor and non-oncologic diseases, and reviews the research direction in the future.
文章引用：罗松, 苏胜发, 欧阳伟炜, 卢冰. ERK5信号通路研究现状[J]. 世界肿瘤研究, 2014, 4(4): 41-46. http://dx.doi.org/10.12677/WJCR.2014.44008

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