[1]
|
Ganesh, A., Luengo-Fernandez, R., Wharton, R.M., et al. (2017) Time Course of Evolution of Disability and Cause-Specific Mortality after Ischemic Stroke: Implications for Trial Design. Journal of the American Heart Association, 6, e005788. https://doi.org/10.1161/JAHA.117.005788
|
[2]
|
Rhim, T., Lee, D.Y. and Lee, M. (2013) Hypoxia as a Target for Tissue Specific Gene Therapy. Journal of Controlled Release, 172, 484-494. https://doi.org/10.1016/j.jconrel.2013.05.021
|
[3]
|
Yu, M., Pan, Q., Li, W., et al. (2023) Isoliquiritigenin Inhibits Gastric Cancer Growth through Suppressing GLUT4 Mediated Glucose Uptake and Inducing PDHK1/PGC-1α Mediat-ed Energy Metabolic Collapse. Phytomedicine, 121, Article ID: 155045. https://doi.org/10.1016/j.phymed.2023.155045
|
[4]
|
Rattner, A., Williams, J. and Nathans, J. (2019) Roles of HIFs and VEGF in Angiogenesis in the Retina and Brain. Journal of Clinical Investigation, 129, 3807-3820. https://doi.org/10.1172/JCI126655
|
[5]
|
Wu, Y., Zhang, L., Sun, Z., et al. (2023) Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia. Journal of Me-dicinal Chemistry, 66, 8545-8563.
https://doi.org/10.1021/acs.jmedchem.3c00231
|
[6]
|
Qiu, B., Yuan, P., Du, X., et al. (2023) Hypoxia Inducible Factor-1α Is an Important Regulator of Macrophage Biology. Heliyon, 9, e17167. https://doi.org/10.1016/j.heliyon.2023.e17167
|
[7]
|
Chen, W., Jadhav, V., Tang, J., et al. (2008) HIF-1alpha Inhibi-tion Ameliorates Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model. Neurobiology of Disease, 31, 433-441. https://doi.org/10.1016/j.nbd.2008.05.020
|
[8]
|
Helton, R., Cui, J., Scheel, J.R., et al. (2005) Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1alpha Reduces Rather than Increases Hypoxic-Ischemic Damage. Journal of Neuroscience, 25, 4099-4107.
https://doi.org/10.1523/JNEUROSCI.4555-04.2005
|
[9]
|
Xie, Y., Shi, X., Sheng, K., et al. (2019) PI3K/Akt Sig-naling Transduction Pathway, Erythropoiesis and Glycolysis in Hypoxia (Review). Molecular Medicine Reports, 19, 783-791. https://doi.org/10.3892/mmr.2018.9713
|
[10]
|
Wang, G.L., Jiang, B.H., Rue, E.A., et al. (1995) Hypox-ia-Inducible Factor 1 Is a Basic-Helix-Loop-Helix-PAS Heterodimer Regulated by Cellular O2 Tension. Proceedings of the National Academy of Sciences of the United States of America, 92, 5510-5514. https://doi.org/10.1073/pnas.92.12.5510
|
[11]
|
Wu, Y., Li, Z., Mcdonough, M.A., et al. (2021) Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy. Journal of Medicinal Chemistry, 64, 7189-7209. https://doi.org/10.1021/acs.jmedchem.1c00415
|
[12]
|
Masoud, G.N. and Li, W. (2015) HIF-1α Pathway: Role, Reg-ulation and Intervention for Cancer Therapy. Acta Pharmaceutica Sinica B, 5, 378-389. https://doi.org/10.1016/j.apsb.2015.05.007
|
[13]
|
Semenza, G.L. (2001) HIF-1, O(2), and the 3 PHDs: How Animal Cells Signal Hypoxia to the Nucleus. Cell, 107, 1-3.
