FGF21对慢性–急性酒精性肝损伤的保护作用
The Protection of FGF21 on Chronic-Binge Alcohol-Induced Liver Injury
DOI: 10.12677/OJNS.2016.44055, PDF, HTML, XML, 下载: 1,807  浏览: 4,185  科研立项经费支持
作者: 许韵宇, 艾为明, 林 虹, 刘彦隆：温州医科大学，浙江 温州；左 伟, 谢龙腾, 邱国仕, 蒋永生：宁波市第四医院，浙江 象山
关键词: 酒精肝；成纤维细胞生长因子21；Alcoholic Liver Disease； Fibroblast Growth Factor 21
摘要: 本文探讨成纤维细胞生长因子21(FGF21)对慢性–急性酒精性肝损伤的保护作用。酒精处理组用慢性–急性酒精处理诱导小鼠肝损伤模型，FGF21保护组在喂酒精饮食的同时每天注射FGF21 (1 mg/kg)。12天后检测各组小鼠肝脏甘油三脂的含量以及外周血中ALT,AST,甘油三脂，游离脂肪酸和甘油的含量。结果发现FGF21可以显著抑制酒精诱导的肝脏脂肪堆积和肝损伤。表明FGF21对慢–急性酒精诱导的肝脏损伤有保护作用。
Abstract: The aim is to investigate the role of FGF21 on chronic-binge alcohol-induced liver injury. Alcohol treatment group was made by chronic-binge alcohol treatment on mice and FGF21 treatment group was made by above alcohol treatment and FGF21 (1 mg/kg) injection daily. Liver triglyceride and plasma ALT, AST, triglyceride, FFA and glycerol were measured 12 days later. Results showed that FGF21 significantly inhibited alcohol-induced fat accumulation and liver injury, which indicated that FGF21 played a protection role on chronic-binge alcohol-induced liver injury.
文章引用：许韵宇, 左伟, 谢龙腾, 邱国仕, 蒋永生, 艾为明, 林虹, 刘彦隆. FGF21对慢性–急性酒精性肝损伤的保护作用[J]. 自然科学, 2016, 4(4): 447-451. http://dx.doi.org/10.12677/OJNS.2016.44055

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