花色苷对非酒精性脂肪肝脂质代谢调控机制的研究进展
The Regulation Mechanisms of Anthocyanins on Lipid Metabolism in Non-Alcoholic Fatty Liver
DOI: 10.12677/HJFNS.2015.44016, PDF, HTML, XML, 下载: 2,610  浏览: 10,579 
作者: 周方行, 张莉珂, 杨 燕:中山大学公共卫生学院营养学系,广东 广州
关键词: 花色苷非酒精性脂肪肝脂代谢Anthocyanins Non-Alcoholic Fatty Liver Disease Lipid Metabolism
摘要: 花色苷是一类具有多种生物活性的黄酮类化合物,它能够对多种疾病起到防治作用,其中包括非酒精性脂肪肝等慢性非传染性疾病。花色苷对非酒精性脂肪肝的脂代谢的调节作用,在该疾病的预防、诊断以及治疗等过程中均起到重要作用,其相关的作用机制更是近年来的研究热点。因此,本文就花色苷对非酒精性脂肪肝脂类代谢中的研究进展进行综述,并提出了今后的研究展望。
Abstract: Anthocyanins are types of biological activity of flavonoids compounds. They can contribute to a va-riety of diseases’ prevention and treatment, including NAFLD and other chronic non-communicable diseases. The effects of anthocyanins through the regulation of lipid metabolism play important roles in prevention, treatment and related aspects in NAFLD. Therefore, we summarized the current research progress on anthocyanins of lipid metabolism in non-alcoholic fatty liver disease, as well as future research perspectives.
文章引用:周方行, 张莉珂, 杨燕. 花色苷对非酒精性脂肪肝脂质代谢调控机制的研究进展[J]. 食品与营养科学, 2015, 4(4): 116-122. http://dx.doi.org/10.12677/HJFNS.2015.44016

参考文献

[1] Konczak, I. and Zhang, W. (2004) Anthocyanins-More than Nature’s Colours. Journal of Biomedicine and Biotech-nology, 2004, 239-240.
http://dx.doi.org/10.1155/S1110724304407013
[2] Nabavi, S.F., Habtemariam, S., Daglia, M., Shafighi, N., Barber, A.J. and Nabavi, S.M. (2015) Anthocyanins as a Potential Therapy for Diabetic Retinopathy. Current Medicinal Chemistry, 22, 51-58.
http://dx.doi.org/10.2174/0929867321666140815123852
[3] Valenti, L., Riso, P., Mazzocchi, A., Porrini, M., Fargion, S. and Agostoni, C. (2013) Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity, 2013, Article ID: 145421.
http://dx.doi.org/10.1155/2013/145421
[4] Del, R.D., Borges, G. and Crozier, A. (2010) Berry Flavonoids and Phenolics: Bioavailability and Evidence of Protective Effects. British Journal of Nutrition, 104, S67-S90.
http://dx.doi.org/10.1017/S0007114510003958
[5] Vlachojannis, C., Zimmermann, B.F. and Chruba-sik-Hausmann, S. (2015) Efficacy and Safety of Pomegranate Medicinal Products for Cancer. Evidence-Based Com-plementary and Alternative Medicine, 2015, Article ID: 258598.
http://dx.doi.org/10.1155/2015/258598
[6] Ahmed, M. (2015) Non-Alcoholic Fatty Liver Disease in 2015. World Journal of Hepatology, 7, 1450-1459.
http://dx.doi.org/10.4254/wjh.v7.i11.1450
[7] Arguello, G., Balboa, E., Arrese, M. and Zanlungo, S. (2015) Recent Insights on the Role of Cholesterol in Non- Alcoholic Fatty Liver Disease. Biochimica et Biophysica Acta, 1852, 1765-1778.
http://dx.doi.org/10.1016/j.bbadis.2015.05.015
[8] Altinbas, A., Sowa, J. P., Hasenberg, T. and Canbay, A. (2015) The Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease. Minerva gastroenterologica e dietologica, 61, 159-169.
[9] Abd, E.S. and El-Den, A.E. (2015) Non-Alcoholic Fatty Liver Disease: The Diagnosis and Management. World Journal of Hepatology, 7, 846-858.
http://dx.doi.org/10.4254/wjh.v7.i6.846
[10] Yilmaz, B., Sahin, K., Bilen, H., Bahcecioglu, I.H., Bilir, B., Ashraf, S., Halazun, K.J. and Kucuk, O. (2015) Carotenoids and Non-Alcoholic Fatty Liver Disease. Hepatobiliary Surgery and Nutrition, 4, 161-171.