https://doi.org/10.1016/S0092-8674(01)00518-9
|
[14]
|
Wenger, R.H., Stiehl, D.P. and Camenisch, G. (2005) Inte-gration of Oxygen Signaling at the Consensus HRE. Science’s STKE, 2005, re12. https://doi.org/10.1126/stke.3062005re12
|
[15]
|
Vangeison, G., Carr, D., Federoff, H.J., et al. (2008) The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1 Alpha in Neurons and Astrocytes. Journal of Neu-roscience, 28, 1988-1993.
https://doi.org/10.1523/JNEUROSCI.5323-07.2008
|
[16]
|
Hirayama, Y., Anzai, N. and Koizumi, S. (2021) Mecha-nisms Underlying Sensitization of P2X7 Receptors in Astrocytes for Induction of Ischemic Tolerance. Glia, 69, 2100-2110. https://doi.org/10.1002/glia.23998
|
[17]
|
Hirayama, Y., Ikeda-Matsuo, Y., Notomi, S., et al. (2015) As-trocyte-Mediated Ischemic Tolerance. Journal of Neuroscience, 35, 3794-3805. https://doi.org/10.1523/JNEUROSCI.4218-14.2015
|
[18]
|
Kong, L., Ma, Y., Wang, Z., et al. (2021) Inhibition of Hypoxia Inducible Factor 1 by YC-1 Attenuates Tissue Plasminogen Activator Induced Hemorrhagic Transformation by Suppressing HMGB1/TLR4/NF-κB Mediated Neutrophil Infiltration in Thromboembolic Stroke Rats. International Immunopharmacology, 94, Article ID: 107507.
https://doi.org/10.1016/j.intimp.2021.107507
|
[19]
|
Bok, S., Kim, Y.-E., Woo, Y., et al. (2017) Hypoxia-Inducible Factor-1α Regulates Microglial Functions Affecting Neuronal Survival in the Acute Phase of Ischemic Stroke in Mice. Oncotarget, 8, 111508-111521.
https://doi.org/10.18632/oncotarget.22851
|
[20]
|
Mergenthaler, P., Lindauer, U., Dienel, G.A., et al. (2013) Sugar for the Brain: The Role of Glucose in Physiological and Pathological Brain Function. Trends in Neurosciences, 36, 587-597. https://doi.org/10.1016/j.tins.2013.07.001
|
[21]
|
Guo, S., Miyake, M., Liu, K.J., et al. (2009) Specific In-hibition of Hypoxia Inducible Factor 1 Exaggerates Cell Injury Induced by in Vitro Ischemia through Deteriorating Cel-lular Redox Environment. Journal of Neurochemistry, 108, 1309-1321. https://doi.org/10.1111/j.1471-4159.2009.05877.x
|
[22]
|
Quaegebeur, A., Segura, I., Schmieder, R., et al. (2016) Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metabolism, 23, 280-291.
https://doi.org/10.1016/j.cmet.2015.12.007
|
[23]
|
Guo, S., Bragina, O., Xu, Y., et al. (2008) Glucose Up-Regulates HIF-1 Alpha Expression in Primary Cortical Neurons in Response to Hypoxia through Maintaining Cellular Redox Sta-tus. Journal of Neurochemistry, 105, 1849-1860.
https://doi.org/10.1111/j.1471-4159.2008.05287.x
|
[24]
|
Bernaudin, M., Nedelec, A.-S., Divoux, D., et al. (2002) Normobaric Hypoxia Induces Tolerance to Focal Permanent Cerebral Ischemia in Association with an Increased Expres-sion of Hypoxia-Inducible Factor-1 and Its Target Genes, Erythropoietin and VEGF, in the Adult Mouse Brain. Journal of Cerebral Blood Flow & Metabolism, 22, 393-403.
https://doi.org/10.1097/00004647-200204000-00003
|
[25]
|
Yan, J., Zhou, B., Taheri, S., et al. (2011) Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Is-chemic Stroke. PLOS ONE, 6, e27798.
