S-泮托拉唑的研究进展
Recent Progress in Preparation of S-Pantoprazole
DOI: 10.12677/JOCR.2015.34018, PDF, HTML, XML, 下载: 2,300  浏览: 7,622  科研立项经费支持
作者: 王 婷, 曾银凤, 朱 槿, 黄晴菲, 王启卫：中国科学院成都有机化学研究所，四川 成都；彭丽君, 王红丹：常州化学研究所，江苏 常州
关键词: 泮托拉唑；手性拆分；不对称氧化；Pantoprazole； Chiral Resolution； Asymmetric Oxidation
摘要: 泮托拉唑是一种抑制胃酸分泌的质子泵抑制剂。临床研究表明，与消旋体及其对映体相比，S-泮托拉唑抑酸效果好，生物利用度高，毒副作用低。目前报道的制备S-泮托拉唑的方法主要是手性拆分和不对称氧化。本文简要概述了S-泮托拉唑的制备研究状况。
Abstract: Pantoprazole is one of the blockbuster gastric proton pump inhibitors (PPIs). The clinical study showed that S-pantoprazole provides better acid control, higher bio-availability and lower side effects compared to the racemic pantoprazole and R-panto-prazole. It is reported that the optical pure S-pantoprazole could be prepared by chiral resolution and catalytic asymmetric oxidation. This review briefly described the deve-lopment of the preparation method for the optically pure S- pantoprazole.
文章引用：王婷, 曾银凤, 彭丽君, 王红丹, 朱槿, 黄晴菲, 王启卫. S-泮托拉唑的研究进展[J]. 有机化学研究, 2015, 3(4): 139-146. http://dx.doi.org/10.12677/JOCR.2015.34018

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