[11] Jiang, X., Tang, X., Zhang, P., Liu, G. and Guo, H. (2014) Cyanidin-3-O-β-Glucoside Protects Primary Mouse Hepatocytes against High Glucose-Induced Apoptosis by Modulating Mitochondrial Dysfunction and the PI3K/Akt Pathway. Biochemical Pharmacology, 90, 135-144.
http://dx.doi.org/10.1016/j.bcp.2014.04.018
[12] Zhang, P.W., Chen, F.X., Li, D., Ling, W.H. and Guo, H.H. (2015) A CONSORT-Compliant, Randomized, Double- Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients with Nonalcoholic Fatty Liver Disease. Medicine (Baltimore), 94, e758.
http://dx.doi.org/10.1097/md.0000000000000758
[13] Tang, X., Shen, T., Jiang, X., Xia, M., Sun, X., Guo, H. and Ling, W. (2015) Purified Anthocyanins from Bilberry and Black Currant Attenuate Hepatic Mitochondrial Dys-function and Steatohepatitis in Mice with Methionine and Choline Deficiency. Journal of Agricultural and Food Che-mistry, 63, 552-561.
http://dx.doi.org/10.1021/jf504926n
[14] Li, D., Wang, P., Luo, Y., Zhao, M. and Chen, F. (2015) Health Benefits of Anthocyanins and Molecular Mechanisms: Update from Recent Decade. Critical Reviews in Food Science and Nutrition, Epub Ahead of Print.
[15] Morrison, M.C., Liang, W., Mulder, P., Verschuren, L., Pie-terman, E., Toet, K., Heeringa, P., Wielinga, P.Y., Kooistra, T. and Kleemann, R. (2015) Mirtoselect, an Anthocya-nin-Rich Bilberry Extract, Attenuates Non-Alcoholic Steatohepatitis and Associated Fibrosis in ApoE*3Leiden Mice. Journal of Hepatology, 62, 1180-1186.
http://dx.doi.org/10.1016/j.jhep.2014.12.011
[16] Chang, J.J., Hsu, M.J., Huang, H.P., Chung, D.J., Chang, Y.C. and Wang, C.J. (2013) Mulberry Anthocyanins Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipo-genesis and Promotion of Hepatic Lipid Clearance. Journal of Agricultural and Food Chemistry, 61, 6069-6076.
http://dx.doi.org/10.1021/jf401171k
[17] Lee, B., Lee, M., Lefevre, M. and Kim, H.R. (2014) Anthocyanins Inhibit Lipogenesis during Adipocyte Differentiation of 3T3-L1 Preadipocytes. Plant Foods for Human Nutrition, 69, 137-141.
http://dx.doi.org/10.1007/s11130-014-0407-z
[18] Tsuda, T., Horio, F., Uchida, K., Aoki, H. and Osawa, T. (2003) Dietary Cyanidin 3-O-β-D-Glucoside-Rich Purple Corn Color Prevents Obesity and Ameliorates Hyperglycemia in Mice. Journal of Nutrition, 133, 2125-2130.
[19] Vendrame, S., Daugherty, A., Kristo, A.S. and Klimis-Zacas, D. (2014) Wild Blueberry (Vaccinium angustifolium)- Enriched Diet Improves Dyslipidaemia and Modulates the Expression of Genes Related to Lipid Metabolism in Obese Zucker Rats. British Journal of Nutrition, 111, 194-200.
http://dx.doi.org/10.1017/S0007114513002390
[20] Tang, C.C., Huang, H.P., Lee, Y.J., Tang, Y.H. and Wang, C.J. (2013) Hepatoprotective Effect of Mulberry Water Extracts on Ethanol-Induced Liver Injury via Anti-Inflammation and Inhibition of Lipogenesis in C57BL/6J Mice. Food and Chemical Toxicology, 62, 786-796.
http://dx.doi.org/10.1016/j.fct.2013.10.011
[21] Salamone, F., Li, V.G., Titta, L., Puzzo, L., Barbagallo, I., La Delia, F., Zelber-Sagi, S., Malaguarnera, M., Pelicci, P.G., Giorgio, M. and Galvano, F. (2012) Moro Orange Juice Prevents Fatty Liver in Mice. World Journal of Gastroenterology, 18, 3862-3868.
