香砂脘痛胶囊质量研究
Quality Standard of Xiangshawantong Capsule
DOI: 10.12677/PI.2017.62005, PDF, HTML, XML, 下载: 1,478  浏览: 3,849 
作者: 辛振杰*：罗定市中医院，广东 罗定；饶秋红：广州中医药大学第一临床医学院，广东 广州
关键词: 香砂脘痛胶囊；质量；薄层色谱；高效液相色谱法；Xiangshawantong Capsule； Quality； TLC； HPLC
摘要: 目的：探讨建立控制香砂脘痛胶囊质量的方法。方法：采用薄层色谱法(TLC)对川芎、当归和赤芍药材进行定性鉴别，采用高效液相色谱法(HPLC)对牡荆苷进行含量测定。结果：TLC特征斑点明显清晰、专属性强。牡荆苷在0.0576~0.2880 μg (r = 0.9998)间具有良好的线性关系，平均回收率分别为99.73% (RSD = 1.5%, n = 6)。结论：所建标准适用于香砂脘痛胶囊的质量控制。
Abstract: Objective: To establish the quality standard Xiangshawantong Capsule. Methods: Thin-Layer chro- matography (TLC) was employed for the qualitative determination of Chuanxiong Rhizoma, Angelicae Sinensis Radix and Paeoniae Radix Rubra High performance liquid chromatography (HPLC) was applied for the determination of Vitexin in Xiangshawantong Capsule. Results: The characteristic by TLC was obvious and highly specific. The Linear range of Vitexin ranged from 0.0576 - 0.2880 μg (r = 0.9998). The average recovery was 99.73% (RSD = 2.1%, n = 6) respectively. Conclusion: The established standard can be used for the quality control of Xiangshawantong Capsule.
文章引用：辛振杰, 饶秋红. 香砂脘痛胶囊质量研究[J]. 药物资讯, 2017, 6(2): 25-30. https://doi.org/10.12677/PI.2017.62005

参考文献

[1] 国家药典委员会. 中华人民共和国药典[M]. 北京: 化学工业出版社, 2015.
[2] 孙琳, 黄松, 赖小平. HPLC法测定不同产地及品种木豆叶中牡荆苷的含量[J]. 中药材, 2011, 34(1): 31-32.
[3] 罗海燕, 李庆国, 关世侠, 等. 关节乐胶囊质量研究[J]. 今日药学, 2010, 20(12): 15-18.
[4] 李功营, 唐红梅, 丘振文. 岭南常用中药木豆叶中牡荆苷的HPLC含量测定[J]. 中药新药与临床药理, 2007, 18(6): 474-476.
[5] 高东藩, 杨胜华. 赤芍及几种中成药中赤芍的薄层层析鉴别[J]. 华西药学杂志, 1992, 7(4): 213-215.
[6] 孔菲, 丁莹, 梁雪, 等. 川芎、当归的薄层层析鉴别[J]. 中医药学报, 2013, 41(2): 56-57.