银促进的α-氨基芳乙酮与NH4PF6的缩合环化反应：2-芳甲酰基咪唑衍生物的合成研究
Silver-Promoted Cyclization of α-Aminoacetophenone with NH4PF6: Synthesis of 2-Arylformylimidazole Derivatives
DOI: 10.12677/JOCR.2016.41002, PDF, HTML, XML, 下载: 2,464  浏览: 8,446 
作者: 王祚辉, 程晓雪, 王 浩, 凌心茹, 赵晨晨, 胡茂林：温州大学化学与材料工程学院，浙江 温州
关键词: α-氨基芳乙酮；咪唑；缩合反应；环化反应；氧化脱胺；α-Aminoacetophenone； Imidazole； Condensation； Cyclization； Oxidative Deamination
摘要: 本文发展了一种由六氟磷酸铵提供铵源，与两分子α-氨基芳乙酮在醋酸银的氧化作用下，经过缩合、脱胺、环化等串联反应合成2-芳甲酰基咪唑衍生物的新方法。在最优条件下，合成了8种2-芳甲酰基咪唑衍生物，收率为52%~93%。所有的产物结构通过IR、NMR和MS等手段表征。该方法具有原料简单易得、操作简便等优点。
Abstract: A new method for AgOAc-oxidative cyclization of α-aminoacetophenones with NH4PF6 leading to 2-arylformylimidazoles derivatives has been developed. Under the optimal reaction conditions, a wide range of 2-arylformylimidazoles derivatives were synthesized in moderate to good yields ranging from 52% to 93%. These products were confirmed by IR, NMR and MS. The results show that this method has advantages such as the availability for raw materials and simple chemical operations.
文章引用：王祚辉, 程晓雪, 王浩, 凌心茹, 赵晨晨, 胡茂林. 银促进的α-氨基芳乙酮与NH4PF6的缩合环化反应：2-芳甲酰基咪唑衍生物的合成研究[J]. 有机化学研究, 2016, 4(1): 6-12. http://dx.doi.org/10.12677/JOCR.2016.41002

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