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肿瘤预后相关免疫抑制分子概述The Overview of Tumor-Related Immunosuppressive Molecules
张冬云, 刘冉, 刘安丽, 李寅, 王静
肿瘤, 免疫, 免疫抑制分子, 综述Tumor, Immune, Immunosuppressive Molecules, Overview
《Advances in Clinical Medicine》, Vol.5 No.2, 2015-06-12
肿瘤机体内免疫抑制细胞、免疫抑制分子状态与肿瘤发生、发展密切相关。本文综述了肿瘤免疫过程中参与肿瘤免疫逃逸的免疫抑制分子PD-1，CTLA-4，TIM-3，LAG-3，CD160，BTLA的功能状况及最新研究进展。Tumorigenesis was closely related to the states of immune tumor suppressor cells and immuno-suppressive molecules. In the paper, we overviewed current functional situation and newly re-search progress of immunosuppressive molecules, e.g. programmed death-1, cytotoxic T lympho-cyte-associated antigen-4, T cell immunoglobulin domain and mucin domain-3, B and T lymphocyte attenuator, LAG-3, CD160, which took part in the tumor immune escape in the process of tumor immunity.