长期被误诊的2例乳房外Paget病

Two Case Report of Extramammary Paget’s Disease Being Long-Term Misdiagnosed

摘要: 乳房外Paget病是一种罕见的，起源于顶泌汗腺导管开口的恶性肿瘤。表现为有顶泌汗腺部位的皮肤边界清楚的慢性浸润性红色斑块，多发生于外生殖器、腋窝、肚脐等部位，红斑瘙痒是最常见的症状，也可以出现糜烂、渗出、结痂等，临床表现的多样性，导致会经常出现误诊，在一定程度上耽误治疗。本文介绍了2例被误诊的乳房外Paget病，分析了相关的原因。

Abstract: Extramammary Paget’s disease (EMPD) is a rare cutaneous adenocarcinoma and usually originates from the duct openings of apocrine sweat glands. The disease appears as a well-defined chronically infiltrated plaque in the skin with apocrine sweat glands. The genitalia, armpits and navel are most commonly affected. While pruritic erythematous plaque is the most common symptom, erosion, oozing, crusting could also be observed. The diversity of the clinical manifestations sometimes leads to misdiagnosis, even delayed treatment. Two cases of misdiagnosed EMPD and the possible reasons for the misdiagnosis are discussed in this article.