http://dx.doi.org/10.3748/wjg.v18.i29.3862
[22] Villalpando-Arteaga, E.V., Mendieta-Condado, E., Esquivel-Solis, H., Canales-Aguirre, A.A., Galvez-Gastelum, F.J., Mateos-Diaz, J.C., Rodriguez-Gonzalez, J.A. and Marquez-Aguirre, A.L. (2013) Hibiscus sabdariffa L. Aqueous Extract Attenuates Hepatic Steatosis through Down-Regulation of PPAR-Gamma and SREBP-1c in Diet-Induced Obese Mice. Food & Function, 4, 618-626.
http://dx.doi.org/10.1039/c3fo30270a
[23] Seymour, E.M., Tanone, I.I., Urcuyo-Llanes, D.E., Lewis, S.K., Kira-kosyan, A., Kondoleon, M.G., Kaufman, P.B. and Bolling, S.F. (2011) Blueberry Intake Alters Skeletal Muscle and Adipose Tissue Peroxisome Proliferator-Activated Receptor Activity and Reduces Insulin Resistance in Obese Rats. Journal of Medicinal Food, 14, 1511-1518.
http://dx.doi.org/10.1089/jmf.2010.0292
[24] Guo, H., Liu, G., Zhong, R., Wang, Y., Wang, D. and Xia, M. (2012) Cyanidin-3-O-β-Glucoside Regulates Fatty Acid Metabolism via an AMP-Activated Protein Kinase-Dependent Signaling Pathway in Human HepG2 Cells. Lipids in Health and Disease, 11, 10.
http://dx.doi.org/10.1186/1476-511X-11-10
[25] Guo, H., Li, D., Ling, W., Feng, X. and Xia, M. (2011) Antho-cyanin Inhibits High Glucose-Induced Hepatic mtGPAT1 Activation and Prevents Fatty Acid Synthesis through PKC. The Journal of Lipid Research, 52, 908-922.
http://dx.doi.org/10.1194/jlr.M013375
[26] Vauzour, D., Tejera, N., O’Neill, C., Booz, V., Jude, B., Wolf, I.M., Rigby, N., Silvan, J.M., Curtis, P.J., Cassidy, A., de Pascual-Teresa, S., Rimbach, G. and Minihane, A.M. (2015) An-thocyanins Do Not Influence Long-Chain N-3 Fatty Acid Status: Studies in Cells, Rodents and Humans. Journal of Nutritional Biochemistry, 26, 211-218.
http://dx.doi.org/10.1016/j.jnutbio.2014.09.005
[27] Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A. and Milenkovic, D. (2012) Bilberry Anthocyanin-Rich Extract Alters Expression of Genes Related to Atherosclerosis Development in Aorta of Apo E-Deficient Mice. Nutrition, Metabolism and Cardiovascular Diseases, 22, 72-80.
http://dx.doi.org/10.1016/j.numecd.2010.04.011
[28] Farrell, N., Norris, G., Lee, S.G., Chun, O.K. and Blesso, C.N. (2015) Anthocyanin-Rich Black Elderberry Extract Improves Markers of HDL Function and Reduces Aortic Cholesterol in Hyperlipidemic Mice. Food & Function, 6, 1278- 1287.
http://dx.doi.org/10.1039/C4FO01036A
[29] Wang, D., Xia, M., Gao, S., Li, D., Zhang, Y., Jin, T. and Ling, W. (2012) Cyanidin-3-O-β-Glucoside Upregulates Hepatic Cholesterol 7α-Hydroxylase Expression and Reduces Hyper-cholesterolemia in Mice. Molecular Nutrition & Food Research, 56, 610-621.
http://dx.doi.org/10.1002/mnfr.201100659
[30] Zhu, Y., Huang, X., Zhang, Y., Wang, Y., Liu, Y., Sun, R. and Xia, M. (2014) Anthocyanin Supplementation Improves HDL-Associated Paraoxonase 1 Activity and Enhances Cho-lesterol Efflux Capacity in Subjects with Hypercholesterolemia. Journal of Clinical Endocrinology & Metabolism, 99, 561-569.
