标题:
循环microRNAs在乳腺癌诊治中的应用The Diagnostic and Therapeutic Application of Circulating microRNAs in Breast Cancer
作者:
薛丽, 白玉杰
关键字:
微小核糖核酸, 乳腺癌, 生物标志, 诊断, 治疗microRNA, Breast Cancer, Biomarker, Diagnosis, Therapy
期刊名称:
《Medical Diagnosis》, Vol.5 No.3, 2015-09-29
摘要:
微小核糖核酸(microRNAs, miRNAs)是一类具有调控功能的小分子非编码核糖核酸，与肿瘤的发生有密切关系。大量研究也充分证实了miRNAs在乳腺癌中的作用。循环miRNAs (circulating miRNAs)指存在于血液或其他体液中的细胞外游离microRNAs，具有稳定性好、取材方便、创伤小，可反复取样检测等优点，且与肿瘤发生和发展相关，因此被认为是最具潜力的肿瘤标志之一。本综述主要总结循环miRNAs在乳腺癌早期诊断、预后预测及指导治疗等方面研究及其临床应用进展，并探讨循环miRNAs临床应用所面临的挑战和需解决的问题。
MicroRNAs (miRNAs)
are a class of short non-coding regulatory RNAs with an etiological contribution
to carcinogensis. The involvement of miRNAs in breast cancer has been
reiterated and irrefutably proved by many studies. Circulating miRNAs refer to
the cell free miRNAs in the blood or other body fluids, with characteristics
such as remarkable stability, ease of access, minimal invasiveness, possibility
of repeated sampling, and proven roles in cancer development and progression, so
it has been regarded as one of the most potential biomarkers of tumor. This
review focuses on recent-finding of circulating miRNAs as biomarkers in early
diagnostic, prognostic indications and treatment selection, along with an
appraisal of the translational implication of this field. We also addressed the
future and the problems and challenges that need to be overcome to achieve clinical
implementation of circulating miRNAs.