有氧运动训练对去卵巢大鼠IGF-1、BMP-2、p38表达的影响
The Effects of Different Load Exercise on the Expression of IGF-1, BMP-2 and p38 in Serum of Ovariectomized Rats
DOI: 10.12677/HJBM.2017.73010, PDF, HTML, XML, 下载: 1,513  浏览: 3,348  科研立项经费支持
作者: 崔雪莲, 朱秋子, 张心辉, 李 进, 刘红玉, 钟卫权*：徐州医科大学医学技术学院，江苏 徐州
关键词: 运动训练；去卵巢大鼠；IGF-1；BMP-2；P38；Exercise； Ovariectomized Rats； IGF-1； BMP-2； p38 MAPK
摘要: 目的：运动疗法作为一种康复治疗的手段，对运动系统和心血管系统的慢性疾病有一定疗效。本研究通过不同强度有氧运动对去卵巢大鼠血清中IGF-1、BMP-2和P38水平的变化，探讨运动对去卵巢大鼠骨代谢的影响。方法：大鼠随机分为假手术组、骨质疏松模型组、30 min运动组和60 min运动组。除了假手术组大鼠，其他几组大鼠去除卵巢。运动组大鼠去除卵巢后一周进行训练，每周6次，共8周。结果：8周训练后，骨质疏松模型组和30 min运动组大鼠体重与假手术组比较显著增加(P < 0.05)，大运动负荷没有影响。与假手术组相比，骨质疏松模型组大鼠的BMP-2的表达有明显降低(P < 0.01)，IGF-1和P38降低(P < 0.05)。60 min运动组的BMP-2、P38和IGF-1的水平与去卵巢大鼠组比较，有显著升高(P < 0.01)。结论：60 min跑台运动对去卵巢所致大鼠骨质疏松症有一定的防治作用。
Abstract: Objective: Exercise is useful to some chronic disease of sports system and cardiovascular system. The research was to explore the effect of exercise on osteoporosis by detecting the BMP-2, P38 and Insulin Growth Factor-1 (IGF-1). Methods: Female SD rats were randomly divided into sham-op- erated group, OVX group, 30 min exercise group, and 60 min exercise group. Rats in OVX group and two exercise groups were ovariectomized. Sham-operated group was not removed. After one week of surgery, exercise group started moderate intensity exercise, six days a week for 8 weeks. Results: After 8 weeks, compared with the control group, the weight of model group increased significantly (P < 0.05). The expression of BMP-2 decreased much significantly (P < 0.01) and the p38 and IGF-1 decreased apparently (P < 0.01). But BMP-2, p38 and IGF-1 in 60 min exercise group increased much significantly (P < 0.01) compared with that of OVX group’s. Conclusion: 60min treadmill running could be benefit to the osteoporosis in ovariectomized rats.
文章引用：崔雪莲, 朱秋子, 张心辉, 李进, 刘红玉, 钟卫权. 有氧运动训练对去卵巢大鼠IGF-1、BMP-2、p38表达的影响[J]. 生物医学, 2017, 7(3): 59-63. https://doi.org/10.12677/HJBM.2017.73010

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