[1]
|
Zeng, S.Y., Pöttler, M., Lan, B., et al. (2019) Chemoresistance in Pancreatic Cancer. International Journal of Molecular Sciences, 20, 4504. https://doi.org/10.3390/ijms20184504
|
[2]
|
Park, W., Chawla, A. and O’Reilly, E.M. (2021) Pancreatic Cancer: A Review. JAMA, 326, 851-862.
https://doi.org/10.1001/jama.2021.13027
|
[3]
|
刘迎澳, 吴文铭. 单细胞测序技术在胰腺癌领域应用现状和展望[J]. 中国实用外科杂志, 2021, 41(1): 56-59.
https://doi.org/10.19538/j.cjps.issn1005-2208.2021.01.09
|
[4]
|
武岳, 丁乙轩, 梅文通, 等. 胰腺星状细胞促进胰腺癌发展的研究进展[J]. 中华胰腺病杂志, 2021, 21(6): 476-480.
|
[5]
|
Saito, A., Horie, M. and Nagase, T. (2018) TGF-beta Signaling in Lung Health and Disease. International Journal of Molecular Sciences, 19, 2460. https://doi.org/10.3390/ijms19082460
|
[6]
|
David, C.J. and Massague, J. (2018) Contextual Determinants of TGFbeta Action in Development, Immunity and Cancer. Nature Reviews Molecular Cell Biology, 19, 419-435. https://doi.org/10.1038/s41580-018-0007-0
|
[7]
|
Derynck, R., Turley, S.J. and Akhurst, R.J. (2021) TGFbeta Bi-ology in Cancer Progression and Immunotherapy. Nature Reviews Clinical Oncology, 18, 9-34. https://doi.org/10.1038/s41571-020-0403-1
|
[8]
|
Katz, L.H., Li, Y., Chen, J.-S., et al. (2013) Targeting TGF-beta Signaling in Cancer. Expert Opinion on Therapeutic Targets, 17, 743-760. https://doi.org/10.1517/14728222.2013.782287
|
[9]
|
Derynck, R. and Zhang, Y.E. (2003) Smad-Dependent and Smad-Independent Pathways in TGF-beta Family Signalling. Nature, 425, 577-584. https://doi.org/10.1038/nature02006
|
[10]
|
Xie, F., Ling, L., Zhou, F.F., et al. (2018) TGF-beta Signaling in Cancer Metastasis. Acta Biochimica et Biophysica Sinica (Shanghai), 50, 121-132. https://doi.org/10.1093/abbs/gmx123
|
[11]
|
Morikawa, M., Derynck, R. and Miyazono, K. (2016) TGF-beta and the TGF-beta Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harbor Perspectives in Biology, 8, a021873.
https://doi.org/10.1101/cshperspect.a021873
|
[12]
|
Jiao, S.P., Subudhi, S.K., Aparicio, A., et al. (2019) Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy. Cell, 179, 1177-1190e13.
https://doi.org/10.1016/j.cell.2019.10.029
|
[13]
|
Wang, J., Xu, Z.H., Wang, Z., et al. (2021) TGF-beta Signaling in Cancer Radiotherapy. Cytokine, 12, 148.
https://doi.org/10.1016/j.cyto.2021.155709
|
[14]
|
Ma, X.Y., Cui, Z.W., Du, Z.D., et al. (2020) Transforming Growth Factor-beta Signaling, a Potential Mechanism Associated with Diabetes Mellitus and Pancreatic Cancer? Journal of Cellular Physiology, 235, 5882-5892.
https://doi.org/10.1002/jcp.29605
|
[15]
|
胡伟民, 常剑, 刘思卿. 肿瘤相关脂肪细胞在胰腺癌中的研究进展[J]. 中华胰腺病杂志, 2021, 21(3): 220-223.
