超声加速下2-苯基咪唑啉的高效合成

Rapid and Efficient Synthesis of 2-Phenyl Imidazolines under Ultrasonic Acceleration

摘要: 目的：快速高效且温和地合成2-苯基咪唑啉衍生物。方法：苯甲醛及取代苯甲醛为反应底物，和乙二胺在NBS的催化下，以超声合成各类2-苯基咪唑啉。结果：以二氯甲烷15毫升为反应溶剂，超声条件为25 min，反应结束直接过滤即得产物，产率为78.1%~99%。结论：该方法可以迅速温和地制备该类小分子化合物。

Abstract: Objective: To synthesize 2-phenylimidazoline derivatives rapidly and efficiently. Methods: Ben-zaldehyde and substituted benzaldehydes were used as the reaction substrate, and ethylenedia-mine was used as the catalyst to synthesize 2-phenylimidazolines by ultrasound. Results: 15 ml dichloromethane as the reaction solvent, reaction under ultrasonic conditions for 25 min, after the termination of the reaction directly filtered product, the yield was 78.1% - 99%. Conclusion: This method can rapidly and mildly prepare such small molecular compounds.