NF-КBP65和BCL-2蛋白在多形性腺瘤中的表达

The Expression of NF-КBP65 and BCL-2 Protein in Pleomorphic Adenoma

摘要: 目的：检测NF-КBP65与BCL-2蛋白在多形性腺瘤及瘤旁正常涎腺组织中的表达情况，探讨NF-КBP65与BCL-2蛋白在多形性腺瘤的表达意义。方法：采用免疫组织化学S-P法检测20例涎腺多形性腺瘤组织石蜡标本中NF-КBP65与BCL-2蛋白表达水平，以瘤旁正常涎腺组织作为对照，进行组内及组间比较。结果：多形性腺瘤和瘤旁正常涎腺组织中NF-КBP65表达的阳性率分别为55%和10.0%，差异有统计学意义(P<0.05)；BCL-2表达的阳性率分别为35%和10.0%，差异有统计学意义(P<0.05)。结论： NF-КBP65 和BCL-2的协同作用可能对多形性腺瘤的发生、发展起重要作用。

Abstract: Objective: To detect the expression and discuss the expression meaning of NF-КBP65 and BCL-2 protein in pleomorphic adenoma. Methods: The expression of NF-КBP65 and BCL-2 protein in pa-raffin embedded specimens of pleomorphic adenoma and adjacent normal salivary gland tissue of 20 cases was detected using immunohistochemical S-P method. Results: The positive rates of NF-КBP65 expression in pleomorphic adenoma and adjacent normal salivary gland tissue were  55% and 10%, and the positive rates of BCL-2 expression were 35% and 10% respectively. The differences of NF-КBP65 and BCL-2 expression in pleomorphic adenoma and tumor adjacent normal salivary gland tissue were statistically significant (P < 0.05). Conclusion: NF-КBP65 and BCL-2 may play an important role in pleomorphic adenoma occurrence and development.