https://mp.weixin.qq.com/s/97AdJnHu0BD8Etm47TmRjg
|
[16]
|
李静威, 王俐文, 蒋玲曦, 等. 胰腺癌免疫抑制性肿瘤微环境研究综述[J]. 上海交通大学学报(医学版), 2021. 41(8): 1103-1108. https://doi.org/10.3969/j.issn.1674-8115.2021.08.018
|
[17]
|
Peng, D.D., Fu, M.Y., Wang, M.N., et al. (2022) Targeting TGF-beta Signal Transduction for Fibrosis and Cancer Therapy. Molecular Cancer, 21, 104. https://doi.org/10.1186/s12943-022-01569-x
|
[18]
|
Liu, S., Ren, J. and Ten Dijke, P. (2021) Targeting TGFbeta Signal Transduction for Cancer Therapy. Signal Transduction and Targeted Therapy, 6, 8. https://doi.org/10.1038/s41392-020-00436-9
|
[19]
|
Yoshida, G.J. (2020) Regulation of Heterogeneous Can-cer-Associated Fibroblasts: The Molecular Pathology of Activated Signaling Pathways. Journal of Experimental & Clinical Cancer Research, 39, 112.
https://doi.org/10.1186/s13046-020-01611-0
|
[20]
|
Buechler, M.B., Pradhan, R.N., Krishnamurty, A.T., et al. (2021) Cross-Tissue Organization of the Fibroblast Lineage. Nature, 593, 575-579. https://doi.org/10.1038/s41586-021-03549-5
|
[21]
|
Sahai, E., Astsaturov, I., Cukierman, E., et al. (2020) A Framework for Advancing Our Understanding of Cancer-Associated Fibroblasts. Nature Reviews Cancer, 20, 174-186. https://doi.org/10.1038/s41568-019-0238-1
|
[22]
|
Wei, L.S., Lin, Q., Lu, Y.N., et al. (2021) Cancer-Associated Fibroblasts-Mediated ATF4 Expression Promotes Malignancy and Gemcitabine Resistance in Pancreatic Cancer via the TGF-beta1/SMAD2/3 Pathway and ABCC1 Transactivation. Cell Death & Disease, 12, Article No. 334. https://doi.org/10.1038/s41419-021-03574-2
|
[23]
|
Zhang, Y.F., Jiang, S.H., Hu, L.P., et al. (2019) Targeting the Tumor Microenvironment for Pancreatic Ductal Adenocarcinoma Therapy. Chinese Clinical Oncology, 8, Article No. 18. https://doi.org/10.21037/cco.2019.03.02
|
[24]
|
Hilbig, A. and Oettle, H. (2011) Transforming Growth Factor Beta in Pancreatic Cancer. Current Pharmaceutical Biotechnology, 12, 2158-2164. https://doi.org/10.2174/138920111798808356
|
[25]
|
Mahadevan, D. and Von Hoff, D.D. (2007) Tumor-Stroma Interactions in Pancreatic Ductal Adenocarcinoma. Molecular Cancer Therapeutics, 6, 1186-1197. https://doi.org/10.1158/1535-7163.MCT-06-0686
|
[26]
|
Li, S., Xu, H.X., Wu, C.T., et al. (2019) Angiogenesis in Pancreatic Cancer: Current Research Status and Clinical Implications. Angiogenesis, 22, 15-36. https://doi.org/10.1007/s10456-018-9645-2
|
[27]
|
Anderson, K.G., Stromnes, I.M. and Greenberg, P.D. (2017) Obstacles Posed by the Tumor Microenvironment to T Cell Activity: A Case for Synergistic Therapies. Cancer Cell, 31, 311-325. https://doi.org/10.1016/j.ccell.2017.02.008
|
[28]
|
Colegio, O.R., Chu, N.-Q., Szabo, A.L., et al. (2014) Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid. Nature, 513, 559-563. https://doi.org/10.1038/nature13490
|
[29]
|
Costache, M.I., Ioana, M., Iordache, S., et al. (2015) VEGF Expression in Pancreatic Cancer and Other Malignancies: A Review of the Literature. Romanian Journal of Internal Medicine, 53, 199-208.
https://doi.org/10.1515/rjim-2015-0027
|
[30]
|
Liang, Q.-L., Wang, B.-R., Chen, G.-Q., et al. (2010) Clinical Sig-nificance of Vascular Endothelial Growth Factor and Connexin43 for Predicting Pancreatic Cancer Clinicopathologic Parameters. Medical Oncology, 27, 1164-1170.
