度洛西汀中间体(S)-3-甲基氨基-1-(噻吩-2-基)丙醇合成工艺综述
Overview on the Synthesis of (S)-3-(Methyl-Amino)-1-(Thiophen-2-yl) Propan-1-ol
DOI: 10.12677/HJCET.2017.75029, PDF, HTML, XML, 下载: 1,750  浏览: 3,061  科研立项经费支持
作者: 吴佳佳, 季程宇, 谢童杰, 郝之奎, 徐 峰：台州职业技术学院化学制药研究所，浙江 台州；马良秀：浙江新东港药业股份有限公司，浙江 台州
关键词: 酶法；均相不对称催化剂；合成；度洛西汀；Enzymic Method； Asymmetry of Homogeneous Catalysts； Synthesis； Duloxetine
摘要: (S)-3-甲基氨基-1-(噻吩-2-基)丙醇是抗抑郁药度洛西汀的重要中间体。本文根据起始原料的不同，将其合成方法概括为：乙酰噻吩法、噻吩法和噻吩甲醛法，分析了各种方法的工艺特点，并指出了(S)-3-甲基氨基-1-(噻吩-2-基)丙醇未来的发展趋势。
Abstract: (S)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol is a class of important intermediate for anti-depressant R-Duloxetine. This paper summarized several methods to synthetize the compound according to its starting materials: starting from acetylthiophene, starting from thiophene, start-ing from thiophenecarboxaldehyde. The features of each method were analyzed. Finally, the de-velopment in the synthesis technology of (S)-3-(Methylamino)-1-(thiophen-2-yl) propan-1-ol was proposed.
文章引用：吴佳佳, 季程宇, 谢童杰, 马良秀, 郝之奎, 徐峰. 度洛西汀中间体(S)-3-甲基氨基-1-(噻吩-2-基)丙醇合成工艺综述[J]. 化学工程与技术, 2017, 7(5): 199-204. https://doi.org/10.12677/HJCET.2017.75029

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