https://doi.org/10.1371/journal.pone.0027798
|
[26]
|
Formisano, L., Guida, N., Mascolo, L., et al. (2020) Transcrip-tional and Epigenetic Regulation of ncx1 and ncx3 in the Brain. Cell Calcium, 87, Article ID: 102194. https://doi.org/10.1016/j.ceca.2020.102194
|
[27]
|
Valsecchi, V., Pignataro, G., Del Prete, A., et al. (2011) NCX1 Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain Preconditioning. Stroke, 42, 754-763. https://doi.org/10.1161/STROKEAHA.110.597583
|
[28]
|
Jin, W., Zhao, J., Yang, E., et al. (2022) Neuronal STAT3/HIF-1α/PTRF Axis-Mediated Bioenergetic Disturbance Exacerbates Cerebral Ischemia-Reperfusion Injury via PLA2G4A. Theranostics, 12, 3196-3216.
https://doi.org/10.7150/thno.71029
|
[29]
|
El Kossi, M.M. and Zakhary, M.M. (2000) Oxidative Stress in the Context of Acute Cerebrovascular Stroke. Stroke, 31, 1889-1892. https://doi.org/10.1161/01.STR.31.8.1889
|
[30]
|
Wu, L.-Y., He, Y.-L. and Zhu, L.-L. (2018) Possible Role of PHD Inhibitors as Hypoxia-Mimicking Agents in the Maintenance of Neural Stem Cells’ Self-Renewal Properties. Frontiers in Cell and Developmental Biology, 6, Article No. 169. https://doi.org/10.3389/fcell.2018.00169
|
[31]
|
Guzy, R.D., Hoyos, B., Robin, E., et al. (2005) Mitochondrial Com-plex III Is Required for Hypoxia-Induced ROS Production and Cellular Oxygen Sensing. Cell Metabolism, 1, 401-408. https://doi.org/10.1016/j.cmet.2005.05.001
|
[32]
|
Lluis, J.M., Buricchi, F., Chiarugi, P., et al. (2007) Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor-{kappa}B via c-SRC and Oxidant-Dependent Cell Death. Cancer Research, 67, 7368-7377. https://doi.org/10.1158/0008-5472.CAN-07-0515
|
[33]
|
Matrone, C., Pignataro, G., Molinaro, P., et al. (2004) HIF-1alpha Reveals a Binding Activity to the Promoter of iNOS Gene after Permanent Middle Cerebral Artery Occlusion. Journal of Neurochemistry, 90, 368-378.
https://doi.org/10.1111/j.1471-4159.2004.02483.x
|
[34]
|
Hewett, S.J., Muir, J.K., Lobner, D., et al. (1996) Potentia-tion of Oxygen-Glucose Deprivation-Induced Neuronal Death after Induction of iNOS. Stroke, 27, 1586-1591. https://doi.org/10.1161/01.STR.27.9.1586
|
[35]
|
Fang, L.Q., Xu, H., Sun, Y., et al. (2012) Induction of Inducible Nitric Oxide Synthase by Isoflurane Post-Conditioning via Hypoxia Inducible Factor-1α during Tolerance against Is-chemic Neuronal Injury. Brain Research, 1451, 1-9.
https://doi.org/10.1016/j.brainres.2012.02.055
|
[36]
|
Semenza, G.L. (2014) Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology. Annual Review of Pathology, 9, 47-71. https://doi.org/10.1146/annurev-pathol-012513-104720
|
[37]
|
Sun, P., Zhang, K., Hassan, S.H., et al. (2020) Endo-thelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neuro-logical Recovery. Circulation Research, 126, 1040-1057.
https://doi.org/10.1161/CIRCRESAHA.119.315886
|
[38]
|
Abdel-Latif, R.G., Rifaai, R.A. and Amin, E.F. (2020) Empagliflozin Alleviates Neuronal Apoptosis Induced by Cerebral Ischemia/Reperfusion Injury through HIF-1α/VEGF Signaling Pathway. Archives of Pharmacal Research, 43, 514-525. https://doi.org/10.1007/s12272-020-01237-y
|
[39]
|
Daneman, R., Zhou, L., Kebede, A.A., et al. (2010) Pericytes Are Required for Blood-Brain Barrier Integrity during Embryogenesis. Nature, 468, 562-566. https://doi.org/10.1038/nature09513
|
[40]
|
Tsao, C.-C., Baumann, J., Huang, S.-F., et al. (2021) Pericyte Hypox-ia-Inducible Factor-1 (HIF-1) Drives Blood-Brain Barrier Disruption and Impacts Acute Ischemic Stroke Outcome. An-giogenesis, 24, 823-842.
