Br∅nsted酸性离子液体催化吲哚与α，β-不饱和酮的Michael加成反应
The Michael Addition Reaction of Indoles and α, β-Unsaturated Ketones Catalyzed by Br∅nsted Acidic Ionic Liquid
DOI: 10.12677/JOCR.2017.52011, PDF, HTML, XML, 下载: 1,872  浏览: 4,550  国家自然科学基金支持
作者: 马雪成, 刘秀梅, 刘晨江：石油天然气精细化工教育部&自治区重点实验室，新疆大学理化测试中心，新疆 乌鲁木齐
关键词: 离子液体；催化；吲哚；α； β-不饱和酮；Michael加成；Ionic Liquid； Catalysis； Indole； α； β-Unsaturated Ketone； Michael Addition
摘要: 本文以Brønsted酸性离子液体[ThiN(CH2)4SO3][p-CH3PhSO3]催化吲哚与α，β-不饱和酮发生Michael加成反应，得到了一系列β-吲哚酮化合物，最高产率可达99%。离子液体催化剂循环使用3次以上，催化活性没有明显下降。该方法具有条件温和、操作简单的特点，为β-吲哚酮化合物的合成提供了一种新的方法。
Abstract: The Michael addition reaction of indoles with α, β-unsaturated ketones was studied using brønsted acidic ionic liquid [ThiN(CH2)4SO3][p-CH3PhSO3] as catalyst. A series of β-indolone derivatives were obtained in up to 99% yield. The catalyst ionic liquid used in the approach can be easily recycled and reused for at least three cycles without decreasing its catalytic activity. The approach is characterized by mild condition and simple operation. It provides a new method for the synthesis of β-indole derivatives.
文章引用：马雪成, 刘秀梅, 刘晨江. Br∅nsted酸性离子液体催化吲哚与α，β-不饱和酮的Michael加成反应[J]. 有机化学研究, 2017, 5(2): 86-93. https://doi.org/10.12677/JOCR.2017.52011

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