非小细胞肺癌免疫治疗研究进展

Advances in Immune Therapy for Non Small Cell Lung Cancer

摘要: 目前肺癌已成为所有癌症中发病人数最多的疾病，其死亡率逐年呈上升趋势。近年来，虽然以化疗为主的综合疗法使非小细胞肺癌患者的生存率有所提高，但是患者总体5年生存率较低，并且由于放化疗的附加损害，患者的生活质量和实际生存率并未显著改变。近几年随着肿瘤免疫学及分子生物学研究的进一步深入与完善，肺癌的免疫治疗得到广泛关注，并为非小细胞肺癌患者的治疗提供了新的方向。本文对当前非小细胞肺癌免疫治疗的研究概况进行综述。

Abstract: At present, lung cancer has become the leading cause of death in various types of cancer, the inci-dence and mortality rate is rising. In recent years, although non small cell lung cancer patients survival rate prolongs the combination therapy with chemotherapy, patients and the overall 5- year survival rate is very low, and due to the additional damage of radiotherapy and chemotherapy, the patient’s quality of life and the actual survival rate did not significantly change. In recent years, with the further development and improvement of tumor immunology and molecular biology, immune therapy of lung cancer has been widely concerned, and provides a new direction for the treatment of non-small cell lung cancer patients. This review summarizes the current research progress in the treatment of non small cell lung cancer.