https://doi.org/10.1007/s10456-021-09796-4
|
[41]
|
Allen, N.J. and Lyons, D.A. (2018) Glia as Architects of Central Nervous System Formation and Function. Science, 362, 181-185. https://doi.org/10.1126/science.aat0473
|
[42]
|
Borst, K., Dumas, A.A. and Prinz, M. (2021) Microglia: Immune and Non-Immune Functions. Immunity, 54, 2194-2208. https://doi.org/10.1016/j.immuni.2021.09.014
|
[43]
|
Freeman, M.R. (2010) Specification and Morphogenesis of Astrocytes. Science, 330, 774-778.
https://doi.org/10.1126/science.1190928
|
[44]
|
Yates, D. (2017) Glia: A Toxic Reaction. Nature Reviews Neurosci-ence, 18, 130. https://doi.org/10.1038/nrn.2017.13
|
[45]
|
Chen, C., Ostrowski, R.P., Zhou, C., et al. (2010) Sup-pression of Hypoxia-Inducible Factor-1alpha and Its Downstream Genes Reduces Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Rat Model of Cerebral Ischemia. Journal of Neuroscience Research, 88, 2046-2055. https://doi.org/10.1002/jnr.22361
|
[46]
|
Mojsilovic-Petrovic, J., Callaghan, D., Cui, H., et al. (2007) Hypox-ia-Inducible Factor-1 (HIF-1) Is Involved in the Regulation of Hypoxia-Stimulated Expression of Monocyte Chemoat-tractant Protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in Astrocytes. Journal of Neuroinflammation, 4, Article No. 12. https://doi.org/10.1186/1742-2094-4-12
|
[47]
|
Tsan, M.-F. (2006) Toll-Like Receptors, Inflammation and Cancer. Seminars in Cancer Biology, 16, 32-37.
https://doi.org/10.1016/j.semcancer.2005.07.004
|
[48]
|
Fang, H., Wang, P.F., Zhou, Y., et al. (2013) Toll-Like Re-ceptor 4 Signaling in Intracerebral Hemorrhage-Induced Inflammation and Injury. Journal of Neuroinflammation, 10, Ar-ticle No. 794. https://doi.org/10.1186/1742-2094-10-27
|
[49]
|
Rius, J., Guma, M., Schachtrup, C., et al. (2008) NF-kappaB Links Innate Immunity to the Hypoxic Response through Transcriptional Regulation of HIF-1alpha. Nature, 453, 807-811. https://doi.org/10.1038/nature06905
|
[50]
|
Yao, L., Kan, E.M., Lu, J., et al. (2013) Toll-Like Receptor 4 Mediates Microglial Activation and Production of Inflammatory Mediators in Neonatal Rat Brain Following Hypoxia: Role of TLR4 in Hypoxic Microglia. Journal of Neuroinflammation, 10, Article No. 23. https://doi.org/10.1186/1742-2094-10-23
|
[51]
|
An, P., Xie, J., Qiu, S., et al. (2019) Hispidulin Exhibits Neuropro-tective Activities against Cerebral Ischemia Reperfusion Injury through Suppressing NLRP3-Mediated Pyroptosis. Life Sciences, 232, Article ID: 116599.
https://doi.org/10.1016/j.lfs.2019.116599
|
[52]
|
Yuan, D., Guan, S., Wang, Z., et al. (2021) HIF-1α Aggravated Traumatic Brain Injury by NLRP3 Inflammasome-Mediated Pyroptosis and Activation of Microglia. Journal of Chemical Neuroanatomy, 116, Article ID: 101994.
