T. Mori, T. Nakamura, N. Okazaki, A. Furukohri, H. Maki and M. T. Akiyama. Escherichia coli DinB inhibits replication fork progression without significantly inducing the SOS response. Genes and Genetic Systems, 2012, 87(2): 75-87.
细菌DNA损伤诱导反应(SOS 反应)在控制细菌耐药性中的作用Role of DNA Damage Response (SOS response) on the Control of Bacterial Resistance
细菌, SOS反应, 耐药性, RecABacterium; SOS Response; Drug Resistance; RecA
《Advances in Microbiology》, Vol.2 No.3, 2013-08-21
Bacterial drug resistance is one of the world’s most pressing public health threats. Especially in today, new antimicrobial drugs are no longer being developed at a rate that can keep pace with microbial evolution. The mechanism for the emergence, spread and reversion of bacterial resistance has become a research hotspot. Recently, it has been proved that bacterial DNA damage response (also named SOS response) acts an important role in the evolution of drug resistance. Here, we reviewed the relation between SOS response and bacterial drug resistance.