熟地平颤颗粒结合重复经颅磁刺激治疗帕金森氏病的临床研究
Clinical Study on Treatment of Parkinson’s Disease with Shudi Pingchan Granule Combined with Repetitive Transcranial Magnetic Stimulation
DOI: 10.12677/TCM.2017.62011, PDF, HTML, XML, 下载: 1,591  浏览: 4,001  国家自然科学基金支持
作者: 叶 青, 袁晓蕾, 张 艳, 袁灿兴：上海中医药大学附属龙华医院脑病科，上海
关键词: 熟地平颤颗粒；重复经颅磁刺激；帕金森氏病；运动障碍；非运动症状；Shudi Pingchan Granule； Repetitive Transcranial Magnetic Stimulation； Parkinson’s Disease； Dyskinesia； Non-Motor Symptoms
摘要: 目的：观察熟地平颤颗粒结合重复经颅磁刺激在改善帕金森病运动障碍及非运动症状方面的优势。方法：将76例帕金森病患者随机分为治疗组(38例)在西药常规基础上给予熟地平颤颗粒联合高频重复经颅磁刺激治疗(rTMS)、对照组(38例)给予西药常规治疗，疗程共12周。采用UPDRS II、III量表评分，自主神经症状量表(SCOPA-AUT)、帕金森病睡眠量表(PDSS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、简易智能精神状态量表(MMSE)、帕金森病睡眠量表(PDSS)、帕金森病生存质量问卷(PDQ-39)评价临床疗效。结果：(1) 在运动障碍评分及运动并发症方面：对照组、治疗组各阶段UPDRS II评分与治疗前比较无明显差异。治疗组在治疗后的第8周与第12周UPDRSⅢ评分明显低于同期对照组(P < 0.01)。(2) 在非运动症状方面：对照组、治疗组各阶段MMSE评分无明显差异，同期两组间比较无明显差异；治疗组至第12周HAMA、HAMD、SCOPA-AUT、PDQ39评分均明显低于对照组，PDSS评分高于对照组(P < 0.05)。两组均未见明显不良反应。结论：熟地平颤颗粒结合高频rTMS对帕金森病运动障碍及非运动症状均有效果且安全性佳。
Abstract: Objective: To observe the advantages of Shudi Pingchan granule combined with repetitive tran-scranial magnetic stimulation in improving motor dysfunction and non-motor symptoms of Par-kinson’s disease. Method: 76 cases of Parkinson disease were randomly divided into control group (38 cases) received the routine treatment of Western medicine and treatment group (38 cases) received Shudi Pingchan granule combined with high frequency repetitive transcranial magnetic stimulation (rTMS) on the basis of control group; the treatment lasted for 12 weeks, using UPDRS II and III score, autonomic symptoms scale (SCOPA-AUT), Parkinson’s disease Sleep Scale (PDSS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini Mental State Scale (MMSE), Parkinson’s disease Sleep Scale (PDSS), the quality of the survival questionnaire to evaluate Parkinson’s disease (PDQ-39) clinical efficacy. Result: (1) There were no significant differences in UPDRS scores between the control group and the treatment group before and after treatment. The UPDRS score of the treatment group was significantly lower than that of the control group (P < 0.01) at eighth and twelfth weeks after treatment. (2) Scores in non-motor symptoms: there is no significant difference before and after treatment between the treatment group and control group in each stage of the MMSE score, compared no significant difference between the two groups; for the treatment group to 12th weeks, HAMA, HAMD, SCOPA-AUT, PDQ39 scores were significantly lower than the control group, PDSS score higher than the control group (P < 0.05). There were no obvious adverse reactions in the two groups. Conclusion: Shudi Pingchan granule combined with rTMS had good effects and securities for improving dyskinesia and non-motor symptoms of Parkinson’s disease.
文章引用：叶青, 袁晓蕾, 张艳, 袁灿兴. 熟地平颤颗粒结合重复经颅磁刺激治疗帕金森氏病的临床研究[J]. 中医学, 2017, 6(2): 60-67. https://doi.org/10.12677/TCM.2017.62011

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