https://doi.org/10.1016/j.jchemneu.2021.101994
|
[53]
|
Taylor, C.T. and Scholz, C.C. (2022) The Effect of HIF on Metabolism and Immunity. Nature Reviews Nephrology, 18, 573-587. https://doi.org/10.1038/s41581-022-00587-8
|
[54]
|
Giulian, D. (1993) Reactive Glia as Rivals in Regulating Neu-ronal Survival. Glia, 7, 102-110.
https://doi.org/10.1002/glia.440070116
|
[55]
|
Liddelow, S.A., Guttenplan, K.A., Clarke, L.E., et al. (2017) Neuro-toxic Reactive Astrocytes Are Induced by Activated Microglia. Nature, 541, 481-487. https://doi.org/10.1038/nature21029
|
[56]
|
Pollay, M. (2010) The Function and Structure of the Cerebrospinal Fluid Outflow System. Cerebrospinal Fluid Research, 7, Article No. 9. https://doi.org/10.1186/1743-8454-7-9
|
[57]
|
Rasmussen, M.K., Mestre, H. and Nedergaard, M. (2018) The Glym-phatic Pathway in Neurological Disorders. The Lancet Neurology, 17, 1016-1024. https://doi.org/10.1016/S1474-4422(18)30318-1
|
[58]
|
Iliff, J.J., Wang, M., Liao, Y., et al. (2012) A Paravascular Pathway Facilitates CSF Flow through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Science Translational Medicine, 4, 147ra11.
https://doi.org/10.1126/scitranslmed.3003748
|
[59]
|
Mestre, H., Hablitz, L.M., Xavier, A.L., et al. (2018) Aqua-porin-4-Dependent Glymphatic Solute Transport in the Rodent Brain. Elife, 7, e40070. https://doi.org/10.7554/eLife.40070
|
[60]
|
Xiong, A., Li, J., Xiong, R., et al. (2022) Inhibition of HIF-1α-AQP4 Axis Ameliorates Brain Edema and Neurological Functional Deficits in a Rat Controlled Cortical Injury (CCI) Model. Scientific Reports, 12, Article No. 2701.
https://doi.org/10.1038/s41598-022-06773-9
|
[61]
|
Leng, F. and Edison, P. (2021) Neuroinflammation and Micro-glial Activation in Alzheimer Disease: Where Do We Go from Here? Nature Reviews Neurology, 17, 157-172. https://doi.org/10.1038/s41582-020-00435-y
|
[62]
|
Yun, S.P., Kam, T.-I., Panicker, N., et al. (2018) Block of A1 Astrocyte Conversion by Microglia Is Neuroprotective in Models of Parkinson’s Disease. Nature Medicine, 24, 931-938. https://doi.org/10.1038/s41591-018-0051-5
|
[63]
|
Vidal-Itriago, A., Radford, R.A.W., Aramideh, J.A., et al. (2022) Microglia Morphophysiological Diversity and Its Implications for the CNS. Frontiers in Immunology, 13, Article ID: 997786.
https://doi.org/10.3389/fimmu.2022.997786
|
[64]
|
Ikeda, T., Xia, X.Y., Xia, Y.X., et al. (2000) Glial Cell Line-Derived Neurotrophic Factor Protects against Ischemia/Hypoxia-Induced Brain Injury in Neonatal Rat. Acta Neu-ropathologica, 100, 161-167.
https://doi.org/10.1007/s004019900162
|
[65]
|
Te Boekhorst, V., Jiang, L., Mählen, M., et al. (2022) Calpain-2 Reg-ulates Hypoxia/HIF-Induced Plasticity toward Amoeboid Cancer Cell Migration and Metastasis. Current Biology, 32, 412-427.E8.
https://doi.org/10.1016/j.cub.2021.11.040
|
[66]
|
Deng, H., Tian, X., Sun, H., et al. (2022) Calpain-1 Mediates Vas-cular Remodelling and Fibrosis via HIF-1α in Hypoxia-Induced Pulmonary Hypertension. Journal of Cellular and Mo-lecular Medicine, 26, 2819-2830.
