冬凌草甲素抗乳腺癌作用的研究进展

Review on the Effects of Anti-Breast Cancer by Oridonin

摘要: 乳腺癌的发病率居于全世界女性恶性肿瘤之首。目前，我国乳腺癌病人以3%的速度逐年递增，且呈现低龄化趋势。西医治疗乳腺癌主要采取的手术、放疗和化疗方式虽见效快，但副作用也比较显著。中医中药作为中华国粹，近年来在肿瘤综合治疗方面具有重要影响，其以安全、有效且副作用小等优势，在弥补西医治疗的缺点和不足、以及预防和阻断肿瘤的发生发展中，有重要的疗效和独特的优势。但长期以来，中医药在乳腺癌综合治疗中的地位不高，因此，探讨中药在乳腺癌综合治疗中的切入点和时机，以及中医药预防乳腺癌的机理，具有较为深远的意义。本文以冬凌草甲素为切入，总结概括近10年来冬凌草甲素在治疗及预防乳腺癌中取得的进展，为进一步探究冬凌草在乳腺癌治疗方面的相关机制提供临床参考及基础依据。

Abstract: The incidence of breast cancer ranked the first female malignancy in the world. At present, breast cancer patients increase at a rate of 3% annually, and it appears to be even younger. The main ways to treat breast cancer in western medicine are operation, radiotherapy and chemotherapy, which are effective speedily, but show obvious side effects. As the quintessence of China, Chinese medicine have an important influence on cancer treatment, which are safe and effective and have few side effects, which play a great effective and distinctive role in making up for the shortcoming and deficiency of Chinese and western medicine treatment and preventing and blocking cancer development. Since Chinese medicine have not been in high position in breast cancer treatment for a long time, it is very important to work for the breakthrough point and time of Chinese medicine in breast cancer treatment and mechanism of Chinese medicine in preventing breast cancer. This article is based on oridonin which summarize the development in curing and preventing breast cancer in almost 10 years, which builds the foundation for better research and provides clinic evidence.