http://dx.doi.org/10.1210/jc.2013-2845
[31] Chang, H.C., Peng, C.H., Yeh, D.M., Kao, E.S. and Wang, C.J. (2014) Hibiscus sabdariffa Extract Inhibits Obesity and Fat Accumulation, and Improves Liver Steatosis in Humans. Food & Function, 5, 734-739.
http://dx.doi.org/10.1039/c3fo60495k
[32] Liang, Y., Chen, J., Zuo, Y., Ma, K.Y., Jiang, Y., Huang, Y. and Chen, Z.Y. (2013) Blueberry Anthocyanins at Doses of 0.5 and 1 % Lowered Plasma Cholesterol by Increasing Fecal Excretion of Acidic and Neutral Sterols in Hamsters Fed a Cholesterol-Enriched diet. European Journal of Nutrition, 52, 869-875.
http://dx.doi.org/10.1007/s00394-012-0393-6
[33] Batista, Â.G., Lenquiste, S.A., Cazarin, C.B.B., Da Silva, J.K., Luiz-Ferreira, A., Bogusz, S., Wang Hantao, L., de Souza, R.N., Augusto, F., Prado, M.A. and Maróstica, M.R. (2014) Intake of Jaboticaba Peel Attenuates Oxidative Stress in Tissues and Reduces Circulating Saturated Lipids of Rats with High-Fat Diet-Induced Obesity. Journal of Functional Foods, 6, 450-461.
http://dx.doi.org/10.1016/j.jff.2013.11.011
[34] Kyu-Ho Hana, S.K.K.S. (2013) Purple Pota to Flake Reduces Serum Lipid Profile in Rats Fed a Cholesterol-Rich Diet. Journal of Functional Foods, 5, 974-980.
http://dx.doi.org/10.1016/j.jff.2013.01.007
[35] Shih, P.H., Hwang, S.L., Yeh, C.T. and Yen, G.C. (2012) Syner-gistic Effect of Cyanidin and PPAR Agonist against Nonalcoholic Steatohepatitis-Mediated Oxidative Stress-Induced Cytotoxicity through MAPK and Nrf2 Transduction Pathways. Journal of Agricultural and Food Chemistry, 60, 2924-2933.
http://dx.doi.org/10.1021/jf300005v
[36] Cheng, D.M., Pogrebnyak, N., Kuhn, P., Poulev, A., Wa-terman, C., Rojas-Silva, P., Johnson, W.D. and Raskin, I. (2014) Polyphenol-Rich Rutgers Scarlet Lettuce Improves Glucose Metabolism and Liver Lipid Accumulation in Diet- Induced Obese C57BL/6 Mice. Nutrition, 30, S52-S58.
http://dx.doi.org/10.1016/j.nut.2014.02.022
[37] Brader, L., Overgaard, A., Christensen, L.P., Jeppesen, P.B. and Hermansen, K. (2013) Polyphenol-Rich Bilberry Ameliorates Total Cholesterol and LDL-Cholesterol When Implemented in the Diet of Zucker Diabetic Fatty Rats. The Review of Diabetic Studies, 10, 270-282.
http://dx.doi.org/10.1900/RDS.2013.10.270
[38] Jakobsdottir, G., Nilsson, U., Blanco, N., Sterner, O. and Nyman, M. (2014) Effects of Soluble and Insoluble Fractions from Bilberries, Black Currants, and Raspberries on Short-Chain Fatty Acid Formation, Anthocyanin Excretion, and Cholesterol in Rats. Journal of Agricultural and Food Chemistry, 62, 4359-4368.
http://dx.doi.org/10.1021/jf5007566
[39] de Pascual-Teresa, S. (2014) Molecular Mechanisms Involved in the Cardiovascular and Neuroprotective Effects of Anthocyanins. Archives of Biochemistry and Biophysics, 559, 68-74.
http://dx.doi.org/10.1016/j.abb.2014.04.012
[40] Wright, O.R., Netzel, G.A. and Sakzewski, A.R. (2013) A Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Dried Purple Carrot on Body Mass, Lipids, Blood Pressure, Body Composition, and Inflammatory Markers in Overweight and Obese Adults: The QUENCH Trial. Canadian Journal of Physiology and Pharmacology, 91, 480-488.
http://dx.doi.org/10.1139/cjpp-2012-0349