摘要:
目的：探讨血浆脑钠肽(BNP)水平与脑出血患者预后的关系。方法：回顾性分析2010年12月~2013年12月治疗的109例脑出血患者，根据转归分为转归良好组和转归不良组。采用酶联免疫吸附法(ELISA)测定血浆BNP。结果：患者卒中病史、吸烟史、血肿体积、格拉斯哥昏迷评分、美国国立卫生研究量卒中量表评分、血肿是否破入脑室及血浆脑钠肽水平均与转归结果有密切关系(X2 = 3.678, 7.096, t = 2.962, 2.361, 3.806, X2 = 4.687, t = 4.962, P < 0.05); Logistic回归分析发现血浆脑钠肽水平与急性脑出血患者的预后相关(P = 0.032, OR = 1.789, 95% CI 1.052~3.043)。结论：血浆BNP是脑出血患者转归的危险因素之一，对患者预后的判断有一定的价值。
Abstract:
Objective: To study brain natriuretic peptide (BNP) levels and prognosis in patients with cerebral hemorrhage. Methods: Retrospective analysis of 109 cases with cerebral hemorrhage from December 2010 to December 2014 for the treatment was divided into 2 groups, according to the outcome of a good outcome group and poor outcome groups. The enzyme-linked immunosorbent assay (ELISA) was used for determination of plasma BNP. Result: There was a close relationship between patient outcomes and a previous history of stroke, smoking history, hematoma volume, Glasgow Coma Scale score, National Research Health Stroke Scale score, rupture of hematoma into the ventricle, plasma brain natriuretic peptide level. (X2 = 3.678, 7.096, t = 2.962, 2.361, 3.806, X2 = 4.687, t = 4.962, P < 0.05); Logistic regression analysis revealed a correlation between the prognosis of brain natriuretic peptide levels in patients with acute cerebral hemorrhage (P = 0.032, OR = 1.789, 95% CI 1.052 - 3.043). Conclusions: Plasma brain natriuretic peptide level is an independent risk factor for patients with cerebral hemorrhage and may be a useful prognostic factor for these patients.