自体富集骨髓干细胞复合人工骨材料在脊柱融合中的应用评价
The Application Evaluation of Enriched Bone Marrow Mesenchymal Stem Cells Combined with Arificial Bone for Spine Fusion
DOI: 10.12677/MS.2017.75071, PDF, HTML, XML, 下载: 1,541  浏览: 5,056  国家自然科学基金支持
作者: 廖 羽, 曾怡乐, 杨 明, 谢欣蓉, 程丽佳:成都大学医学院,四川 成都
关键词: 骨髓干细胞脊柱融合术磷酸钙羟基磷灰石Bone Marrow Stem Cells Spinal Fusion Calcium Phosphate Hydroxyapatite
摘要: 对现有高水平的论文进行整合,评价富集骨髓干细胞技术结合生物复合材料在脊柱融合中的疗效,为进一步的研究提供思路和参考。依次检索Pubmed、ScienceDerict、CNKI三个数据库中关于富集骨髓干细胞技术结合生物复合材料脊柱融合的文章,选择相关度最高的文章进行评价。结论得出富集骨髓干细胞技术结合生物复合材料在脊柱融合中有利于成骨,并且具有较好的可行性和安全性,将为未来的研究提供一定意义上的指导。
Abstract: Through the integration of the existing high level paper, to evaluate the therapeutic effect of en-riched bone marrow stem cell technology and biocomposites in spinal fusion, and to provide ideas and references for further study. The articles about enriched bone marrow stem cell technology and biocomposites in spinal fusion in the three databases of Pubmed, ScienceDerict, and CNKI have been retrieved, and the articles with the highest relevance have been selected to evaluate. Conclusion: The combination of bone marrow stem cell technology and biocomposites in spinal fusion is beneficial to osteosynthesis, and it is feasible and safe. It will provide some guidance for future research.
文章引用:廖羽, 曾怡乐, 杨明, 谢欣蓉, 程丽佳. 自体富集骨髓干细胞复合人工骨材料在脊柱融合中的应用评价[J]. 材料科学, 2017, 7(5): 536-541. https://doi.org/10.12677/MS.2017.75071

参考文献

[1] 闫伟, 杨莉, 凌梅, 等. 自体骨髓富集间质干细胞与羟基磷灰石磷酸三钙材料复合在脊柱融合中的应用[J]. 中国组织工程研究, 2016, 20(8): 1075-1080.
[2] 王永明, 王峰, 邵婷, 等. MSCs复合双相磷酸钙陶瓷促进腰椎骨折患者脊柱融合[J]. 现代生物医学进展, 2015, 33(15): 6484-6582.
[3] 王健, 邱勇, 夏春林, 等. 富集自体骨髓间质干细胞复合羟基磷灰石/磷酸三钙植骨材料在脊柱融合中的应用[J].中国组织工程研究与临床康复, 2007(11): 5536-5539.
[4] 张蒲, 干耀恺, 唐坚, 等. 干细胞技术结合新型可降解材料进行腰椎融合的临床研究[J]. 中外骨科杂志, 2008 46(7), 493-496.
[5] 陈海峰, 王健. 富集骨髓干细胞复合人工骨在椎体后路融合中的临床应用[J]. 临床骨科杂志, 2009, 12(3): 259-261.
[6] 张蒲, 干耀恺, 唐坚, 等. 富集骨髓干细胞结合β磷酸三钙在脊柱融合的临床应用[J]. 临床骨科杂志, 2006, 9(1): 1-3.
[7] Gan, Y., Dai, K., Zhang, P., et al. (2008) The Clinical Use of Enriched Bone Marrow Stem Cells Combined with Porous Beta-Tricalcium Phosphate in Posterior Spinal Fusion. Biomaterials, 29, 3973-3982.
[8] Nancy, E. and Epstein, M.D. (2008) An Analysis of Non-Instrumented Posterolateral Lumbar Fusions Performed in Predominantly Geriatric Patients Using Lamina Autograft and Beta Tricalcium Phosphate. The Spine Journal, 29, 3973-3982.
[9] Thaler, M., Lechner, R., Gstottner, M., et al. (2013) The Use of Beta-Tricalcium Phosphate and Bone Marrow Aspirateas a Bone Graft Substitute in Posterior Lumbar Interbody Fusion. European Spine Journal, 22, 1173-1182.
https://doi.org/10.1007/s00586-012-2541-3
[10] Rodgers, W.B., Gerber, E.J., et al. (2012) Clinical and Radio-graphic Outcomes of Extreme Lateral Approach to Interbody Fusion with β-Tricalcium Phosphate and Hydroxyapatite Composite for Lumbar Degenerative Conditions. The International Journal of Spine Surgery, 6, 24-28.
[11] Gottfried, O.N. and Dailey, A.T. (2008) Mesenchymal Stem Cell and Gene Therapies for Spinal Fusion. Neurosurgery, 63, 380-391.
https://doi.org/10.1227/01.NEU.0000324990.04818.13
[12] 干耀恺, 戴尅戎, 张蒲, 等. 应用富集骨髓干细胞技术治疗骨缺损[J]. 中华骨科杂志, 2006, 26(11): 721-727.
[13] 许卫兵, 贾连顺, 卢建熙, 等. 兔骨髓基质干细胞体外培养复合β-磷酸三钙进行胸椎后侧融合实验研究[J]. 中国矫形外科杂志, 2005, 13(22): 1736-1738.
[14] Zhang, Y.Q., He, L.M., Xing, B., et al. (2012) Neurotrophin-3 Gene-Modified Schwann Cells Pro-mote TrkC Genemodified Mesenchymal Stem Cells to Differentiate into Neuron-Like Cells in Poly(lactic-acid-co-glycolic Acid) Multiple-Channel Conduit. Cells Tissues Organs, 195, 313-322.
https://doi.org/10.1159/000327724