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Yang, G.Y., Taboada, S. and Liao, J. (2009) Inflammatory Bowel Disease: A Model of Chronic Inflammation-Induced Cancer. Methods in Molecular Biology, 511, 193-233.


  • 标题: 慢性炎症与结直肠癌微环境Chronic Inflammation and Colorectal Cancer Microenvironment

    作者: 廉文瑞, 马冬梅, 董培德

    关键字: 慢性炎症, 结直肠癌, 炎症细胞因子, IL-6, TNF-α, TGF-βChronic Inflammation, Colorectal Cancer, Inflammatory Cytokines, IL-6, TNF-α, TGF-β

    期刊名称: 《Advances in Clinical Medicine》, Vol.5 No.4, 2015-12-18

    摘要: 炎症是由病原体的侵袭,物理性或者化学性的损伤引起的十分常见而又重要的基本病理过程,通常可依病程经过分为两大类:急性炎症(acute inflammation)和慢性炎症(chronic inflammation)。急性炎症主要的功能是消除感染损伤的组织,维持体内的生理平衡,慢性炎症却可以引起细胞的恶性转化,进而引起癌症的发生。已有研究结果表明许多的炎症细胞因子在癌症的起始和发展过程中起着很重要的作用,如IL-6,TNF-α和TGF-β等。在本综述中,我们认为这些炎症因子在诱导癌变的过程中发挥了很重要的作用,同时我们分析了这些炎症细胞因子在结直肠炎相关结直肠癌发生过程中的作用。 Inflammation is a very common and important basic pathological process, mainly by the pathogen, physical or chemical damage caused. The course of the disease is divided into two broad categories: acute inflammation and chronic inflammation. The main function of acute inflammation is to eliminate infection of the organization, to maintain the physiological balance in the body. Chronic inflammation can cause cell malignant transformation, resulting in the occurrence of cancer. The existing research results show that many inflammatory cytokines play an important role in the process of development and cancer initiation, such as IL-6, TNF-alpha and TGF-beta. In this review, we argue that these inflammatory factors have played a very important role in the process of in-duced cancer. At the same time, we analyzed its effect of the process of the inflammatory cytokines in proctitis related colorectal cancer.