香菇多糖联合顺铂、地塞米松经胸腔中心静脉导管注入治疗老年肺癌恶性胸腔积液的临床观察

The Clinical Observation about Lentinan plus Cisplatin and Dexamethasone Treatment for Elderly Lung Cancer with Malignant Pleural Effusions by Central Venous Catheters Drainage

摘要: 目的：观察香菇多糖联合顺铂、地塞米松经胸腔中心静脉导管注入治疗老年肺癌恶性胸腔积液的临床应用，评估其近期疗效及不良反应。方法：对36例老年肺癌恶性胸腔积液患者，采用胸腔留置中心静脉导管充分引流胸腔积液后，随机分治疗组(n = 19)及对照组(n = 17)，治疗组胸腔内注射香菇多糖、顺铂、地塞米松，对照组胸腔内注射顺铂、地塞米松，均为7天一次，连续最多4次。评价两组的近期疗效和不良反应。结果：治疗组有效率为84.2%，不良反应轻。对照组有效率为64.7%。结论：香菇多糖联合顺铂、地塞米松经胸腔中心静脉导管注入治疗老年肺癌恶性胸腔积液疗效肯定，不良反应少，是有效治疗老年肺癌恶性胸腔积液的方法之一。

Abstract: Objective: To observe the clinical use of lentinan plus cisplatin and dexamethasone in elderly lung cancer with malignant pleural effusions by central venous catheters drainage, appraise its recent effect and adverse reactions. Methods: 36 elderly lung cancer patients with malignant pleural effusions by central venous catheters drainage were random divided into treatment group (n = 19) and control group (n = 17). The treatment group was injected into pleural cavity with lentinan Plus cisplatin and dexamethasone, and the control group was injected into pleural cavity with cisplatin and dexamethasone. They were respectively given seven days once, and continuous at most four times to evaluate recent effect and adverse reactions of two groups. Results: The total effective rates of treatment group were 84.2%, and adverse reactions were less. The total effective rate of control group was 64.7%. Conclusion: The clinical effect of lentinan plus cisplatin and dexamethasone in elderly lung cancer with malignant pleural effusions by central venous catheters drainage is certain and adverse reactions are less. It is one of the effective methods to control the elderly lung cancer with malignant pleural effusions.