标题:
鹅去氧胆酸的氧化产物合成The Synthesis of the Oxidation of Chenodeoxycholic Acid
作者:
蔡烈峰
关键字:
鹅去氧胆酸, 氧化, 合成Chenodeoxycholic Acid, Oxidation, Synthesis
期刊名称:
《Hans Journal of Medicinal Chemistry》, Vol.3 No.2, 2015-05-11
摘要:
目的：选择性氧化得到鹅去氧胆酸不同位置的氧化产物。方法：使用碳酸银作氧化剂得到3位羟基被氧化的产物；使用N-溴代丁二酰二胺作氧化剂得到7位羟基被氧化产物；使用琼斯试剂作氧化剂得到3位和7位羟基均被氧化的产物。结果：本工艺提供的选择性氧化方法成本更低，收率更高，后处理更方便，适合工业化生产。结论：本文所选择的方法具有条件温和，操作简单，成本低，收率高，适合工业化大生产的优点。
Objective: Regioselective oxidation of chenodeoxycholic acid in different positions. Methods: The third was oxidized with silver carbonate; the seventh was oxidized with N-bromosuccinimide; the third and the seventh were oxidized with Jones reagent. Results: The synethesis of regioselective oxidation of chenodeoxycholic acid has advantages such as lower cost, higher yield, easier in aftertreatment and more suitable for industrialized production. Conclusion: This synthetic process has advantages such as mild conditions, easy operation, low cost and high yield, and is suitable for large-scale production.