https://doi.org/10.1007/s12032-009-9354-1
|
[31]
|
Muppala, S., Xiao, R., Krukovets, I., et al. (2017) Thrombospondin-4 Mediates TGF-beta-Induced Angiogenesis. Oncogene, 36, 5189-5198. https://doi.org/10.1038/onc.2017.140
|
[32]
|
Lodyga, M. and Hinz, B. (2020) TGF-beta1—A Truly Transforming Growth Factor in Fibrosis and Immunity. Seminars in Cell & Developmental Biology, 101, 123-139. https://doi.org/10.1016/j.semcdb.2019.12.010
|
[33]
|
Dimeloe, S., Gubser, P., Loeliger, J., et al. (2019) Tu-mor-Derived TGF-beta Inhibits Mitochondrial Respiration to Suppress IFN-gamma Production by Human CD4(+) T Cells. Science Signaling, 12, eaav3334.
https://doi.org/10.1126/scisignal.aav3334
|
[34]
|
Sanjabi, S., Mosaheb, M.M. and Flavell, R.A. (2009) Opposing Effects of TGF-beta and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells. Immunity, 31, 131-144. https://doi.org/10.1016/j.immuni.2009.04.020
|
[35]
|
Tinoco, R., Alcalde, V., Yang, Y.T., et al. (2009) Cell-Intrinsic Transforming Growth Factor-beta Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence in Vivo. Immunity, 31, 145-157.
https://doi.org/10.1016/j.immuni.2009.06.015
|
[36]
|
Li, S., Liu, M., Do, M.H., et al. (2020) Cancer Immunotherapy via Targeted TGF-beta Signalling Blockade in TH Cells. Nature, 587, 121-125. https://doi.org/10.1038/s41586-020-2850-3
|
[37]
|
Brabletz, S., Schuhwerk, H., Brabletz, T., et al. (2021) Dynamic EMT: A Multi-Tool for Tumor Progression. EMBO Journal, 40, e108647. https://doi.org/10.15252/embj.2021108647
|
[38]
|
Nowak, E. and Bednarek, I. (2021) Aspects of the Epigenetic Regulation of EMT Related to Cancer Metastasis. Cells, 10, 3435. https://doi.org/10.3390/cells10123435
|
[39]
|
Xie, F., Zhang, Z.K., van Dam, H., et al. (2014) Regulation of TGF-Beta Superfamily Signaling by SMAD Mono-Ubiquitination. Cells, 3, 981-993. https://doi.org/10.3390/cells3040981
|
[40]
|
Ramirez, M., Stempor, P.A. and Bulgakova, N.A. (2021) Interactions and Feedbacks in E-Cadherin Transcriptional Regulation. Frontiers in Cell and Developmental Biology, 9, Article ID: 701175.
https://doi.org/10.3389/fcell.2021.701175
|
[41]
|
David, C.J., Huang, Y.-H., Chen, M., et al. (2016) TGF-beta Tu-mor Suppression through a Lethal EMT. Cell, 164, 1015-1030. https://doi.org/10.1016/j.cell.2016.01.009
|
[42]
|
Galluzzi, L., Baehrecke, E.H., Ballabio, A., et al. (2017) Molecular Definitions of Autophagy and Related Processes. EMBO Journal, 36, 1811-1836.
|
[43]
|
Wang, Y.Y., Qin, C., Yang, G., et al. (2021) The Role of Autophagy in Pancreatic Cancer Progression. Biochimica et Biophysica Acta—Reviews on Cancer, 1876, Article ID: 188592. https://doi.org/10.1016/j.bbcan.2021.188592
|
[44]
|
Zhao, M., Mishra, L. and Deng, C.X. (2018) The Role of TGF-beta/SMAD4 Signaling in Cancer. International Journal of Biological Sciences, 14, 111-123. https://doi.org/10.7150/ijbs.23230
|
[45]
|
Liang, C., Xu, J., Meng, Q.C., et al. (2020) TGFB1-Induced Autophagy Affects the Pattern of Pancreatic Cancer Progression in Distinct Ways Depending on SMAD4 Status. Au-tophagy, 16, 486-500.
https://doi.org/10.1080/15548627.2019.1628540
|