基于层次分析模型的晚期非小细胞肺癌个体化治疗

Individualized Treatment of Advanced Non-Small Cell Lung Cancer Based on Analytic Hierarchy Process

摘要: 本文针对晚期非小细胞肺癌，用层次分析法这一著名的综合评价数学模型给出了个体化治疗方案。首先我们编制了面向病人的包含疗效性、安全性，耐受性、缓解时间以及经济性这5个指标的相对重要性比较问卷。接着通过统计分析10位非小细胞胃癌治疗领域的专家反馈回的专家打分表，综合确定出了手术、化疗、放疗、靶向治疗和免疫治疗这5种治疗方案相对于疗效性、安全性，耐受性、缓解时间以及经济性的相对重要性得分表。在此基础上，我们应用层次分析的专业软件yaahp分析“个体化”的病人，得到了手术、化疗、放疗、靶向治疗和免疫治疗这5种治疗方案的重要性排序，实现了晚期非小细胞肺癌的个体化治疗。

Abstract: In this paper, the individualized treatment plan of advanced non-small cell lung cancer (NSCLC) is given by using AHP, which is the well-known comprehensive evaluation mathematical model. Firstly, we developed a patient-oriented and relative importance comparison questionnaire with the following five indicators: efficacy, safety, tolerability, response time and economic performance. Then, we made a statistical analysis about the scoring sheets which were feedback from 10 experts in the non-small cell gastric cancer field. The five kinds of treatments, including surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy, were compared and evaluated by the curative effect, safety, tolerance, remission period and the economy, and the relative importance score tables about these qualities are obtained. Based on these, we use the professional software yaahp of analytic hierarchy process to analyze the “individualized” patients, and we obtain the importance ranking of the five treatments, including surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy. And the individualized treatment of later period non-small cell lung cancer is come true.