https://doi.org/10.1111/jcmm.17295
|
[67]
|
Yeh, S.-H., Ou, L.-C., Gean, P.-W., et al. (2011) Selective Inhibition of Early—but Not Late—Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage. Brain Patholo-gy, 21, 249-262.
https://doi.org/10.1111/j.1750-3639.2010.00443.x
|
[68]
|
Peña-Blanco, A. and García-Sáez, A.J. (2018) Bax, Bak and Beyond-Mitochondrial Performance in Apoptosis. The FEBS Journal, 285, 416-431. https://doi.org/10.1111/febs.14186
|
[69]
|
Chen, D., Li, M., Luo, J., et al. (2003) Direct Interactions between HIF-1 Alpha and Mdm2 Modulate p53 Function. Journal of Biological Chemistry, 278, 13595-13598. https://doi.org/10.1074/jbc.C200694200
|
[70]
|
Li, J., Tao, T., Xu, J., et al. (2020) HIF-1α Attenuates Neuronal Apoptosis by Upregulating EPO Expression Following Cerebral Ischemia-Reperfusion Injury in a Rat MCAO Model. International Journal of Molecular Medicine, 45, 1027-1036. https://doi.org/10.3892/ijmm.2020.4480
|
[71]
|
Garibotto, G., Gurreri, G., Robaudo, C., et al. (1993) Erythropoietin Treatment and Amino Acid Metabolism in Hemodialysis Patients. Nephron, 65, 533-536. https://doi.org/10.1159/000187559
|
[72]
|
Kang, Y.-J., Digicaylioglu, M., Russo, R., et al. (2010) Erythropoietin plus Insulin-Like Growth Factor-I Protects against Neuronal Damage in a Murine Model of Human Immunodeficiency Vi-rus-Associated Neurocognitive Disorders. Annals of Neurology, 68, 342-352. https://doi.org/10.1002/ana.22070
|
[73]
|
Naama, M. and Bel, S. (2023) Autophagy-ER Stress Crosstalk Controls Mucus Secretion and Susceptibility to Gut Inflammation. Autophagy, 19, 3014-3016. https://doi.org/10.1080/15548627.2023.2228191
|
[74]
|
Jaeger, P.A. and Wyss-Coray, T. (2009) All-You-Can-Eat: Autophagy in Neurodegeneration and Neuroprotection. Molecular Neurodegeneration, 4, Article No. 16. https://doi.org/10.1186/1750-1326-4-16
|
[75]
|
Lu, N., Li, X., Tan, R., et al. (2018) HIF-1α/Beclin1-Mediated Au-tophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning. Journal of Molecular Neuroscience, 66, 238-250.
https://doi.org/10.1007/s12031-018-1162-7
|
[76]
|
Niu, G., Zhu, D., Zhang, X., et al. (2018) Role of Hypox-ia-Inducible Factors 1α (HIF1α) in SH-SY5Y Cell Autophagy Induced by Oxygen-Glucose Deprivation. Medical Sci-ence Monitor, 24, 2758-2766.
https://doi.org/10.12659/MSM.905140
|
[77]
|
Daskalaki, I., Gkikas, I. and Tavernarakis, N. (2018) Hypoxia and Se-lective Autophagy in Cancer Development and Therapy. Frontiers in Cell and Developmental Biology, 6, Article No. 104. https://doi.org/10.3389/fcell.2018.00104
|
[78]
|
Wang, Y., Dong, X.-X., Cao, Y., et al. (2009) p53 Induction Con-tributes to Excitotoxic Neuronal Death in Rat Striatum through Apoptotic and Autophagic Mechanisms. European Jour-nal of Neuroscience, 30, 2258-2270.
https://doi.org/10.1111/j.1460-9568.2009.07025.x
|
[79]
|
Zhang, H., Bosch-Marce, M., Shimoda, L.A., et al. (2008) Mitochondrial Autophagy Is an HIF-1-Dependent Adaptive Metabolic Response to Hypoxia. Journal of Biological Chemistry, 283, 10892-10903.
https://doi.org/10.1074/jbc.M800102200
|