摘要:
目的：探讨NLR评价结直肠癌不同分期预后的价值，为结直肠癌患者开展个体化治疗、延长生存期提供理论依据。方法：统计符合要求的结直肠癌患者，依据ROC曲线取得NLR = 2.54值为本课题的研究截点,并分为低、高NLR两组，比较两组患者在临床特征及预后生存期的差异。结果：单因素分析证实：低、高NLR组在除年龄外的其他基本特征间差异无统计学意义(P < 0.05)；在临床特征（治疗前白细胞计数、TNM分期）方面比较差异有统计学意义(P < 0.05)；治疗前低NLR组与高NLR组患者的1、3年生存率、总生存期(OS)、3年无进展生存期(PFS)差异均有统计学意义(P < 0.05)。多因素分析证实：NLR和TNM分期方法分别是结直肠癌的独立危险预后因素。结论：NLR与结直肠癌相关预后因素中的年龄、治疗前白细胞计数、TNM分期相关。
Abstract:
Objective: The study investigates NLR to evaluate at different stages prognosis of colorectal cancer, then provides individualized treatment and prolong survival theoretical basis for colorectal cancer patients. Methods: Add up all colorectal cancer patients who meet the requirements, and choose NLR = 2.54 as study intercept according to the ROC curve. All the patients were divided into low NLR and high NLR groups, then clinical features and prognosis of survival of the two groups would be compared. Results: Univariate analysis showed that: There was no significant difference in the basic features besides age between low NLR and high NLR groups (P < 0.05). There was statistically significant difference in clinical features (white blood cell count before treatment, TNM staging) between the two groups (P < 0.05). There were statistically significant differences in 1- and 3-year survival rate, overall survival (OS) and 3-year progression-free survival (PFS) between the two groups (P < 0.05). Multivariate analysis confirmed: NLR and TNM staging were independent risk factors for colorectal cancer prognosis. Conclusion: NLR is correlated with age, the white blood cell count before treatment and TNM staging in prognostic factors of colorectal cancer.